Foam Cell: Causes & Reasons

Possible Causes for Foam Cell

As the foam cells penetrate the artery walls, they further injure the artery. [encyclopedia.com]

Foam cells accumulate to form fatty streaks (early atherosclerotic lesions). [amboss.com]

Fatty streak — The first stage in atherosclerosis; consists of lipid, macrophages, and immune cells. Foam cell — A macrophage that has ingested lipid. [encyclopedia.com]

Tendon Sheath Giant Cell Tumor

fibroblast-like cells, multinucleated giant cells, foam cells Back to top [pathologyoutlines.com]

It is characterized by the presence of mononuclear cells, multinucleated osteoclast-like giant cells, hemosiderin-laden macrophages, foam cells, and an inflammatory infiltrate [icd9data.com]

The histological picture is characteristic and shows osteoclast-like giant cells, histiocytic cells, foam cells and focal haemosiderosis. [link.springer.com]

Niemann-Pick Disease Type B

[…] and histiocytes in several organs as lung, liver, spleen, kidney. microvacuolated hepatocytes (hepatic microsteatosis) large vacuolated foam cells (’NP cells’) on bone marrow [humpath.com]

Although pseudo-Gaucher cells and sea blue histiocytes can be found in bone marrow that is rapidly turning over, the combination of both numerous foam cells and sea blue histiocytes [imagebank.hematology.org]

Bone marrow biopsy showed plenty of foam cells and sphingomyelinase level was low, thus conforming our diagnosis. [ncbi.nlm.nih.gov]

Xanthoma Disseminatum

It is thought that lipoproteins permeate the vessel walls and then develop foam cells. [ncbi.nlm.nih.gov]

[…] lymphocytes, neutrophils, plasma cells,and occasional foam cells, the features suggestive of XD [Figure - 2]a-c. [ijdvl.com]

Microscopically, these lesions contain an abundant amount of foam cells. Basically, the foam cells are macrophages. [xanthelasmatreatment.com]

Pigmented Villonodular Synovitis

cells that resemble lining cells; giant cells appear to have phagocytic role; findings include deposition of iron, foam cells, or giant cells; Treatment: arthroscopic synovectomy [wheelessonline.com]

Biopsy of joint synovium found villous nodules, the invasion of foam cells, and hemosiderin deposition. [ncbi.nlm.nih.gov]

Multinucleated giant cells. Hemosiderin-laden macrophages. Foam cells. DDx - general for the site: [11] Synovial chondromatosis. Gout. Pseudogout. Storage disorders. [librepathology.org]

Niemann-Pick Disease

Similar foam cells in hypercholesterolemia and Tangier disease Also disorders with massive cell destruction that overloads body's capacity to digest lipids ( thalassemia, [pathologyoutlines.com]

Bone marrow biopsy showed plenty of foam cells and sphingomyelinase level was low, thus conforming our diagnosis. [ncbi.nlm.nih.gov]

Foam cells were present in the bone marrow aspirate too, that contained also sea-blue histiocytes. [ncbi.nlm.nih.gov]

Juvenile Xanthogranuloma

[…] xanthogranuloma : storiform array of cells and Touton type giant cells Xanthoma : associated with hyperlipidemia, uniform collection of foam cells and variable Touton giant [pathologyoutlines.com]

Numerous foam cells are seen throughout the dermis (original magnification × 4) (A). Giant cells and numerous foam cells are seen. [medicaljournals.se]

Papular xanthomas contain foam cells and Touton giant cells, but lack the mixed inflammatory infiltrate found in juvenile xanthogranulomas. [path.upmc.edu]

Aortic Arteriosclerosis

Pathogenesis Atheromatous plaques begin as fatty streaks composed of lipid-laden macrophages (foam cells). [radiopaedia.org]

(WBCs) (foam cell) and proliferation of intimal smooth muscle cell creating a fibrofatty plaque. [icd.codes]

Classification of lesions[edit] Type I: Isolated macrophage foam cells[6][12] Type II: Multiple foam cell layers[6][12] Type III: Preatheroma, intermediate lesion[6][12] Type [en.wikipedia.org]

Tangier Disease

Histologically, "foam cells" were recognized in the lymphoid tissue of the pharynx and rectal mucosa. [ncbi.nlm.nih.gov]

Histopathologically accumulation of foam cells which showed lipid vacuoles and myeline figures on electron microscopy were observed. [ncbi.nlm.nih.gov]

Impaired cholesterol efflux from macrophages leads to the presence of foam cells throughout the body, which may explain the increased risk of coronary heart disease in some [ncbi.nlm.nih.gov]

