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20 Possible Causes for Focal Parakeratosis, Mild to Moderate Hyperkeratosis

  • Pityriasis Rubra Pilaris

    Histopathology showed mild to moderate hyperkeratosis with focal parakeratosis and hypergranulosis.[omim.org] Histopathology of involved skin showed focal parakeratosis and orthokeratosis alternating in both horizontal and vertical directions with an underlying perivascular inflammatory[casereports.bmj.com] PRP patient with alternating ortho and parakeratosis, focal follicular plugging Differential diagnosis Psoriasis: acanthosis is more marked, and often strikingly regular,[pathologyoutlines.com]

  • Gianotti-Crosti Syndrome

    Biopsy of the skin lesion shows hyperkeratosis with mild to moderate acanthosis, papillary dermal edema and superficial perivascular infiltrate of mononuclear cells and histiocytes[ijdvl.com] The histopathologic findings are nonspecific and include focal parakeratosis, mild spongiosis, superficial perivascular infiltrate, papillary dermal edema, and extravasated[ncbi.nlm.nih.gov] parakeratosis and epidermal spongiosis.[ncbi.nlm.nih.gov]

  • Generalized Follicular Keratosis

    They can range from topical ointments for mild to moderate cases, to light therapy and oral or injected medications for more severe cases.[healthline.com] Histopathological examination revealed a hyperkeratosis with a focal parakeratosis overlying the thinned epidermis.[connection.ebscohost.com] Histopathological examination of skin biopsies obtained from the trunk and extremities showed prominent hyperkeratosis and follicular plugging with focal parakeratosis.[ijdvl.com]

  • Annular Epidermolytic Ichthyosis

    Lamellar Ichthyosis : The transglutaminase-1 can be stained in frozen sections of skin; histology shows orthokeratotic hyperkeratosis and mild to moderate acanthosis.[slideshare.net] parakeratosis in accordance with only countable cases reported worldwide. granular degeneration.[deepdyve.com] Epidermolytic hyperkeratosis : H/E shows compact hyperkeratosis. Granular layer is markedly thickened and contains coarse keratohyaline granules.[slideshare.net]

  • Erythrokeratoderma

    During the 1 year follow-up period, he occasionally had episodes of erythema and mild degree of hyperkeratosis.[idoj.in] A biopsy was performed that showed papillated epidermal hyperplasia, hypergranulosis, compact orthokeratosis, and focal parakeratosis.[the-medical-dictionary.com] Figure 4: Hyperkeratosis with moderate papillomatozis and acanthosis are shown (H and E, 10) Click here to view There are two major subtypes of EKV: (1) EK variabilis (Mendes[idoj.in]

  • Palmoplantar Keratosis

    A, A biopsy specimen from the dorsum of the hand shows orthokeratotic hyperkeratosis with acanthosis, hypergranulosis, and mild perivascular inflammatory infiltration.[jamanetwork.com] Moreover, a transitional cell zone, focal parakeratosis with lipid droplets, and dyskeratotic cells became apparent.[journals.lww.com] […] epidermolytic hyperkeratosis Continuous epidermolytic hyperkeratosis Mosaic Epidermolytic ichthyosis Parakeratosis, hypergranulosis and vacuolar degeneration of granular[pathologyoutlines.com]

  • Ectodermal Dysplasia-Sensorineural Deafness Syndrome

    Genetic analysis of the connexin-26 M34T variant: identification of genotype M34T/M34T segregating with mild-moderate non-syndromic sensorineural hearing loss.[davinci.crg.es] Histopathological examination of plantar skin showed hyperkeratosis, focal parakeratosis, acanthosis and spongiosis.[bioline.org.br] Heathcote et al 2000 A connexin 26 mutation causes a syndrome of sensorineural hearing loss and palmoplantar hyperkeratosis J Med Genet 2000, 37:50-51 Houseman et al 2001[davinci.crg.es]

  • MEDNIK Syndrome

    Lifelong erythroderma, scaling Variable palmoplantar involvement Birth Yes No I No moderate hyperkeratosis, normal/slightly thickened granular cell layer, mild acanthosis,[clinicaladvisor.com] […] areas of parakeratosis and thickened granual layer.[clinicaladvisor.com] parakeratosis, hypergranulosis, papillomatous acanthosis.[clinicaladvisor.com]

  • Palmoplantar Keratoderma-Spastic Paralysis Syndrome

    Lifelong erythroderma, scaling Variable palmoplantar involvement Birth Yes No I No moderate hyperkeratosis, normal/slightly thickened granular cell layer, mild acanthosis,[dermatologyadvisor.com] (Axillary granular parakeratosis, Intertriginous granular parakeratosis) Keratolysis exfoliativa (Lamellar dyshidrosis, Recurrent focal palmar peeling, Recurrent palmar peeling[doctors-hospitals-medical-cape-town-south-africa.blaauwberg.net] […] areas of parakeratosis and thickened granual layer.[dermatologyadvisor.com]

  • Focal Nonepidermolytic Palmoplantar Keratoderma

    Lifelong erythroderma, scaling Variable palmoplantar involvement Birth Yes No I No moderate hyperkeratosis, normal/slightly thickened granular cell layer, mild acanthosis,[dermatologyadvisor.com] […] epidermolytic hyperkeratosis Continuous epidermolytic hyperkeratosis Mosaic Epidermolytic ichthyosis Parakeratosis, hypergranulosis and vacuolar degeneration of granular[pathologyoutlines.com] […] areas of parakeratosis and thickened granual layer.[dermatologyadvisor.com]

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