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20 Possible Causes for Focal Keratoderma of Soles, Jaundice

  • Growth Hormone Deficiency

    Palmoplantar keratoderma (PPK) is a diverse group of disorders, characterized by thickening of the palms and soles, which are subdivided into focal or diffuse; it can be acquired[ncbi.nlm.nih.gov] The proband is a 5-year-old girl who presented with neonatal hypoglycaemia and prolonged jaundice.[ncbi.nlm.nih.gov] […] may point to intracranial lesions (anosmia or visual deficits) are findings that require exclusion of GHD as the underlying cause, while neonatal signs include prolonged jaundice[symptoma.com]

  • Evan's Syndrome

    Clinical description Tylosis (hyperkeratosis palmaris et plantaris) is a focal, non-epidermolytic form of keratoderma characterised by areas of yellowish thickened plaques[ojrd.biomedcentral.com] A man aged 35 years with a history of Evan's syndrome presented to the clinic with jaundice and shortness of breath, with further testing indicating a relapse of his previously[ncbi.nlm.nih.gov] He was pale, jaundiced, with multiple petechia and generalized joint hypermobility.[cags.org.ae]

  • Howell-Evans Syndrome

    Focal keratodermas are palmoplantar keratodermas (PPK) that involve only some areas of the palms or soles, usually over pressure points.[dermnetnz.org] It can be characterized by varying degrees of anemia, jaundice, an enlarged spleen, or combinations of these conditions.[pedsinreview.aappublications.org] […] abnormalities; death most commonly occurs in childhood as a result of infection or of the "accelerated phase" In the terminal "accelerated phase", patients develop fever, jaundice[stmina-monastery.org]

  • Palmoplantar Keratosis

    […] x-linked dominant condition that begins in early childhood with thick focal keratoderma over the soles and, to a lesser extent, the palms.[en.wikipedia.org] Less commonly the condition may present due to spread elsewhere such as the lungs (breathlessness, cough), liver (jaundice, abdominal swelling due to fluid, ascites), bones[ojrd.biomedcentral.com] Avoid in newborns due to the potential for an increase in free bilirubin, jaundice, and development of kernicterus.[naturallivingcenter.net]

  • Gastrointestinal Disorder

    Necrolytic migratory erythema due to glucagonoma Tylosis Tylosis is an autosomal dominant form of focal, non-frictional and nonepidermolytic, palmoplantar keratoderma.[dermnetnz.org] […] depressed mood, thoughts of suicide or hurting yourself; restless muscle movements in your eyes, tongue, jaw, or neck; hyperactivity, agitation, hostility; hallucinations; jaundice[420evaluationsonline.com] When the pancreas is unable to secrete digestive enzymes, such as with a pancreatic cancer occluding the pancreatic duct, result in jaundice.[en.wikipedia.org]

  • Erythema Palmaris Hereditarium

    […] involving the whole of the palms and soles. [1] :506–8 [2] :213 Focal Focal palmoplantar keratoderma, a type of palmoplantar keratoderma in which large, compact masses of[ipfs.io] Chronic Liver Disease can give rise to numerous extrahepatic disorders among which skin disease occupy a central place Jaundice, xerosis, pruritis, pigmentary changes, loss[medical-dictionary.thefreedictionary.com] […] involving the whole of the palms and soles. [1] : 506–8 [2] : 213 Focal [ edit ] Focal palmoplantar keratoderma, a type of palmoplantar keratoderma in which large, compact[en.wikipedia.org]

  • Jejunal Vascular Anomaly with Hemorrhage

    Necrolytic migratory erythema due to glucagonoma Tylosis Tylosis is an autosomal dominant form of focal, non-frictional and nonepidermolytic, palmoplantar keratoderma.[dermnetnz.org] Flatulence • Palliative resection -Dyspepsia • Palliative bypassLate signs - LOW -anemia -dysphagia -vomiting -epigastric/back pain - epigastric mass -sign of metastases (jaundice[slideshare.net] Other clinical signs are more exceptional: jaundice by pancreatobiliary reflux secondary to clot formation [ 1 et 2 ] , vomiting, weight loss, palpable pulsating epigastric[em-consulte.com]

  • Papillon Lefevre Disease

    Focal keratodermas mainly affect pressure areas. Punctate-type keratodermas result in tiny bumps on the palms and soles.[dermnetnz.org] The pain, which was dull, achy, intermittent, but not radiating, was not associated with vomiting, diarrhea, or jaundice.[pediatrics.aappublications.org] Palmar-plantar hyperkeratosis Group of disorders known as palmar plantar keratodermas (PPK) are characterized by diffuse or localized hyperkeratosis of the palms and soles[de.slideshare.net]

  • Pachyonychia Congenita Type 1

    Fig 2: Showing focal keratoderma on soles. Fig 3: Showing pachyonychia in hands and feet. Fig 4: Showing leukoplakia on tongue and angular cheilitis of mouth.[edoj.org.eg] […] stature Global developmental delay Hydrocephalus Renal insufficiency Hypoglycemia Macrotia Hydronephrosis Feeding difficulties in infancy Intellectual disability, moderate Jaundice[mendelian.co] Pachyonychia congenita Clinical features of pachyonychia congenita Palms and soles Thickened or calloused palms and soles (palmoplantar hyperkeratosis or keratoderma , particularly[dermnetnz.org]

  • Pachyonychia Congenita

    Fig 2: Showing focal keratoderma on soles. Fig 3: Showing pachyonychia in hands and feet. Fig 4: Showing leukoplakia on tongue and angular cheilitis of mouth.[edoj.org.eg] Avoid in newborns due to the potential for an increase in free bilirubin, jaundice, and development of kernicterus.[simplygoodnaturalfoods.com] The predominant features common to both types are thick nails (hypertrophic nail dystrophy), thick skin on the palms and soles (focal palmoplantar keratoderma) and a white[metrohealth.net]

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