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1,290 Possible Causes for Flat Facial Profile, Short Stature in Children, Wide Space Between the First and Second Toe

  • Down Syndrome

    A wide space, often with a deep fissure between the first and second toes, is also common.[dx.doi.org] How Down Syndrome Affects Kids Kids with Down syndrome tend to share certain physical features such as a flat facial profile, an upward slant to the eyes, small ears, and[kidshealth.org] Short stature as the major manifestation of celiac disease in older children. Clin Pediatr 1986; 25:13–6. 12. Rossi TM, Kumar V, Lerner A, et al.[journals.lww.com]

  • Autosomal-Recessive Robinow Syndrome

    Most children with Robinow syndrome experience growth delays after birth, resulting in slight to moderate short stature.[rarediseases.org] Children with autosomal dominant Robinow syndrome have similar but milder features. Spine and rib anomalies are usually not present and short stature is less severe.[rarediseases.org] In addition, short stature, underdevelopment of the forearm bones (radioulnar hypoplasia), and abnormalities of the fingers are more severe.[rarediseases.org]

    Missing: Wide Space Between the First and Second Toe
  • Robinow Syndrome

    ... characterized by craniofacial abnormalities, genital hypoplasia, spinal cord malformations and skeletal dysplasia ... macrocephaly with a flat facial profile, hypertelorism[ibis-birthdefects.org] Most children with Robinow syndrome experience growth delays after birth, resulting in slight to moderate short stature.[rarediseases.org] facial profile, a long philtrum (Fig 1), hyperplastic alveolar ridges, a small upturned nose, a hypoplastic clitoris, short forearms, absence of the upper lacrimal puncta[jamanetwork.com]

    Missing: Wide Space Between the First and Second Toe
  • Atelosteogenesis Type 2

    1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov] Note moderate short stature, flat facial profile (fetal face–like appearance), short forearms, and small hands.[thehealthscience.com] A constitutional short stature in children is not considered as a short stature or dwarfism as the condition happens temporarily and the child will resume normal growth eventually[epainassist.com]

  • Skeletal Dysplasia

    Note moderate short stature, flat facial profile (fetal face–like appearance), short forearms, and small hands.[emedicine.medscape.com] According to epidemiological reports, about 2% of all children in the United States have short stature.[howshealth.com] Skeletal dysplasias are a group of genetic disorders characterized by short stature. They are frequently associated with a range of orthopaedic problems.[muhealth.org]

    Missing: Wide Space Between the First and Second Toe
  • Russell-Silver Syndrome

    1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov] Russell-Silver syndrome (RSS) is characterized by slow growth both in utero and after birth, short stature, and specific facial features.[gemssforschools.org] Ackland FM, Stanhope R, Eyre C, Hamill G, Jones J, Preece MA: Physiological growth hormone secretion in children with short stature and intrauterine growth retardation.[karger.com]

    Missing: Flat Facial Profile
  • Seckel Syndrome

    1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov] One child had classical Seckel syndrome, a sib pair had the features of the syndrome with less severe short stature, and in two children the diagnosis was not confirmed.[ncbi.nlm.nih.gov] The Seckel syndrome or "bird-headed" dwarfism associates a severe short stature, mental deficiency and various malformations with characteristic facial appearance.[ncbi.nlm.nih.gov]

    Missing: Flat Facial Profile
  • SHORT Syndrome

    Kids and teens with Down syndrome tend to share certain physical features such as a flat facial profile, an upward slant to the eyes, small ears, and a protruding tongue.[kidshealth.org] Short Stature in Children Symptoms Short parents tend to have short children.[emedicinehealth.com] How Down Syndrome Affects Kids Kids with Down syndrome tend to share certain physical features such as a flat facial profile, an upward slant to the eyes, small ears, and[kidshealth.org]

    Missing: Wide Space Between the First and Second Toe
  • Crouzon Syndrome

    […] curved inward) facial profile A prominent nasal bridge (a “beaked” nose) Wide-set, bulging eyes Crossed eyes (strabismus) Underdeveloped upper jaw Protruding lower jaw Overcrowded[childrenshospital.org] A five-year-old boy with Crouzon Syndrome, short stature, and delayed bone age was found to have partial growth hormone deficiency.[ncbi.nlm.nih.gov] The clinical features of Crouzon syndrome may include: A skull that appears “too tall” and overly flat from the middle part of the face upward Small cheeks and a concave ([childrenshospital.org]

    Missing: Wide Space Between the First and Second Toe
  • Hypochondroplasia

    Note moderate short stature, flat facial profile (fetal face–like appearance), short forearms, and small hands.[emedicine.medscape.com] In addition to the obvious limb deformities of short stature and bowing, children with achondroplasia typically have frontal bossing (prominent forehead), midface hypoplasia[paleyinstitute.org] PATIENTS: Sixteen children with ACH (aged 0·4-4·3 years), six children with HCH (2·7-6·3 years), 23 children with idiopathic short stature (ISS) (2·2-9·0 years), eight short[ncbi.nlm.nih.gov]

    Missing: Wide Space Between the First and Second Toe