Follicular Hyperkeratosis: Causes & Reasons

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Possible Causes for Follicular Hyperkeratosis

Pityriasis Rubra Pilaris

Pityriasis rubra pilaris (PRP) is a chronic papulosquamous eruption of the skin characterized by follicular hyperkeratosis, salmon pink scaly plaques with islands of unaffected [ncbi.nlm.nih.gov]

The typical features of pityriasis rubra pilaris include follicular hyperkeratosis and a reddish orange, scaling dermatitis with islands of normal skin. [accessmedicine.mhmedical.com]

Cutis. 2012 November;90(5):244-247 Pityriasis rubra pilaris (PRP) is a chronic papulosquamous eruption of the skin characterized by follicular hyperkeratosis, salmon pink [mdedge.com]

Congenital Muscular Dystrophy

Joint hyperlaxity and skin changes (follicular hyperkeratosis and muscle biopsy scar thinning) were unique to COL6A. [ncbi.nlm.nih.gov]

UCMD patients usually have dry soft skin and follicular hyperkeratosis over the extensor surfaces of the extremities. [orpha.net]

Some dermatological symptoms are present as follicular hyperkeratosis and tendency to form adherence in scars. [pepsic.bvsalud.org]

Vitamin A Deficiency

Phrynoderma is a rare form of follicular hyperkeratosis associated with deficiencies in vitamins A or C or essential fatty acids. [ncbi.nlm.nih.gov]

Phrynoderma is a distinctive form of follicular hyperkeratosis associated with nutritional deficiency. [ncbi.nlm.nih.gov]

Malnutrition leads to follicular hyperkeratosis or phrynoderma, manifested by the presence of skin lesions and hyperkeratotic papules. [symptoma.com]

Pachyonychia Congenita

Pachyonychia congenita (PC) is a rare inherited disorder of keratinization characterised by hypertrophic nail dystrophy, painful palmoplantar blisters, cysts, follicular hyperkeratosis [ncbi.nlm.nih.gov]

Pachyonychia congenita is characterized by symmetrical nail dystrophy, palmoplantar keratoderma, oral leukokeratosis, and follicular hyperkeratosis. [ncbi.nlm.nih.gov]

leukokeratosis of the tongue and mucous membranes and follicular hyperkeratosis. [miami.pure.elsevier.com]

Pachyonychia Congenita Type 1

It is not often associated with the additional features of oral leukokeratosis, cysts, follicular hyperkeratosis, and natal teeth. [en.wikipedia.org]

leukokeratosis of the tongue and mucous membranes and follicular hyperkeratosis. [miami.pure.elsevier.com]

There are painful plaques of callus-like hyperkeratosis (keratoderma) on palms and soles with underlying blisters, hyperhidrosis and some individuals may have spiny follicular [genedx.com]

Hereditary Mucoepithelial Dysplasia

HMD should be considered in the differential diagnosis of childhood alopecia, follicular hyperkeratosis, keratoconjunctivitis, juvenile cataracts, gingival hyperemia, restrictive [ncbi.nlm.nih.gov]

Follicular hyperkeratosis can be treated using topical keratolytics, emollients and urea preparations. [ojrd.biomedcentral.com]

In addition, there is a congenital hearing loss, palmoplantar hyperkeratosis with leather grain-like keratoderma is present but no follicular hyperkeratosis, and the mode [ojrd.biomedcentral.com]

Keratosis Pilaris

Keratosis pilaris (KP) is a common inherited disorder of follicular hyperkeratosis It is characterized by small, folliculocentric keratotic papules that may have surrounding [ncbi.nlm.nih.gov]

Histologic examination showed follicular and interfollicular hyperkeratosis, follicular plugging, mild inflammation, and focal scarring. [ncbi.nlm.nih.gov]

This kindred has features of both keratosis follicularis spinulosa decalvans and ichthyosis follicularis, and the disorder seems to fit into the group of follicular hyperkeratosis [ncbi.nlm.nih.gov]

