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29 Possible Causes for Focal Keratoderma of Soles, Hypothyroidism

  • Growth Hormone Deficiency

    Palmoplantar keratoderma (PPK) is a diverse group of disorders, characterized by thickening of the palms and soles, which are subdivided into focal or diffuse; it can be acquired[] A positive thyroid autoantibody titer confirmed the diagnosis of chronic lymphocytic thyroiditis with hypothyroidism.[] They may be associated with endocrine disorders, including hypothyroidism, diabetes mellitus, hyperinsulinemia and growth hormone (GH) deficiency.[]

  • Palmoplantar Keratosis

    […] x-linked dominant condition that begins in early childhood with thick focal keratoderma over the soles and, to a lesser extent, the palms.[] .: Palmoplantar keratoderma associated with hypothyroidism. Br J Dermatol 1998; 139: 741–2 PubMed CrossRef Google Scholar 43.[] Cutaneous manifestations of hypothyroidism amongst gynecological consultations. Int J Health Sci. 2010;4:168-177. Flohr C.[]

  • Pityriasis Rubra Pilaris

    There was a waxy orange keratoderma affecting the palms and soles with associated painful fissuring ( figure 3 ).[] The relation to hypothyroidism is partially established.[] Key words: Hypothyroidism; Pityriasis rubra pilaris; Therapeutics INTRODUCTION Pityriasis Rubra Pilaris is a chronic dermatosis of unknown etiology.[]

  • Evan's Syndrome

    Clinical description Tylosis (hyperkeratosis palmaris et plantaris) is a focal, non-epidermolytic form of keratoderma characterised by areas of yellowish thickened plaques[] Thyroid disease in progressive systemic sclerosis: increased frequency of glandular fibrosis and hypothyroidism. Ann. Intern. Med. 95 :431, 1981.[] There were no signs or symptoms of overt hypothyroidism.[]

  • Chest Wall Disorder

    Necrolytic migratory erythema due to glucagonoma Tylosis Tylosis is an autosomal dominant form of focal, non-frictional and nonepidermolytic, palmoplantar keratoderma.[] Normal thyroid hormone levels rule out hypothyroidism as a cause of hyperprolactinemia.[] With hypothyroidism or an under active thyroid, the heart rate will be very slow, and the function of the heart will be impaired enough so that pain may occur during exertion[]

  • Papillon Lefevre Disease

    Focal keratodermas mainly affect pressure areas. Punctate-type keratodermas result in tiny bumps on the palms and soles.[] PPK as a feature of systemic disease – Hypothyroidism , myxedema, diabetes mellitus, and chronic lymphedema .[] Palmar-plantar hyperkeratosis Group of disorders known as palmar plantar keratodermas (PPK) are characterized by diffuse or localized hyperkeratosis of the palms and soles[]

  • Erythema Palmaris Hereditarium

    […] involving the whole of the palms and soles. [1] :506–8 [2] :213 Focal Focal palmoplantar keratoderma, a type of palmoplantar keratoderma in which large, compact masses of[] Agenesis of premolar Acrokeratosis Acantholysis Prolactinoma Renal angiomyolipoma Pancreatic islet cell adenoma Pancreatic endocrine tumor Hypertension Diabetes mellitus Hypothyroidism[] […] syndrome Hypodontia-dysplasia of nails syndrome Hypohidrotic ectodermal dysplasia Hypohidrotic ectodermal dysplasia with immunodeficiency Hypohidrotic ectodermal dysplasia-hypothyroidism-ciliary[]

  • Lamellar Ichthyosis

    […] and soles ( Lucker et al., 1994 ).For a discussion of phenotypic and genetic heterogeneity of palmoplantar keratoderma, see epidermolytic PPK ( OMIM ).[] We present the first case of an infant, born to consanguineous parents, with congenital lamellar ichthyosis, congenital lymphatic malformation, congenital hypothyroidism,[] No evidence of congenital hypothyroidism or sensitivity to gluten usually associated to LI Tunisian phenotype was noted.[]

  • Epidermolysis Bullosa

    ., belt line) Generalized Generalized Generalized Grouped (herpetiform) No No Sometimes Yes Mucosal Rare Occasionally Occasionally Often Hyperkeratosis of palms & soles (keratoderma[] The endocrinology department ruled out associated hypothyroidism and suprarenal insufficiency.[] Genes Project, Genetic and Rare Diseases Organization v t e Cell surface receptor deficiencies G protein-coupled receptor (including hormone ) Class A TSHR ( Congenital hypothyroidism[]

  • Jadassohn-Lewandowsky Syndrome

    Fig 2: Showing focal keratoderma on soles. Fig 3: Showing pachyonychia in hands and feet. Fig 4: Showing leukoplakia on tongue and angular cheilitis of mouth.[] Nail dysplasia Hypoplasia of the thymus Severe combined immunodeficiency Thyroiditis Ventricular septal defect Autosomal dominant inheritance Hyperhidrosis Absent eyebrow Hypothyroidism[] Pachyonychia congenita Clinical features of pachyonychia congenita Palms and soles Thickened or calloused palms and soles (palmoplantar hyperkeratosis or keratoderma , particularly[]

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