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31 Possible Causes for Focal Keratoderma of Soles, Thin Skin

  • Growth Hormone Deficiency

    Palmoplantar keratoderma (PPK) is a diverse group of disorders, characterized by thickening of the palms and soles, which are subdivided into focal or diffuse; it can be acquired[ncbi.nlm.nih.gov] skin Elevated triglyceride levels Fatigue and/or tiredness Heart problems High levels of LDL (the "bad") cholesterol Insulin resistance Lower tolerance to exercise Reduced[endocrineweb.com] Symptoms of GHD in adults include: Increased fat, especially around the waist Lower muscle mass and strength Mild bone loss Thinning skin Sleep problems Decreased exercise[hormone.org]

  • Epidermolysis Bullosa

    ., belt line) Generalized Generalized Generalized Grouped (herpetiform) No No Sometimes Yes Mucosal Rare Occasionally Occasionally Often Hyperkeratosis of palms & soles (keratoderma[ncbi.nlm.nih.gov] […] on the feet or hands Thin skin appearance and white bumps Difficulty swallowing The symptoms vary from the different types. 7.[de.slideshare.net] They typically include: blistering on the skin, scalp, and around the eyes and nose tearing of the skin skin that looks very thin skin that falls off alopecia, or hair loss[medicalnewstoday.com]

  • Epidermolysis Bullosa Simplex Type Cockayne-Touraine

    ., belt line) Generalized Generalized Generalized Grouped (herpetiform) No No Sometimes Yes Mucosal Rare Occasionally Occasionally Often Hyperkeratosis of palms & soles (keratoderma[ncbi.nlm.nih.gov] Generalized hirsutism Thin skin Sudden cardiac death Cirrhosis Hepatic steatosis Abnormality of the liver Carcinoma Edema Pica Squamous cell carcinoma Tongue atrophy Need[mendelian.co] […] on the palms and soles of the feet); scarring alopecia (scalp blistering, scarring and hair loss); atrophic scarring (thin-appearing skin); milia (small white pimples on[studyres.com]

  • Diffuse Palmoplantar Keratoderma

    […] involving the whole of the palms and soles. [1] : 506-8 [2] : 213 Focal Focal palmoplantar keratoderma, a type of palmoplantar keratoderma in which large, compact masses[like2do.com] They may affect the knuckle pads and nails but do not involve the thin skin on the top of the feet or hands.[dermnetnz.org] It may affect the knuckle pads and nails, but usually does not involve the thin skin on the top of the feet or hands.[rarediseases.info.nih.gov]

  • Ovarian Cyst

    Pachyonychia congenita Clinical features of pachyonychia congenita Palms and soles Thickened or calloused palms and soles ( palmoplantar hyperkeratosis or keratoderma, particularly[dermnetnz.org] Using too much ointment can worsen the problem by thinning the vulvar skin (University of Iowa, 1999b).[web.archive.org] Cystic Teratomas) Dermoid cysts contain mature tissue of ectodermal (eg, skin, hair), mesodermal (eg, muscle, urinary), and endodermal (eg, gastrointestinal, lung) origin[clevelandclinicmeded.com]

  • Palmoplantar Keratosis

    […] x-linked dominant condition that begins in early childhood with thick focal keratoderma over the soles and, to a lesser extent, the palms.[en.wikipedia.org] During 3 rd year of his life he started developing fissures in skin of palms and soles that resulted in peeling off of skin leaving red thin skin underneath.[ayubmed.edu.pk] This thins the affected skin. Treatment has to be closely monitored to avoid excessive thinning of the skin and various side-effects of the drug.[ichthyosis.org.uk]

  • Papillon Lefevre Disease

    Focal keratodermas mainly affect pressure areas. Punctate-type keratodermas result in tiny bumps on the palms and soles.[dermnetnz.org] During 3 rd year of his life he started developing fissures in skin of palms and soles that resulted in peeling off of skin leaving red thin skin underneath.[ayubmed.edu.pk] They may affect the knuckle pads and nails but do not involve the thin skin on the top of the feet or hands.[dermnetnz.org]

  • Erythema Palmaris Hereditarium

    […] involving the whole of the palms and soles. [1] :506–8 [2] :213 Focal Focal palmoplantar keratoderma, a type of palmoplantar keratoderma in which large, compact masses of[ipfs.io] Episodic abdominal pain Parathyroid hyperplasia Growth hormone excess Vomiting Hypertrichosis Thin skin Generalized hirsutism Skin vesicle Fragile skin Atypical scarring[mendelian.co] […] involving the whole of the palms and soles. [1] : 506–8 [2] : 213 Focal [ edit ] Focal palmoplantar keratoderma, a type of palmoplantar keratoderma in which large, compact[en.wikipedia.org]

  • Pachyonychia Congenita Type 1

    Fig 2: Showing focal keratoderma on soles. Fig 3: Showing pachyonychia in hands and feet. Fig 4: Showing leukoplakia on tongue and angular cheilitis of mouth.[edoj.org.eg] skin Papule Pruritus Chronic diarrhea Skin rash Hepatosplenomegaly Severe short stature Pneumonia Thrombocytopenia Fever Jejunal atresia Abnormality of the metaphysis Short[mendelian.co] Pachyonychia congenita Clinical features of pachyonychia congenita Palms and soles Thickened or calloused palms and soles (palmoplantar hyperkeratosis or keratoderma , particularly[dermnetnz.org]

  • Epidermolysis Bullosa Simplex

    ., belt line) Generalized Generalized Generalized Grouped (herpetiform) No No Sometimes Yes Mucosal Rare Occasionally Occasionally Often Hyperkeratosis of palms & soles (keratoderma[ncbi.nlm.nih.gov] […] on the feet or hands Thin skin appearance and white bumps Difficulty swallowing The symptoms vary from the different types. 7.[slideshare.net] They typically include: blistering on the skin, scalp, and around the eyes and nose tearing of the skin skin that looks very thin skin that falls off alopecia, or hair loss[medicalnewstoday.com]

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