Flat-nasal-bridge: Causes & Reasons

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Possible Causes for flat nasal bridge

Mucopolysaccharidosis

Distinct facial features (including flat face, depressed nasal bridge, and bulging forehead) become more evident in the second year. [en.wikipedia.org]

The most important craniofacial features were brachycephaly, convex/biprotusive profile, flat nasal bridge, closed nasolabial angle, apparent large mouth, and broad lips [hindawi.com]

Physical symptoms generally include coarse or rough facial features (including a flat nasal bridge, thick lips, and enlarged mouth and tongue), short stature with disproportionately [en.wikipedia.org]

Pseudohypoparathyroidism Type 1A

AHO is characterized by short stature, obesity, round face with flat nasal bridge, brachydactyly, subcutaneous ossification and possible / variable developmental delay. [hopkinsmedicine.org]

bridge Depressed bridge of nose Flat bridge of nose Flat nasal bridge Flat, nasal bridge Flattened nasal bridge Low nasal bridge Low nasal root [ more ] 0005280 Ectopic ossification [rarediseases.info.nih.gov]

[…] eruption of teeth Delayed eruption Delayed teeth eruption Delayed tooth eruption Eruption, delayed Late eruption of teeth Late tooth eruption [ more ] 0000684 Depressed nasal [rarediseases.info.nih.gov]

Pallister-Hall Syndrome

Clinical manifestations in infants with Pallister-Hall syndrome included postaxial polydactyly with nail dysplasia, short nose with flat nasal bridge, apparently low-set, [ncbi.nlm.nih.gov]

nasal bridge anteverted nares multiple buccal frenula microglossia cleft lip and palate teeth natal teeth cardiovascular anomalies ventricular septal defect patent ductus [humpath.com]

Symptoms - Pallister-Hall syndrome * Abnormalities of the head, neck, and facial areas including short neck, short midface, flat nasal bridge, small tongue, noticeable underdevelopment [checkorphan.org]

Patau Syndrome

Patau syndrome has an incidence of 1/10.000-20.000, the clinical diagnosis being suggested by the triad cleft lip and palate, microphthalmia/anophthalmia and postaxial polydactyly. Most frequent cytogenetic abnormality is free and homogeneous trisomy 13 (80.0%), rarely being detected trisomy mosaics or Robertsonian[…] [ncbi.nlm.nih.gov]

Mucopolysaccharidosis Type 6

Examples include low and flat nasal bridge, frontal bossing, gingival hypertrophy, macroglossia, and hirsutism [9] [10]. [symptoma.com]

Examples include low and flat nasal bridge, frontal bossing, gingival hypertrophy, macroglossia, and hirsutism. [symptoma.com]

Facial signs include enlarged tongue, prominent eyes, a flat nasal bridge, as well as macrocephaly. [eyewiki.aao.org]

Perinatal Lethal Gaucher Disease

[…] tip, upturned Upturned nasal tip Upturned nose Upturned nostrils [ more ] 0000463 Depressed nasal bridge Depressed bridge of nose Flat bridge of nose Flat nasal bridge Flat [rarediseases.info.nih.gov]

nasal bridge Flattened nasal bridge Low nasal bridge Low nasal root [ more ] 0005280 Ectropion Eyelid turned out 0000656 Fetal akinesia sequence 0001989 Hepatomegaly Enlarged [rarediseases.info.nih.gov]

Pancytopenia Low blood cell count 0001876 Stillbirth Stillborn 0003826 Thrombocytopenia Low platelet count 0001873 30%-79% of people have these symptoms Anteverted nares Nasal [rarediseases.info.nih.gov]

Wolcott-Rallison Syndrome

Summary Epidemiology Fewer than 60 cases have been reported to date. Most patients are from consanguineous families. Prevalence may therefore vary significantly between countries.WRS may be underdiagnosed because of early death before diagnosis. Clinical description Diabetes occurs early, generally before six[…] [orpha.net]

Cleidocranial Dysplasia

Hyperterolism and a broad and flat nasal bridge was noted. On physical examination, a four-finger-width open anterior fontanelle was noted. [ajnr.org]

Cold-Induced Sweating Syndrome Type 1

Infants with Crisponi syndrome have unusual facial features, including a flat nasal bridge, upturned nostrils, philtrum, vaulted palate, micrognathia and low-set ears. [ivami.com]

Infants with Crisponi syndrome have unusual facial features, including a flat nasal bridge, upturned nostrils, a long space between the nose and upper lip (philtrum), a high [ghr.nlm.nih.gov]

[…] or depressed nasal bridge Highly arched palate Long philtrum (groove below nose) Two types of Crisponi syndrome/CISS have been described. [forgottendiseases.org]