Steatocystoma Multiplex With Natal Teeth

On examination, follicular hyperkeratosis was detected on both ears which was seen to progress to involve her back, buttocks and thighs by 1 year of age. [ijdvl.com]

There are painful plaques of callus-like hyperkeratosis (keratoderma) on palms and soles with underlying blisters, hyperhidrosis and some individuals may have spiny follicular [genedx.com]

Cutaneous manifestations seen in most of the cases of Pachyonychia congenita include palmoplantar keratoderma, follicular hyperkeratosis, wedge shaped nails, oral leukokeratosis [idoj.in]

Monilethrix

Alopecia, associated with follicular hyperkeratosis and perifollicular erythema, can involve only the occiput and the nape of the neck or, in severe forms, the entire scalp [orpha.net]

hyperkeratosis. [ncbi.nlm.nih.gov]

Monilethrix, a rare autosomal dominant disease characterized by hair fragility and follicular hyperkeratosis, is caused by mutations in three type II hair cortex keratins. [ncbi.nlm.nih.gov]

Follicular Lichen Planus

The most common trichoscopic features of FFA include absence of follicular openings, followed by follicular hyperkeratosis, perifollicular erythema, and follicular plugs. [idoj.in]

Histopathologically, perifollicular lymphocytic infiltrate and follicular hyperkeratosis are observed at the edge of the affected area, while the rest of the lesion appears [orpha.net]

The absence of follicular openings, absence of vellus hairs, presence of follicular hyperkeratosis and plugs, and perifollicular scales are dermoscopic hallmarks of FFA. [ [idoj.in]

Pseudopelade of Brocq

Patients present with red plaques of hair loss, atrophy, telangiectasias, and follicular hyperkeratosis. [hairtx.com]

hyperkeratosis or perifollicular inflammation. [orpha.net]

Follicular hyperkeratosis occurs along the periphery of the plaques unlike in lupus. Itchiness and tenderness are common features of LPP. [hairtx.com]

Epidermal Nevus

An uncommon type of epidermal nevus characterized by systematized bands of non-epidermolytic hyperkeratosis with increased hairiness and follicular hyperkeratosis was observed [ncbi.nlm.nih.gov]

Follicular hyperkeratosis was not seen in our patient though. Genetic analysis done from lesional skin showed only wild-type alleles of both FGFR3 and PIK3CA genes. [e-ijd.org]

[…] increased hairiness and follicular hyperkeratosis was observed in a 16-year-old boy who showed, in addition, hemihypoplasia of limbs, brachydactyly, clinodactyly and onychodystrophy [karger.com]

Folliculitis Decalvans

BACKGROUND: Follicular hyperkeratosis along with hyperplasia of the follicular and interfollicular epithelia are major histopathological characteristics of hidradenitis suppurativa [ncbi.nlm.nih.gov]

In conclusion, tufted hairs, perifollicular erythema, and follicular hyperkeratosis are the hallmarks trichoscopic features of FD. [ijtrichology.com]

hyperkeratosis in FD patients. [ncbi.nlm.nih.gov]

Demodicosis

and mild to moderate follicular hyperkeratosis ." ( J1 .29.w13) Hairs mainly in telogen and catagen. ( J1 .29.w13) Mild acanthosis on the forearms. ( J1 .29.w13) Rarely, [wildpro.twycrosszoo.org]

Demodex folliculorum is characterised histologically by: Numerous demodex mites in the infundibula of the follicles Follicular hyperkeratosis Focal follicular lichenoid lymphocytic [dermnetnz.org]

[…] superficial dermatitis and follicular pustules. ( J1 .29.w13) Presence of Demodex sp. mites within hair follicles (more than 20 in a single cross section of some follicles [wildpro.twycrosszoo.org]

Scurvy

A 9-year-old girl had the insidious development of lethargy, gingival erosions, and follicular hyperkeratosis with perifollicular hemorrhage. [ncbi.nlm.nih.gov]

