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39 Possible Causes for Focal Keratoderma of Soles, Nail Abnormality

  • Pachyonychia Congenita

    Fig 2: Showing focal keratoderma on soles. Fig 3: Showing pachyonychia in hands and feet. Fig 4: Showing leukoplakia on tongue and angular cheilitis of mouth.[edoj.org.eg] Pachyonychia congenita type I is an autosomal dominant disorder where nail abnormalities are a constant feature and develop during childhood.[ncbi.nlm.nih.gov] The predominant features common to both types are thick nails (hypertrophic nail dystrophy), thick skin on the palms and soles (focal palmoplantar keratoderma) and a white[metrohealth.net]

  • Pachyonychia Congenita Type 1

    Fig 2: Showing focal keratoderma on soles. Fig 3: Showing pachyonychia in hands and feet. Fig 4: Showing leukoplakia on tongue and angular cheilitis of mouth.[edoj.org.eg] No nail abnormalities were observed even one year after stopping treatment. Two major subtypes of pachyonychia congenita are recognized.[ijdvl.com] Pachyonychia congenita Clinical features of pachyonychia congenita Palms and soles Thickened or calloused palms and soles (palmoplantar hyperkeratosis or keratoderma , particularly[dermnetnz.org]

  • Papillon Lefevre Disease

    Focal keratodermas mainly affect pressure areas. Punctate-type keratodermas result in tiny bumps on the palms and soles.[dermnetnz.org] abnormalities PROGNOSIS Individuals with the disorder lose their primary teeth by age 5 and lose their permanent teeth during adolescence.[evolvegene.com] Palmar-plantar hyperkeratosis Group of disorders known as palmar plantar keratodermas (PPK) are characterized by diffuse or localized hyperkeratosis of the palms and soles[de.slideshare.net]

  • Epidermolysis Bullosa

    ., belt line) Generalized Generalized Generalized Grouped (herpetiform) No No Sometimes Yes Mucosal Rare Occasionally Occasionally Often Hyperkeratosis of palms & soles (keratoderma[ncbi.nlm.nih.gov] In less severe forms of junctional EB, skin fragility is accompanied by dental enamel defects, nail abnormality and loss, and sometimes sparse hair. What are the causes?[cafamily.org.uk] Nail abnormalities along with multiple cutaneous bullae and erosions were a prominent early physical finding in this cohort, with 6 of 10 patients overall developing nail[jamanetwork.com]

  • Lamellar Ichthyosis

    […] and soles ( Lucker et al., 1994 ).For a discussion of phenotypic and genetic heterogeneity of palmoplantar keratoderma, see epidermolytic PPK ( OMIM ).[mendelian.co] We present the case of a young woman with the following features: lamellar ichthyosis, dwarfism, mental retardation, nail and dental abnormalities, unusual facies, poor sexual[ncbi.nlm.nih.gov] OBJECTIVES: (i) To ascertain whether TGM1 is important for CE formation in nail; (ii) to characterize CE abnormalities occurring in LI that may be distinguished from other[ncbi.nlm.nih.gov]

  • Palmoplantar Keratosis

    […] x-linked dominant condition that begins in early childhood with thick focal keratoderma over the soles and, to a lesser extent, the palms.[en.wikipedia.org] Other clinical features are sclerodactyly and nail abnormalities (hypoplasia, fissuring, ridging, koilonychia).[intechopen.com] Focal keratodermas mainly affect pressure areas. Punctate-type keratodermas result in tiny bumps on the palms and soles.[dermnetnz.org]

  • Diffuse Palmoplantar Keratoderma

    […] involving the whole of the palms and soles. [1] : 506-8 [2] : 213 Focal Focal palmoplantar keratoderma, a type of palmoplantar keratoderma in which large, compact masses[like2do.com] Other clinical features include sclerodactyly and nail abnormalities (hypoplasia, fissuring, ridging, koilonychia).[emedicine.medscape.com] Nail abnormalities. Decreased sweating.[firstskinfoundation.org]

  • Punctate Palmoplantar Keratoderma Type 1

    […] involving the whole of the palms and soles. [1] : 506–8 [2] : 213 Focal [ edit ] Focal palmoplantar keratoderma, a type of palmoplantar keratoderma in which large, compact[en.wikipedia.org] Finally, there were no nail abnormalities. Figure 2 Clinical presentation of the PPK phenotype.[jmg.bmj.com] abnormalities such as longitudinal fissures, onychogryphosis, and onychomadesis are frequently reported. 4,10 The course of the disease is long-term, and spontaneous resolution[mdedge.com]

  • Pachyonychia Congenita Type 2

    Fig 2: Showing focal keratoderma on soles. Fig 3: Showing pachyonychia in hands and feet. Fig 4: Showing leukoplakia on tongue and angular cheilitis of mouth.[edoj.org.eg] The abnormal appearance of the nails can also cause social and psychological problems.[socialstyrelsen.se] The predominant features common to both types are thick nails (hypertrophic nail dystrophy), thick skin on the palms and soles (focal palmoplantar keratoderma) and a white[metrohealth.net]

  • Powell-Venencie-Gordon Syndrome

    […] disease characterized by discrete, focal, punctate keratoderma on the palms and soles and/or slowly progressive spastic paralysis, predominantly affecting the lower limbs[orpha.net] Nail dystrophy affects both toes and fingers; it can be present at birth or developed during early childhood.[accessanesthesiology.mhmedical.com] Homepage Rare diseases Search Search for a rare disease Palmoplantar keratoderma-spastic paralysis syndrome Disease definition A rare, genetic punctate palmoplantar keratoderma[orpha.net]

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