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1,916 Possible Causes for Flat Affect, Round Face in Infancy, Small Optic Disc

  • Optic Atrophy-Intellectual Disability Syndrome

    Affected individuals also have distinctive facial features, including widely set eyes (hypertelorism), low-set ears, a small jaw, and a rounded face.[tsbvi.edu] disc small and large excavation; MRI-brain normal - NHLRC2, NR2F1, PLAC1L, POF1B 6 1 Danielle Bosch 00039410 - PubMed: Bosch 2014, Journal: Bosch 2014, PubMed: Bosch 2016[databases.lovd.nl] Most affected individuals have facial features described as coarse.[nfed.org]

  • Autism

    Her clinical features included hypotonia and feeding difficulties during infancy, coarse face with notably prominent forehead, prominent eyebrows, broad flat nasal bridge[ncbi.nlm.nih.gov] […] and round cheeks, small hands and feet with bilateral brachymetaphalangism, proximal implantation of the thumbs and short toenails, mild mental retardation and autistic behaviour[ncbi.nlm.nih.gov]

    Missing: Small Optic Disc
  • Congenital Non-Progressive Ataxia

    Affected individuals also have distinctive facial features, including widely set eyes (hypertelorism), low-set ears, a small jaw, and a rounded face.[tsbvi.edu] Ocular findings in 21 cases published since Gillespie's initial description in 1965 include iris and foveal hypoplasia, nystagmus, and small optic discs with pigmentary retinopathy[ncbi.nlm.nih.gov] For example, affected individuals have exhibited skeletal malformations, such as fusion of certain bones in the spinal column of the neck (cervical vertebrae), flat feet ([rarediseases.org]

  • Endogenous Depression

    Abstract We assessed the 8:00 AM ratio of free cortisol/18-hydroxy-11-deoxycorticosterone (18-OH-DOC) in 56 endogenous depressive inpatients and in 22 normal volunteers. A ratio higher than 40 was associated with a diagnostic sensitivity for endogenous depression of 75%, a specificity of 95.5%, and a diagnostic[…][ncbi.nlm.nih.gov]

    Missing: Round Face in Infancy Small Optic Disc
  • Stroke

    Post-stroke emotional difficulties include anxiety, panic attacks, flat affect (failure to express emotions), mania, apathy and psychosis.[en.wikipedia.org] […] lip swelling or ulceration • Rhinoscleroma initially affects the nasal mucosa but may spread slowly to the upper lip, producing plaques or nodules with sunken centres. •[slideshare.net] . • In secondary syphilis, moist, flat, papulonodular lesions (condylomata lata) often appear at the mucocutaneous junctions and commissures. • TB or leprosy may cause chronic[slideshare.net]

    Missing: Round Face in Infancy Small Optic Disc
  • Brain Concussion

    A brain concussion is a still incompletely defined syndrome of traumatic brain injury (TBI) that causes a spectrum of symptoms without evident structural damage to the brain. A headache, cognitive deficits, emotional instability, sleep disturbances, and an overall change in mental state after trauma are highly[…][symptoma.com]

    Missing: Round Face in Infancy Small Optic Disc
  • Isolated optic nerve hypoplasia

    An overgrowth of retinal pigment epithelium surrounding the small optic disc gives rise to the “double ring sign”.[pediatricneurologybriefs.com] (A) Morning glory optic disc anomaly; (B) hypertelorism and flat nasal bridge – note bilateral iris colobomas; 16.[slideshare.net] ONH is a nonprogressive congenital disc anomaly characterized by a small optic disc with a double-ring sign.[e-tjo.org]

    Missing: Round Face in Infancy
  • Psychosis

    (i.e., flat affect, lack of initiative) rare deterioration of the patients' personality absence of psychosis in the patient's family absence of premorbid schizoid traits[epilepsy.com] Symptoms may include bizarre delusions, prominent hallucinations, incoherence, flat affect, avolition, and anhedonia.[dualdiagnosis.org] Mood disturbances, including euphoria, irritability, and labile or flat affect, have often accompanied psychotic symptoms in these patients.[acnp.org]

    Missing: Round Face in Infancy Small Optic Disc
  • Schizophrenia

    affect and cognitive slowness.[reddit.com] Symptoms include: “Flat affect” (reduced expression of emotions via facial expression or voice tone) Reduced feelings of pleasure in everyday life Difficulty beginning and[web.archive.org] Negative symptoms are the tendency toward restricted emotions, flat affect (diminished emotional expressiveness), and the inability to start or continue productive activity[drugs.com]

    Missing: Round Face in Infancy Small Optic Disc
  • XXXXY Syndrome

    Affected individuals have distinctive facial features that can include widely spaced eyes ( ocular hypertelorism ), outside corners of the eyes that point upward ( upslanting[ghr.nlm.nih.gov] face in infancy,(Look very much like a cherub) coarse features in older age, hypertelorism, epicanthal folds, prognathism, gynecomastia (rare), congenital heart defects ([web.archive.org] They manifest microcephaly with short stature, ocular hypertelorism, flat nasal bridge, and upslanting palpebral fissures.[doi.org]

    Missing: Small Optic Disc

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