The clinical manifestations of follicular hyperkeratosis, perifollicular petechiae, corkscrew hairs, and easy bruising are due to defective collagen synthesis and can be mistaken [ncbi.nlm.nih.gov]

It classically presents as follicular hyperkeratosis and perifollicular hemorrhage of the lower extremities, as well as bleeding in other areas such as the gingiva and joints [ncbi.nlm.nih.gov]

Idiopathic Recurrent and Disabling Cutaneous Herpes

Follicular hyperkeratosis, most prominent on the nose, is considered a sign of paraneoplastic myeloma. [emedicine.medscape.com]

Syphilitic Alopecia

Dermoscopy shows dilated capillaries and severe follicular hyperkeratosis at the periphery of the patch and absence of follicular ostia in the center (b). [ncbi.nlm.nih.gov]

Diffuse whitish scaling, erythematous background, and focal follicular hyperkeratosis were also observed. [ncbi.nlm.nih.gov]

Moreover, we observed additional features, including tapering hairs, diffuse scaling and focal follicular hyperkeratosis. [ncbi.nlm.nih.gov]

Atrophodermia Vermiculata

Histopathologic examination of the scalp: lamellar hyperkeratosis in the follicular ostium, discreet superficial perivascular mononuclear infiltration and linear scar, vertical [scielo.br]

Patogistologiya : atrophy of epidermis, follicular hyperkeratosis, hypoplasia of sebaceous glands. Forecast in the cosmetic relation for most of patients favorable. [bigmed.info]

A punch biopsy specimen of an atrophic keratotic papule on the upper back showed follicular hyperkeratosis with mild perifollicular fibrosis as well as perifollicular and [omim.org]

Palmoplantar Keratosis

Solar keratosis related: a rare variant of solar keratosis Follicular: nevoid follicular epidermolytic hyperkeratosis Mucosal: epidermolytic leukoplakia Terminology Other [pathologyoutlines.com]

Other cutaneous manifestations include acanthosis nigricans, xerosis, follicular hyperkeratosis over the zygoma, and hyperhidrosis. [emedicine.com]

[…] palmoplantar keratoderma variant (Vorner type) Solitary: epidermolytic acanthoma Multiple discrete: disseminated epidermolytic acanthoma Incidental: focal epidermolytic hyperkeratosis [pathologyoutlines.com]

Subperiosteal Hemorrhage

Follicular hyperkeratosis, coiled hair, and perifollicular hemorrhages may develop. [merckmanuals.com]

Dermatologic manifestations include follicular hyperkeratosis with perifollicular hemorrhage surrounding twisted, brittle hairs (corkscrew hairs), ecchymoses, poor wound healing [blogs.nejm.org]

hyperkeratosis, coiled hair, swollen and bleeding gums, loose teeth, poor wound healing, and spontaneous hemorrhages. [merckmanuals.com]

Ichthyosis Follicularis - Alopecia - Photophobia Syndrome

Follicular hyperkeratosis can be treated using topical keratolytics, emollients and urea preparations. [paperity.org]

hyperkeratosis, chronic candidiasis, keratitis, seizures, mental retardation and inguinal hernia: a severe manifestation of IFAP syndrome? [ipfs.io]

Inheritance in Man), Johns Hopkins University, Ichthyosis follicularis, atrichia and photophobia ^ Boente M del, Bibas-Bonet H, Coronel AM, Asial RA; Atrichia, ichthyosis, follicular [en.wikipedia.org]

X-Linked Keratosis Follicularis Spinulosa Decalvans

hyperkeratosis, progressive scarring alopecia of scalp, eyebrows, and eyelashes and may be accompanied by photophobia, corneal and conjunctival inflammation and dystrophy [mona.uwi.edu]

Follicular hyperkeratosis begins during infancy or early childhood, first on the face, affected the eyebrows, cheeks, forehead, and nose. [ncbi.nlm.nih.gov]

Follicularis Spinulosa Decalvans Associated wıth Leukonychia The Editor, Sir, Keratosis follicularis spinulosa decalvans (KFSD) is a rare X-linked disorder characterized by diffuse follicular [mona.uwi.edu]