Pseudopseudohypoparathyroidism

From Wikidata Jump to navigation Jump to search human disease normocalcemic pseudohypoparathyroidism (disorder) [Ambiguous] pseudopseudohypoparathyroidism (disorder) Normocalcemic pseudohypoparathyroidism Pseudopseudohypoparathyroidism Pseudo-Pseudohypoparathyroidism PPHP AHO-PPHP syndrome Albright hereditary[…] [wikidata.org]

Achondroplasia

bridge Depressed bridge of nose Flat bridge of nose Flat nasal bridge Flat, nasal bridge Flattened nasal bridge Low nasal bridge Low nasal root [2] This gene provides instructions [rarediseases.info.nih.gov]

Symptoms of achondroplasia A normal-length trunk with short arms and legs A large head with a prominent forehead and flat nasal bridge Short and wide hands and feet Short [thesun.co.uk]

nasal bridge Prominent lower jaw Picture from Wolf Wikis North Carolina State University Complications of Achondroplasia The following complications are associated with achondroplasia [healthhype.com]

Mucopolysaccharidosis Type 1 H

Distinct facial features (including flat face, depressed nasal bridge, and bulging forehead) become more evident in the second year. [day2dayparenting.com]

Examination revealed generalized hypotonia, hepatosplenomegaly, and facial dysmorphism along with flat nasal bridge and long philtrum. [pediatricneurosciences.com]

The facial features undergo a marked deterioration, which mainly include a low nasal bridge, flat face, and protruding forehead. [patienthelp.org]

IMAGE Syndrome

Some affected individuals have distinctive facial features, such as a prominent forehead, low-set ears, and a short nose with a flat nasal bridge. [ghr.nlm.nih.gov]

A cranial bone graft may be necessary for correction of the flat nasal bridge line. See the images below. Hypertelorism. The segments have been rotated into position. [emedicine.medscape.com]

Monosomy 1p36 Syndrome

bridge Depressed bridge of nose Flat bridge of nose Flat nasal bridge Flat, nasal bridge Flattened nasal bridge Low nasal bridge Low nasal root [ more ] 0005280 Depressed [rarediseases.info.nih.gov]

nasal bridge 2 4 9 15 17 and midface hypoplasia 6 8 13 were also frequent. [jmg.bmj.com]

Distinct facial features including: Large anterior fontanel ( 100% of patients) Small and pointed chin ( 80%) Flat nasal bridge ( 65%) Clinodactyly and/or short fifth finger [en.wikibooks.org]

Mucopolysaccharidosis Type 1S

Distinct facial features (including flat face, depressed nasal bridge, and bulging forehead) become more evident in the second year. [en.wikipedia.org]

Kniest Dysplasia

Manifestations included neonatal respiratory distress, large head, midface hypoplasia, flat nasal bridge, short nose, micrognathia, cleft palate, short neck, micromelia, and [ncbi.nlm.nih.gov]

The facies are round and the midface is underdeveloped with a flat nasal bridge. Mild psychomotor retardation is sometimes seen. [disorders.eyes.arizona.edu]

Williams-Beuren Syndrome

During the hospitalization, he presented some facial features such as broad forehead, flat nasal bridge, full cheeks, a wide mouth (Figure 1) and a heart murmur. [ijp.tums.pub]

Furthermore, children with WBS have characteristic craniofacial features such as periorbital fullness, medial eyebrow flare, stellate iris, flat nasal bridge, strabismus, [ijmpo.org]

In Williams-Beuren syndrome (WBS), facial features include full cheeks, flat nasal bridge, long philtrum, periorbital fullness, wide mouth, full lips and anteverted ears. [scielo.br]

Partial Monosomy 18q

[…] feet wide flat nasal bridge thin upper lip also had hard time nursing as a baby due to a high arched palate this is a short list of his many issues i know this is a long [circleofmoms.com]

nasal bridge Anteverted nares Hypertelorism (widely spaced eyes) Epicanthal folds (skin fold over inner corner of eyes) Whole Body Features Associated with 9p Deletions: [9pminus.org]

bridge. [labmed.hallym.ac.kr]

Spondyloepimetaphyseal Dysplasia Type SPONASTRIME

] 0002750 Depressed nasal bridge Depressed bridge of nose Flat bridge of nose Flat nasal bridge Flat, nasal bridge Flattened nasal bridge Low nasal bridge Low nasal root [ [rarediseases.info.nih.gov]

[…] tip, upturned Upturned nasal tip Upturned nose Upturned nostrils [ more ] 0000463 Delayed skeletal maturation Delayed bone maturation Delayed skeletal development [ more [rarediseases.info.nih.gov]