Lecithin Acyltransferase Deficiency

The histologic findings were those of membranous glomerulonephritis with very few intracapillar foam cells. [ncbi.nlm.nih.gov]

Interaction of normal LpA-I or LpA-I/A-II with macrophage foam cells induced a mass reduction in cholesterol from these cells and the cholesterol reducing capacity of LpA-I [ncbi.nlm.nih.gov]

Renal biopsy revealed foam cells and an increased mesangial matrix in the glomeruli. [ncbi.nlm.nih.gov]

Cholesterol Ester Storage Disease

These organs appear to be infiltrated by macrophages filled with cholesteryl esters and triglycerides ( foam cell infiltration ). [bredagenetics.com]

[…] acid lipase activity resulting in widespread accumulation of cholesterol esters and triglycerides in viscera with xanthomatosis, adrenal calcification, hepatosplenomegaly, foam [medical-dictionary.thefreedictionary.com]

cells of the hepatic portal triads, duodenum, and ovaries. [ncbi.nlm.nih.gov]

Necrobiotic Xanthogranuloma

Not only subcutaneous involvement, but also, evident zones of degenerated collagen, foam cells, and cholesterol clefts were missing. [ncbi.nlm.nih.gov]

cells in the reticular dermis ; Superficial and deep perivascular lymphoplasmacytic infiltrate ; Presence of foam cells, multinucleated giant cells (Touton and foreign body [histopathology-india.net]

XD—Diffuse epithelioid histiocytes, foam cells, and siderosis ■ IHC repertoire: NXG—CD-68(+), S-100(-), CD-1(-) XD—CD-68(+), S-100(-),CD-1(-) ■ Staging: NXG—None XD—None [mussenhealth.us]

Alport Syndrome

Foam cells were seen in only one case. [ncbi.nlm.nih.gov]

Renal biopsy was performed and light microscopic findings showed segmental mesangial cell proliferation and numerous interstitial foam cells without significant findings by [ncbi.nlm.nih.gov]

Light microscopy of renal biopsy specimens revealed segmental glomerular sclerosis and interstitial foam cells only in patients with the GBM changes. [ncbi.nlm.nih.gov]

Bone Fibroma

The authors describe a fibroblastic cell type as the basis of the neoplasia which transforms itself into a foam cell loaded with lipids. [link.springer.com]

Foam cells and hemosiderin deposition are present. Mitoses are seen but cytologic atypia is absent. [librepathology.org]

[…] be surrounded by a well defined thin rim of reactive bone; - no periosteal reaction is seen unless there has been a frx; - Histology: - look for whorled fibrous tissue, foam [wheelessonline.com]

Hyperlipoproteinemia Type 5

H and E, ×40 Xanthomas are plaques or nodules consisting of accumulation of lipid-rich macrophages known as foam cells. [1],[2] They do not represent a disease but rather [ijdvl.com]

H and E, ×40 Click here to view Xanthomas are plaques or nodules consisting of accumulation of lipid-rich macrophages known as foam cells. [1], [2] They do not represent a [ijdvl.com]

As a result of massive cholesterol deposition, these macrophages become foam cells, which may be the progenitors of cholesterol-laden cells in the atherosclerotic lesion. [ommbid.mhmedical.com]

Lipoprotein Glomerulopathy

Moreover, the macrophage impairment in LPG may provide another mechanism for lipoprotein thrombi in which massive lipoproteins accumulate in the glomerulus without foam cells [ncbi.nlm.nih.gov]

These cells are known to playa central role in the formation of a fatty streak consist ing of lipid-laden foam cells. [books.google.de]

McKenzie IFC, Kinkaid-Smith P (1969) Foam cells in the renal glomerulus. J Pathol 97: 151–154 Google Scholar 5. [link.springer.com]

Wolman Disease

These organs appear to be infiltrated by macrophages filled with cholesteryl esters and triglycerides ( foam cell infiltration ). [bredagenetics.com]

cell infiltration bone marrow foam cells vacuolated blood lymphocytes liver, adrenal, spleen, lymph nodes, bone marrow, small intestine, lungs and thymus, skin, retina, central [humpath.com]

cells in the bone marrow and other tissues. [whonamedit.com]

Galactosialidosis

All patients have clinical manifestations typical of a lysosomal disorder, such as coarse facies, cherry red spots, vertebral changes, foam cells in the bone marrow, and vacuolated [uniprot.org]

All patients with galactosialidosis have foam cells in the marrow and vacuolated lymphocytes in peripheral blood. Vacuoles may also be seen in Kupffer cells. [taylorfrancis.com]