Ehlers-Danlos Syndrome Kyphoscoliotic Type 2

Additional findings may include follicular hyperkeratosis and crisscross palms/soles. [ncbi.nlm.nih.gov]

hyperkeratosis Bladder diverticula Other suggestive findings Marfanoid habitus Pectus deformity Talipes equinovarus Skin hyperextensibility Easily bruisable skin Hernia [ncbi.nlm.nih.gov]

hyperkeratosis Myopathy on muscle biopsy 1 Respiratory muscle failure Absence of skin hyperelasticity & easy bruising Absence of hearing impairment & cardiovascular problems [ncbi.nlm.nih.gov]

IFAP Syndrome with or without BRESHEK Syndrome

hyperkeratosis, chronic candidiasis, keratitis, seizures, mental retardation and inguinal hernia: a severe manifestation of IFAP syndrome? [en.wikipedia.org]

Follicular hyperkeratosis can be treated using topical keratolytics, emollients and urea preparations. [ojrd.biomedcentral.com]

Generalized follicular hyperkeratosis is present on the scalp, dorsal surface of the limbs and on the abdomen. Most patients are completely bald. [disorders.eyes.arizona.edu]

Autosomal Recessive Pachyonychia Congenita

leukokeratosis of the tongue and mucous membranes and follicular hyperkeratosis. [miami.pure.elsevier.com]

We present a 6-year-old girl with hypertrophic nail dystrophy, follicular hyperkeratosis, circumscribed plantar keratoderma and oral leukokeratosis. [content.sciendo.com]

[…] four patients, 2 males and 2 females, ranging in age from 13 to 50 years, were referred to our Department because of dystrophic lesions in twenty nails, palmar and plantar hyperkeratosis [miami.pure.elsevier.com]

Pachyonychia Congenita Type 2

hyperkeratosis. [yonsei.pure.elsevier.com]

[…] included early onset steatocystoma multiplex and Hutchinson-like tooth deformities along with other typical features of PC-2 such as hypertrophic nails, natal teeth and follicular [yonsei.pure.elsevier.com]

Vitamin C Deficiency

Follicular hyperkeratosis, coiled hair, and perifollicular hemorrhages may develop. [merckmanuals.com]

hyperkeratosis, coiled hair, swollen and bleeding gums, loose teeth, poor wound healing, and spontaneous hemorrhages. [merckmanuals.com]

[…] weeks or months, the deficiency causes nonspecific symptoms (eg, weakness, lassitude, irritability, arthralgias, myalgias); later, connective tissue is affected, causing follicular [merckmanuals.com]

Pyoderma Gangrenosum - Acne - Suppurative Hidradenitis

The earliest change is plugging, which occurs in follicular hyperkeratosis with infundibulofolliculitis. [emedicine.medscape.com]

hyperkeratosis. [26] An abnormal end-organ response to normal circulating levels of androgens is proposed. [46] The normal apocrine gland contains 5-alpha reductase, which [emedicine.medscape.com]

while these parameters may influence preexisting disease, they are unlikely to be pathogenically important. [49] In obesity, increased skin-to-skin contact may promote follicular [emedicine.medscape.com]

Congenital Muscular Dystrophy Type Ullrich

Follicular hyperkeratosis on extensor aspect of limbs. Development : Motor delay. Normal intelligence. References & Further reading Reed UC, et al. [genetics4medics.com]

UCMD patients usually have dry soft skin and follicular hyperkeratosis. Early respiratory failure is common and potential cause of death. [link.springer.com]

In addition, some people have skin abnormalities as follicular hyperkeratosis that develops around the elbows and knees. [ivami.com]

Focal Non-Epidermolytic Palmoplantar Keratoderma

hyperkeratosis. [ncbi.nlm.nih.gov]

There were no nail changes, subungeal keratoses, or follicular hyperkeratosis. [ncbi.nlm.nih.gov]

hyperkeratosis, and oral leukokeratosis. [genecards.org]