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161 Possible Causes for Focal Parakeratosis

  • Pityriasis Rubra Pilaris

    Histopathology showed mild to moderate hyperkeratosis with focal parakeratosis and hypergranulosis.[] PRP patient with alternating ortho and parakeratosis, focal follicular plugging Differential diagnosis Psoriasis: acanthosis is more marked, and often strikingly regular,[] A biopsy of affected skin from the proband, a 5-year-old girl, revealed hyperkeratosis with focal parakeratosis, follicular plugging, and moderate acanthosis.[]

  • Familial Reactive Perforating Collagenosis

    The epidermis around invagination showed moderate psoriasiform hyperplasia, acanthosis, mild spongiosis, and focal parakeratosis [Figure 6] .[] Biopsy taken from one of the papule from right leg showed irregular epithelial hyperplasia with follicular cornified plug and focal parakeratosis.[] Figure 1: Multiple discrete hyperkeratotic papules on bilateral lowerlimbs Click here to view Figure 3: Follicular cornified plug with focal parakeratosis (H and E, 4) Click[]

  • Erythrokeratoderma

    A biopsy was performed that showed papillated epidermal hyperplasia, hypergranulosis, compact orthokeratosis, and focal parakeratosis.[]

  • Acute Generalized Exanthematous Pustulosis

    Fig. 2 Histopathology of skin biopsy revealing spongiotic epidermis with focal parakeratosis, exocytosis, and spongiotic vesicles, along with papillary dermal edema, superficial[]

  • Acquired Ichthyosis

    Three of them presented focal parakeratosis.[]

  • Penile Intraepithelial Neoplasia

    Epidermal psoriasiform hyperplasia, hyperkeratosis, and focal parakeratosis are also common features.[]

  • Laryngeal Papilloma

    Dyskeratotic cells are seen focally. Parakeratosis is present. Koilocytes are seen focally. See also Head and neck pathology .[] Dyskeratotic cells are seen focally. Parakeratosis is present. Koilocytes are not apparent.[]

  • Erythema Annulare Centrifugum

    Histopathology from the erythematous margin showed mild hyperkeratosis, focal parakeratosis, and perivascular lymphocytic infiltrate in the superficial as well as deep dermis[] In the biopsy, there was mild spongiosis and focal parakeratosis [Figure 3] . In dermis, mild periappendageal lymphocytic infiltrate was seen [Figure 4] .[] ; may have focal vacuolar changes Microscopic (histologic) images Images hosted on PathOut server: Case of the Week #71: Images hosted on other servers: Erythema annulare[]

  • Bazex Syndrome

    Histopathologically, there was hyperkeratosis, focal parakeratosis, small pustular change and perivascular lymphocytic infiltrate in the papillary dermis.[]

  • Pityriasis Lichenoides

    Histologic Features Focal parakeratosis A slightly thin epidermis Vacuolar alteration of the basal layer Necrotic keratinocytes in variable numbers within the epidermis A[] parakeratosis, preservation of the granular layer, and focal disappearance of the dermal-epidermal interface Management The course of pityriasis lichenoides varies with an[] The histological signs of acute pityriasis lichenoides are focal parakeratosis with neutrophils in the flakes, intense spongiosis, abundant necrotic keratinocytes and numerous[]

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