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10 Possible Causes for Fissured Tongue, Hypothyroidism, Wide Space Between the First and Second Toe

  • Down Syndrome

    […] and thickened tongue, laxness of joint ligaments, pelvic dysplasia, broad hands and feet, stubby fingers, transverse palmar crease, lenticular opacities and heart disease[icd9data.com] Among the subclinical hypothyroidism group, 25 (73.5%) had transient hypothyroidism and 9 (26.5%) persistent hypothyroidism.[ncbi.nlm.nih.gov] A wide space, often with a deep fissure between the first and second toes, is also common.[dx.doi.org]

  • Familial Congenital Nasolacrimal Duct Obstruction

    Helena Familial OMIM:137400 Geographic and Fissured Tongue OMIM:231080 German Syndrome OMIM:231070 Geroderma Osteodysplasticum; GO OMIM:137440 Gerstmann-Straussler Disease[informatics.jax.org] Thyroid Problems What is hypothyroidism? What causes hypothyroidism? Who gets hypothyroidism? How does hypothyroidism cause disease? What are the common findings?[calvarypediatrics.com] space between first and second toes (sandal toes) clinodactyly of the fifth finger All of these are found in individuals without DS.[medicalhomeportal.org]

  • Weaver Syndrome

    […] epicanthic folds, short nose/broad nasal bridge ( 80%), ear lobe creases ( 70%), macrostomia ( 85%), macroglossia, midline groove in lower lip/deep midline groove in the tongue[karger.com] Macroglossia and hypothyroidism are seldom mentioned in the literature as clinical findings associated with the syndrome.[ncbi.nlm.nih.gov] 1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov]

  • Trisomy 10p

    Epicanthal Folds Mouth And Oral Structures Highly Arched Cleft Palate Bifid Uvula Fissured Tongue Hand And Foot Clubfoot, Flatfoot, Camptodactyly And Clinodactyly Abnormal[neo-genetics.com] 40 to 75 Ophthalmic disorders (congenital cataracts, glaucoma, strabismus) 60 Epilepsy 5 to 10 Gastrointestinal malformations (duodenal atresia, Hirschsprung disease) 5 Hypothyroidism[aafp.org] spaced, inverted nipples, mild pectus excavatum; and a sandal gap between the first and second toes.[jmg.bmj.com]

  • Mild Dysmorphic Features

    Anatomical context of Hypertelorism Common features include postnatal growth retardation, mental retardation , hypotonia , microcephaly , slanted palpebral fissures, ocular[wikigenes.org] The clinical course of the 54 year old man was complicated by hypothyroidism diagnosed at 16 years of age, chronic glomerular nephritis diagnosed at 50 years of age resulting[nature.com] , fourth, and fifth fingers; feet held in eversion, prominent heels; wide space between the first and second toes; proximally placed fifth toes; hypotonia; increased skin[ssmc-tl.com]

  • Baraitser Syndrome

    Mutism Drooling Absent speech Abnormality of the metacarpal bones Absence seizures Joint dislocation Status epilepticus Abnormality of epiphysis morphology Short palpebral fissure[mendelian.co] Other findings included inguinal hernia, hypothyroidism or persistent hyperthyrotropinemia, cryptorchidism, hip dysplasia, growth hormone deficiency, cloudy cornea with congenital[ncbi.nlm.nih.gov] 1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov]

  • Macrocephaly-Developmental Delay Syndrome

    Common minor anomalies include: upward-slanting eyes inner epicanthal folds small upturned nose with saddle bridge a protruding tongue that develops fissures with age Brushfield[medicalhomeportal.org] Short stature, obesity, ‘bulbous’ nasal tip, microretrognathism, brachydactyly, joint hyperlaxity and dislocation and mental retardation Yes Unnamed 27 Juvenile autoimmune hypothyroidism[raredr.com] […] mental retardation include genetic defects, intrauterine infection, placental insufficiency, maternal medication, trauma to the central nervous system, hypoxia, kernicterus, hypothyroidism[aafp.org]

  • Short Stature - Wormian Bones - Dextrocardia Syndrome

    […] hypoplasia  Large fissured lips  Large fissured tongue  Dental abnormalities  Short neck  Atlantoaxial subluxation & instability 68.[slideshare.net] Associations Their associations are various, and include: pyknodysostosis osteogenesis imperfecta rickets kinky hair syndrome cleidocranial dysostosis hypothyroidism hypophosphatasia[radiopaedia.org] Wide spacing between first and second toes ( Matthews and Robin, 2011 ). 3. Skin. a. Short neck with excess nuchal skin. C. Associated findings. 1. Prematurity. 2.[nursekey.com]

  • Tricho-Oculo-Dermo-Vertebral Syndrome

    Additional intraoral findings that may be seen in CD include a high-arched palate and fissured tongue .[pocketdentistry.com] […] congenita Hypodontia-dysplasia of nails syndrome Hypohidrotic ectodermal dysplasia Hypohidrotic ectodermal dysplasia with immunodeficiency Hypohidrotic ectodermal dysplasia-hypothyroidism-ciliary[se-atlas.de] space between the first and second toes, and fusion of carpal and tarsal bones.[findzebra.com]

  • MORM Syndrome

    […] people have these symptoms Myopia Near sightedness Near sighted Close sighted Nearsightedness [ more ] 0000545 80%-99% of people have these symptoms Aplasia/Hypoplasia of the tongue[rarediseases.info.nih.gov] EDNRB OMIM Genetic disorder catalog - Waardenburg syndrome v t e Cell surface receptor deficiencies G protein-coupled receptor (including hormone ) Class A TSHR ( Congenital hypothyroidism[en.wikipedia.org] Features Hypogonadism with Low-Grade Mental Deficiency and Microcephaly hypogonadotropic hypogonadism 23 with or without anosmia Hypohidrotic Ectodermal Dysplasia, with Hypothyroidism[rgd.mcw.edu]

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