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83 Possible Causes for Focal Sharp-and-Slow-Waves

  • Epilepsy

    Pathologic slowing, when localized, often correlates with focal brain lesions; when diffuse, slow activity often signifies an encephalopathy.[] No focal signs or dysmorphic features were evident. EEG at 11 months showed right central high voltage slowing and sharp waves, and at 2.5 years, was unremarkable.[] Epileptiform activity characteristic of people with epilepsy includes abnormalities such as spikes, sharp waves and spike-wave complexes, ( slides 21 & 22 ). IV.[]

  • Ohtahara Syndrome

    No focal signs or dysmorphic features were evident. EEG at 11 months showed right central high voltage slowing and sharp waves, and at 2.5 years, was unremarkable.[]

  • Panayiotopoulos Syndrome

    Interictal EEG shows occipital spikes although multifocal spikes with high amplitude sharp-slow wave complexes at various locations can be present.[] Multifocal high voltage repetitive spikes or sharp and slow-waves are seen in 90% of patients; these often are present in different focal areas on sequential EEGs.[] Abstract Panayiotopoulos syndrome is a relatively frequent and benign epileptic syndrome, characterised by predominantly autonomic symptoms and/or simple motor focal seizures[]

  • Rolandic Epilepsy

    The EEG feature of sharp-slow waves originating from the rolandic region is the unifying feature.[] The idiopathic focal epilepsies are a group of childhood seizure disorders ranging from mild, self-limiting rolandic epilepsy to severe epileptic encephalopathies.[]

  • Brain Neoplasm

    Continuum (Minneap Minn). 2015 Apr;21(2 Neuro-oncology):480-6. doi: 10.1212/01.CON.0000464183.35322.5f. Abstract Neurologists are often on the front lines of diagnosis for primary and metastatic brain tumors. Patients with brain tumors typically have multiple comorbidities and pain generators beyond headache,[…][]

  • Lennox-Gastaut Syndrome

    Interictal There may be focal or multifocal spike-and-wave or sharp-slow waves, with an anterior predominance.[] Background The EEG background is abnormal in all cases from onset of seizures, with generalized or focal slowing.[]

  • Early Myoclonic Encephalopathy

    Inter-ictally, clusters of sharp-slow wave focal discharges maximum around the left Rolandic regions (left). They became continuous during natural sleep (right).[]

  • Miller Dieker Syndrome

    EEG patterns of two types are recognized - diffuse, atypical slow sharp/spike-and-wave complexes in long bursts activated by slow wave sleep or high amplitude fast spike/polyspike-and-wave[] Epileptic spasms, atypical absences and focal seizures may also occur.[]

  • Angelman Syndrome

    Angelman syndrome is a rare genetic disorder characterized by severe intellectual and developmental disability, sleep disorder, frequent and sometimes inappropriate laughter, seizures, jerky movements and ataxia. It is named after the British pediatrician, Dr. Harry Angelman, who first described it in 1965. Patients[…][]

  • Creutzfeldt Jakob Disease

    Prion diseases are unique transmissible neurodegenerative diseases that have diverse phenotypes and can be familial, sporadic, or acquired by infection. Recent findings indicate that the PrP genotype and the PrP(Sc) type have a major influence on the disease phenotype in both sporadic and familial human prion[…][]

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