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2,876 Possible Causes for Flattening of the Talar Dome, Joint Stiffness, Mutation in the PHEX Gene

  • X-Linked Hypophosphatemia

    To date, 131 mutations in the PHEX gene have been reported.[ncbi.nlm.nih.gov] […] shortening of the talar neck and flattening of the talar dome.[ncbi.nlm.nih.gov] )), bone pain (42/71 (59%)), joint stiffness (30/71 (42%)) and short stature (57/71(80%)).[bone-abstracts.org]

  • Familial Hypophosphatemia

    X-linked dominant hypophosphatemic rickets, due to mutations in the PHEX gene, is the most common inherited form of the disorder.[genedx.com] Since, the gene mutation occurs on the X chromosome, it is called an X-linked disorder Familial Hypophosphatemia is caused by a mutation in the PHEX gene, leading to defective[dovemed.com] Mutated in X-Linked Dominant Hypophosphatemic Rickets Genome Research 7 573-585 (1997) Dixon, PH et al., Mutational Analysis of PHEX Gene in X-linked Hypophosphatemia J Clin[genedx.com]

    Missing: Flattening of the Talar Dome
  • Ankle Arthritis

    Relative radiographic contraindications to performing an ankle distraction include flattening of the talar dome, presence of greater than five degrees of valgus or varus deformity[faoj.org] Signs Of Ankle Joint Arthritis Ankle Joint Stiffness Joint movement like dorsiflexion and plantar flexion is restricted because of joint stiffness.[epainassist.com] Also associated with stiffness after getting out of a car or after sitting in a chair to get up and walk. With progression a chronic ache in the ankle joint.[southfloridasportsmedicine.com]

    Missing: Mutation in the PHEX Gene
  • Arthritis

    Arthritis is the inflammation of one or more joints. The main symptoms are joint pain, swelling and stiffness.[symptoma.com] "Arthritis" describes many different diseases that cause tenderness, pain, swelling, and joint stiffness.[spine-health.com] Symptoms may include: Pain or aching in more than one joint Stiffness in more than one joint. Tender, swollen joints. Weight loss. Fatigue, or tiredness. Fever.[web.archive.org]

    Missing: Flattening of the Talar Dome Mutation in the PHEX Gene
  • Osteoarthritis

    The absolute reduction in finger joint stiffness for the exercise group, compared with the control group, was 7% (3% to 10%).[ncbi.nlm.nih.gov] Follow‐up: mean 3 months Mean finger joint stiffness in control groups was 4.5 points g Mean finger joint stiffness in intervention groups was 0.7 points lower (0.3 to 1.0[doi.org] […] no morning joint-related stiffness or morning stiffness that lasts no longer than 30 minutes.[patient.info]

    Missing: Flattening of the Talar Dome Mutation in the PHEX Gene
  • Hereditary Hypophosphatemic Rickets with Hypercalciuria

    This process is due to mutations in the FGF23 and PHEX gene.[ivami.com] Rheumatology Although disease severity is variable, adults with HR may suffer from osteoarticular symptoms, such as pain and joint stiffness, leading to disability of physical[ec.bioscientifica.com] The most common form is the X-linked dominant hypophosphatemic rickets caused by inactivating mutations in the PHEX gene.[medigraphic.com]

    Missing: Flattening of the Talar Dome
  • Gouty Arthritis

    When gout is more severe or longstanding, multiple joints may be affected at the same time. This causes pain and joint stiffness in multiple joints.[medicinenet.com] Fever Stiffness in the joint Itchy skin – as the gout attack subsides, skin around the joint may itch and peel away Small lumps ( tophi ) appear around the elbows, hands,[pafootdoctors.com] It causes swollen, red, hot and stiff joints. Gout happens when uric acid builds up in your body. Uric acid comes from the breakdown of substances called purines.[fpnotebook.com]

    Missing: Flattening of the Talar Dome Mutation in the PHEX Gene
  • Vitamin D Deficiency

    […] in the PHEX gene.[ncbi.nlm.nih.gov] Feeling tired all of the time, stiff joints and heaviness or pain in the legs could point to a deficiency.[poughkeepsiejournal.com] So much pain and stiffness and I was miserable. Remembered to take vitamin d three days ago and suddenly the bone pain has eased. My hands work again![healthyway.com]

    Missing: Flattening of the Talar Dome
  • Polyarthritis

    OBJECTIVES: Patients with rheumatoid arthritis (RA), psoriatic arthritis (PsA) or unspecified polyarthritis (UA) deal with several symptoms such as joint stiffness, pain,[ncbi.nlm.nih.gov] Find Rheumatologists near you Although I don't know all of the information about your case, I therefore gather that you have a fairly significant degree of joint stiffness[zocdoc.com] He added, "many a time, people experience morning stiffness and spontaneous joint swelling.[zeenews.india.com]

    Missing: Flattening of the Talar Dome Mutation in the PHEX Gene
  • Psoriasis

    There may also be a loss of range of motion of the involved joints as well as joint stiffness.[onhealth.com] Psoriatic arthritis produces swelling and stiffness in the joints or stiffness in the lower back and should be managed by a rheumatologist who works closely with your dermatologist[britishskinfoundation.org.uk] An estimated 30% of people with psoriasis will also develop psoriatic arthritis , a disease which causes joint pain, stiffness, and swelling.[health.com]

    Missing: Flattening of the Talar Dome Mutation in the PHEX Gene

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