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1,631 Possible Causes for Flat Affect, Round Face in Infancy, Significant Clinical Overlap with Sotos Syndrome

  • Weaver Syndrome

    […] and Sotos syndrome Weaver syndrome and Sotos syndrome are often mistaken for one another due to their significant phenotypic overlap and similarities. [8] Clinical features[ipfs.io] Although both sexes are affected, the sex ratio is 2M:1F.[atlasgeneticsoncology.org] […] and Sotos syndrome are often mistaken for one another due to their significant phenotypic overlap and similarities. [8] Clinical features shared by both syndromes include[en.wikipedia.org]

  • Autism

    Her clinical features included hypotonia and feeding difficulties during infancy, coarse face with notably prominent forehead, prominent eyebrows, broad flat nasal bridge[ncbi.nlm.nih.gov] […] and round cheeks, small hands and feet with bilateral brachymetaphalangism, proximal implantation of the thumbs and short toenails, mild mental retardation and autistic behaviour[ncbi.nlm.nih.gov]

    Missing: Significant Clinical Overlap with Sotos Syndrome
  • Endogenous Depression

    Abstract We assessed the 8:00 AM ratio of free cortisol/18-hydroxy-11-deoxycorticosterone (18-OH-DOC) in 56 endogenous depressive inpatients and in 22 normal volunteers. A ratio higher than 40 was associated with a diagnostic sensitivity for endogenous depression of 75%, a specificity of 95.5%, and a diagnostic[…][ncbi.nlm.nih.gov]

    Missing: Round Face in Infancy Significant Clinical Overlap with Sotos Syndrome
  • Stroke

    Post-stroke emotional difficulties include anxiety, panic attacks, flat affect (failure to express emotions), mania, apathy and psychosis.[en.wikipedia.org] […] lip swelling or ulceration • Rhinoscleroma initially affects the nasal mucosa but may spread slowly to the upper lip, producing plaques or nodules with sunken centres. •[slideshare.net] . • In secondary syphilis, moist, flat, papulonodular lesions (condylomata lata) often appear at the mucocutaneous junctions and commissures. • TB or leprosy may cause chronic[slideshare.net]

    Missing: Round Face in Infancy Significant Clinical Overlap with Sotos Syndrome
  • Brain Concussion

    A brain concussion is a still incompletely defined syndrome of traumatic brain injury (TBI) that causes a spectrum of symptoms without evident structural damage to the brain. A headache, cognitive deficits, emotional instability, sleep disturbances, and an overall change in mental state after trauma are highly[…][symptoma.com]

    Missing: Round Face in Infancy Significant Clinical Overlap with Sotos Syndrome
  • Psychosis

    (i.e., flat affect, lack of initiative) rare deterioration of the patients' personality absence of psychosis in the patient's family absence of premorbid schizoid traits[epilepsy.com] Symptoms may include bizarre delusions, prominent hallucinations, incoherence, flat affect, avolition, and anhedonia.[dualdiagnosis.org] Mood disturbances, including euphoria, irritability, and labile or flat affect, have often accompanied psychotic symptoms in these patients.[acnp.org]

    Missing: Round Face in Infancy Significant Clinical Overlap with Sotos Syndrome
  • Schizophrenia

    affect and cognitive slowness.[reddit.com] Symptoms include: “Flat affect” (reduced expression of emotions via facial expression or voice tone) Reduced feelings of pleasure in everyday life Difficulty beginning and[web.archive.org] Negative symptoms are the tendency toward restricted emotions, flat affect (diminished emotional expressiveness), and the inability to start or continue productive activity[drugs.com]

    Missing: Round Face in Infancy Significant Clinical Overlap with Sotos Syndrome
  • XXXXY Syndrome

    face in infancy,(Look very much like a cherub) coarse features in older age, hypertelorism, epicanthal folds, prognathism, gynecomastia (rare), congenital heart defects ([web.archive.org] Affected individuals have distinctive facial features that can include widely spaced eyes ( ocular hypertelorism ), outside corners of the eyes that point upward ( upslanting[ghr.nlm.nih.gov] Other features include severely impaired speech, behavioral problems, short or broad neck, low birth weight, hyperextensible joints, short stature, round face in infancy,[web.archive.org]

    Missing: Significant Clinical Overlap with Sotos Syndrome
  • Catatonic Schizophrenia

    Symptoms such as avolition, impaired social interaction, and flat affect become more frequent over the 25 years of follow-up.[ncbi.nlm.nih.gov] Meanwhile, other symptoms of schizophrenia — such as disorganized speech, flat affect, catatonic, or disorganized behavior — are not present or are less prominent than these[psycom.net] […] clusters; sometimes placed in family Saxifragaceae myotonic dystrophy a severe form of muscular dystrophy marked by generalized weakness and muscular wasting that affects[vocabulary.com]

    Missing: Round Face in Infancy Significant Clinical Overlap with Sotos Syndrome
  • Schizoid Personality Disorder

    In people with SPD, the flat affect varies from failure to show emotion even when it is present, and an actual lack of emotional affectivity in certain situations.[humanologyproject.org] […] distinguishing schizophrenic-like flat affect from depression.[doi.org] Symptoms of schizophrenia include Delusions and paranoia Hallucinations Disordered thinking and speech Flat affect (inability to express emotion) Lack of pleasure in everyday[pchtreatment.com]

    Missing: Round Face in Infancy Significant Clinical Overlap with Sotos Syndrome