They had upward slanting eyes, flattening of the back of the head and poorly controlled and fissured tongues.
[downs-syndrome.org.uk]
[…] and thickened tongue, laxness of joint ligaments, pelvic dysplasia, broad hands and feet, stubby fingers, transverse palmar crease, lenticular opacities and heart disease
[icd9data.com]
The lips are large and thick with transverse fissures. The tongue is long, thick, and is much roughened. The nose is small.
[neonatology.org]