[…] of the metacarpal bones Abnormality of the long bone of hand 0001163 Abnormality of the metaphysis Abnormality of the wide portion of a long bone 0000944 Anteverted nares Nasal [rarediseases.info.nih.gov]

Mohr Syndrome

Distinctive facial features often associated with oral-facial-digital syndrome include a split in the lip (a cleft lip ); a wide nose with a broad, flat nasal bridge ; and [ghr.nlm.nih.gov]

Costello Syndrome

Characteristic facial features include: down-slanting palpebral fissures, short nose with flat nasal bridge, tall broad forehead, widow's peak in the anterior hairline, and [orpha.net]

nasal bridge with epicanthic folds Square mandible with a pointed chin Prominent tongue Full cheeks and lips with a wide mouth Characteristic hands Hypermobile with ulnar [dermnetnz.org]

[…] patient's life can include: Characteristic facial features Macrocephaly with a high forehead Bitemporal narrowing Large-cupped and posteriorly rotated ears with folded earlobes Flat [dermnetnz.org]

Congenital Non-Goitrous Hypothyroidism Type 4

Abstract Thyroid hormone status was assessed in 132 children with congenital heart defects undergoing cardiac surgery (median age 3.1 y; range 2 d to 16.2 y). Plasma TSH, thyroxine (T4), free thyroxine (fT4), triiodothyronine (T3), reverse triiodothyronine (rT3), thyroglobulin (Tg), and urinary iodine excretion were[…] [ncbi.nlm.nih.gov]

Atelosteogenesis

The patient had multiple craniofacial abnormalities at birth, including ocular hypertelorism, a flat nasal bridge, micrognathia and a cleft palate. [ncbi.nlm.nih.gov]

Marshall-Smith Syndrome

[…] cavity 0000452 Death in childhood 0003819 Decreased body weight Decreased weight Low body weight Low weight Weight less than 3rd percentile [ more ] 0004325 Depressed nasal [rarediseases.info.nih.gov]

[…] middle phalanges of the hand Bullet-shaped middle finger bones 0009845 Cerebral atrophy Degeneration of cerebrum 0002059 Choanal stenosis Narrowing of the rear opening of the nasal [rarediseases.info.nih.gov]

Sanjad-Sakati Syndrome

nasal bridge Liver disease in the neonatal stages Neutropenia or low levels of neutrophils (a type of white blood cells) Susceptibility to repeated infections Abnormal teeth [dovemed.com]

[…] bones The signs and symptoms specific to KCS type 1 may include: Abnormally small head Facial abnormalities such as: Up-slanting eyes Extremely thin lips Under-developed jaw Flat [dovemed.com]

Stickler Syndrome Type 2

bridge, and small upturned nasal tip. [encyclopedia.com]

Individuals with Marshall syndrome manifest ocular hypertelorism, hypoplasia of the maxilla and nasal bones, flat nasal bridge and small upturned nasal tip ... [ibis-birthdefects.org]

Glycogen Storage Disease Type 3

OBJECTIVES: Glycogen storage disease type 3 (GSD-III) is a rare inherited metabolic disorder caused by glycogen debranching enzyme deficiency. Various pathogenic mutations of the AGL gene lead to abnormal accumulation of glycogen in liver, skeletal, and cardiac muscles. Here, we report distinct clinical and genetic[…] [ncbi.nlm.nih.gov]

Multiple Congenital Anomalies - Hypotonia - Seizures Type 3

[…] over the frontal and temporal regions, hypertelorism, a broad nasal bridge, a small anteverted nose, a high arched palate, microretrognathia, a cupid-bow shaped upper lip [epilepsydiagnosis.org]

PALLISTER KILLIAN SYNDROME (TETRASOMY 12p) This chromosomal abnormality results in dysmorphic features that include a coarsened flat facies, high forehead, reduced scalp hair [epilepsydiagnosis.org]

Mucopolysaccharidosis Type 1 H/S

Distinct facial features (including flat face, depressed nasal bridge, and bulging forehead) become more evident in the second year. [smartspeechtherapy.com]

Jacobsen Syndrome

nasal bridge (early aspect) Prominent nasal bridge (late aspect) Short nose Anteverted nares Prominent columella Broad nasal bridge Ears Small ears Low set ears Posteriorly [ncbi.nlm.nih.gov]

[…] thrive Faltering weight Weight faltering [ more ] 0001508 Flat occiput 0005469 Flexion contracture Flexed joint that cannot be straightened 0001371 Generalized hypotonia [rarediseases.info.nih.gov]