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175 Possible Causes for Floppy Muscle, Tongue Weakness, Vacuolization

  • Oculo-Pharyngo-Distal Myopathy

    Muscular dystrophy changes with rimmed vacuoles were the main histopathological changes.[ncbi.nlm.nih.gov] […] muscles Bulbar Dysphagia: Oropharyngeal Dysarthria: Hoarse & Nasal voice Tongue weakness Limbs Legs Arms Distal: Anterior tibial; Finger extensors Onset: 5 years after disease[neuromuscular.wustl.edu] Weakness 497 Case 79 A Boy Born Floppy with Severe Weakness and Later Contractures 503 Case 80 A Woman with Longstanding Weakness and Foot Deformities 510 Case 81 A Woman[books.google.com]

  • Limb-Girdle Muscular Dystrophy

    […] pathology Vacuoles/ultrastructure Substances Chromatin LMNA protein, human Lamin Type A MyoD Protein MyoD1 myogenic differentiation protein PAX7 Transcription Factor PAX7[ncbi.nlm.nih.gov] Involvement of the heart, respiratory muscles or tongue. (Facial weakness is not usual.)[patient.info] […] no symptoms Bethlem myopathy Floppy muscles in infancy 2/3 of patents are wheelchair bound Proximal muscle weakness by age 50 Contractures * Includes alpha, beta, gamma and[encyclopedia.com]

  • Pernicious Anemia

    The histopathology of WKS is incomplete loss of neurons, damage of axons and myelin which casuses loosening or vacuolization of the neuropil, and punctate hemorrhages.The[neuropathology-web.org] Weak muscles The symptoms of megaloblastic anemia may resemble other blood conditions or medical problems.[stanfordchildrens.org] The swollen individual myelinated fibers give a vacuolated sieve-like appearance to stained cross-sections of the spinal cord.[ispub.com]

  • Muscular Dystrophy

    Familial distal myopathy with rimmed vacuole and lamellar (myeloid) body formation . J Neurol Sci, 1981; 51: 141–155.[link.springer.com] Symptoms include difficulty swallowing (dysphagia), tongue weakness, weakness in the proximal muscles, difficulty looking up or double-vision (diplopia), and closing or drooping[medbroadcast.com] Symptoms include: Myotonia (prolonged muscle spasm) in the fingers and facial muscles A floppy-footed, high-stepping gait (walk or run) Cataracts Heart abnormalities Endocrine[ohsu.edu]

  • Oculopharyngeal Muscular Dystrophy

    In contrast, patients with distal myopathy with rimmed vacuoles revealed many rimmed vacuoles, on average in 20% of the fibers, and their oculopharyngeal muscles were spared[ncbi.nlm.nih.gov] Symptoms may include: difficulty swallowing (dysphagia) tongue weakness and atrophy weakness in the proximal muscles drooping eyelids (ptosis) difficulty gazing upwards and[muscle.ca] In young babies, the muscle weakness may be noticed as 'floppiness' of the baby.[patient.info]

  • Distal Myopathy Type 3

    Tubulofilamentous inclusion, myeloid bodies, and autophagic vacuoles in the area corresponding to rimmed vacuoles ( d ; bar 1 μm).[karger.com] (ie, tongue and pharyngeal weakness) is manifested by symptoms of dysarthria and dysphagia.[sites.google.com] Muscle biopsy will demonstrate the dystrophic myopathy.[explainmedicine.com]

  • Progressive Bulbar Palsy

    IVIg) Myopathies, including inclusion body myositis, which is characterized by wasting and weakness of deep finger flexors and the quadriceps femoris with typical rimmed vacuoles[emedicine.medscape.com] Clinical manifestations include dysarthria, dysphagia, facial weakness, tongue weakness, and fasciculations of the tongue and facial muscles.[icd9data.com] In some people, muscle tone decreases, making the limbs seem loose and floppy. Controlling facial expressions may become difficult.[merck.com]

  • Sarcotubular Myopathy

    The vacuoles are similar to those described in sarcotubular myopathy. TRIM32 sequencing revealed the common c.1459G A mutation at homozygosity.[ncbi.nlm.nih.gov] Patients may have prominent tongue hypertrophy and severe weakness and wasting of upper arms, neck flexors, and axial muscles; these features can help in distinguishing this[emedicine.medscape.com] In most instances, the affected infant shows less than the usual power of muscle contraction, hypotonia (floppiness and lack of resistance to passive movement of the limbs[healthcentral.com]

  • Hypocupremia

    (a) Early myeloid and erythroid precursors with cytoplasmic vacuoles (Wright, 1000). (b) Myeloid blast and vacuolated early erythroid precursors (Wright, 1000).[ncbi.nlm.nih.gov] […] convulsions Peripheral sensory neuropathy, ataxia, perioral numbness Folate Megaloblastic anemia, glossitis, hair loss, cognitive defects, pallor, persistent fatigue, tender tongue[emedicinehealth.com] […] is a hereditary condition caused by a defective gene involved with the metabolism of copper in the body. [7] Menkes disease involves a wide variety of symptoms including floppy[en.wikipedia.org]

  • Autosomal Recessive Limb-Girdle Muscular Dystrophy

    Histopathology of skeletal muscles biopsies showed typical dystrophic changes with many rimmed vacuoles.[ncbi.nlm.nih.gov] Involvement of the heart, respiratory muscles or tongue. (Facial weakness is not usual.)[patient.info] […] no symptoms Bethlem myopathy Floppy muscles in infancy 2/3 of patents are wheelchair bound Proximal muscle weakness by age 50 Contractures * Includes alpha, beta, gamma and[encyclopedia.com]

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