All patients have clinical manifestations typical of a lysosomal storage disease, including coarse facies, cherry-red spots, vertebral changes, foam cells in the bone marrow [ommbid.mhmedical.com]

Hyperlipoproteinemia Type 1

E: Palmar crease xanthomas are filled with foam cells and appear as yellowish deposits within palmar creases. [cmaj.ca]

Tuberous xanthomata reveal foam cells and cholesterol clefts. [ijpd.in]

D: Tuberous xanthomas, filled with foam cells, appear as reddish or orange, often shiny nodules, up to 3 cm in diameter. They are usually moveable and nontender. [cmaj.ca]

Sea-blue histiocytosis

Image (1) shows clusters of foam cells. [pathopedia-india.com]

Sen Gupta PC et al (1960) Observations on the foam cell in thalassemia. Blood 16:1039–1044 PubMed 13. [springermedizin.de]

Histological features of NP-C include numerous reports of foamy cells and/or SBH in the bone marrow aspirates. [9] Mere presence of the foam cells and SBH has lesser sensitivity [annalsofian.org]

Hyperlipoproteinemia Type 3

Tuberous xanthomata reveal foam cells and cholesterol clefts. [ijpd.in]

As a result of massive cholesterol deposition, these macrophages become foam cells, which may be the progenitors of cholesterol-laden cells in the atherosclerotic lesion. [ommbid.mhmedical.com]

The remnant particles are susceptible to uptake by macrophages in peripheral tissues, which may become cholesterol-laden foam cells and lead to atherosclerosis. [cancertherapyadvisor.com]

Hyperlipoproteinemia

H and E, ×40 Xanthomas are plaques or nodules consisting of accumulation of lipid-rich macrophages known as foam cells. [1],[2] They do not represent a disease but rather [ijdvl.com]

Histopathologic findings showed many Touton giant cells and numerous foam cells in the dermis. [ncbi.nlm.nih.gov]

Tuberous xanthomata reveal foam cells and cholesterol clefts. [ijpd.in]

Hypoalphalipoproteinemia

cells, tonsillar enlargement, an orange or yellow-gray color of the pharyngeal and rectal mucosa, hepatosplenomegaly, lymph node enlargement, corneal opacity, and peripheral [medical-dictionary.thefreedictionary.com]

Histological examination of skin lesions reveals numerous foam cells. Diagnosis is confirmed by genetic testing. [checkorphan.org]

This is because HDL has the ability to promote the efflux of cholesterol from atherogenic foam cells in the arterial wall and to mediate reverse cholesterol transport from [clinicaladvisor.com]

Chitotriosidase Deficiency

The formation of lipid-laden foam cells from macrophages represents a landmark for atherosclerosis.4,5 The development of foam cells is mainly attributable to overloading [ahajournals.org]

Verruciform Xanthoma of the Skin

Ultraestructural observations on foams cells and the source of their lipid in verruciform xanthoma. J Am Acad Dermatol. 1991;24:760-4. 29. [revistasocolderma.org]

Xanthoma

In our case, the foam cells showed strong CD68 immunoreactivity. CD68 is a cell marker confirming the possible role of macrophages in the formation of foam cells [12]. [hindawi.com]

The KP1 and Mac 387 immunostain showed focal weak staining in foam cells. [insights.ovid.com]

Foam cells can also develop as a result of in situ lipid synthesis by the macrophage. [accessmedicine.mhmedical.com]

Xanthogranulomatous Cholecystitis

Microscopically, there are varying amounts of inflammation, xanthoma-like foam cells, and scarring. [pubmed.ncbi.nlm.nih.gov]

Cephalin Lipidosis

Observations on foam cells in thalassemia. Blood. 1960; 16: 1039 PubMed Google Scholar Dooren L.J. Von Gelderen H.H. Vink C.L.J. Exudative enteropathy. [amjmed.com]

Synovial Neoplasm

Foam cells and iron deposits appear to be secondary changes and are usually seen in the periphery of the expanding nodules. [scienceopen.com]

or both, beneath the synovial or tenosynovial lining cells, and by collagen production. [scienceopen.com]

[…] nodular, multiple nodular, and diffuse lesions suggested that they have a common histogenesis that is characterized by proliferation of fibroblastic or histiocytic mesenchymal cells [scienceopen.com]

Meningeal Sarcomatosis

JAMA Neurology 2022 American Medical Association. All Rights Reserved Sign In Access through your institution Sign In March 1983 Arch Neurol. 1983;40(3):179-182. doi:10.1001/archneur.1983.04050030073016 Full Text • We report the clinical course and the pathological findings in a 28-year-old woman in whom a chronic,[…] [jamanetwork.com]