Follicular-hyperkeratosis: Causes & Reasons

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Possible Causes for follicular hyperkeratosis

Congenital Muscular Dystrophy

Joint hyperlaxity and skin changes (follicular hyperkeratosis and muscle biopsy scar thinning) were unique to COL6A. [ncbi.nlm.nih.gov]

UCMD patients usually have dry soft skin and follicular hyperkeratosis over the extensor surfaces of the extremities. [orpha.net]

Other characteristic findings include protrusion of the calcanei, follicular hyperkeratosis, and a predisposition to hypertrophie (keloid) scars.19,20 Serum creatine kinase [healio.com]

Pityriasis Rubra Pilaris

Pityriasis rubra pilaris (PRP) is a chronic papulosquamous eruption of the skin characterized by follicular hyperkeratosis, salmon pink scaly plaques with islands of unaffected [ncbi.nlm.nih.gov]

All patients promptly showed a decrease in erythema, follicular hyperkeratosis and scaling. [ncbi.nlm.nih.gov]

The typical features of pityriasis rubra pilaris include follicular hyperkeratosis and a reddish orange, scaling dermatitis with islands of normal skin. [accessmedicine.mhmedical.com]

Vitamin A Deficiency

Phrynoderma is a rare form of follicular hyperkeratosis associated with deficiencies in vitamins A or C or essential fatty acids. [ncbi.nlm.nih.gov]

Phrynoderma is a distinctive form of follicular hyperkeratosis associated with nutritional deficiency. [ncbi.nlm.nih.gov]

Poor adaptation to darkness (nyctalopia) Dry skin Dry hair Pruritus Broken fingernails Keratomalacia Xerophthalmia Corneal perforation Follicular hyperkeratosis (phrynoderma [emedicine.medscape.com]

Pachyonychia Congenita

Pachyonychia congenita (PC) is a rare inherited disorder of keratinization characterised by hypertrophic nail dystrophy, painful palmoplantar blisters, cysts, follicular hyperkeratosis [ncbi.nlm.nih.gov]

Pachyonychia congenita is characterized by symmetrical nail dystrophy, palmoplantar keratoderma, oral leukokeratosis, and follicular hyperkeratosis. [ncbi.nlm.nih.gov]

[…] outer root sheath keratinocytes, and moderate parakeratotic and orthokeratotic follicular hyperkeratosis. [ncbi.nlm.nih.gov]

Pachyonychia Congenita Type 1

Using an effectiveness scale of 1 to 5, the patients were asked to grade treatments for different manifestations, including keratoderma, cysts, follicular hyperkeratosis, [doi.org]

There are painful plaques of callus-like hyperkeratosis (keratoderma) on palms and soles with underlying blisters, hyperhidrosis and some individuals may have spiny follicular [genedx.com]

It is not often associated with the additional features of oral leukokeratosis, cysts, follicular hyperkeratosis, and natal teeth. [en.wikipedia.org]

Keratosis Pilaris

Keratosis pilaris (KP) is a common inherited disorder of follicular hyperkeratosis It is characterized by small, folliculocentric keratotic papules that may have surrounding [ncbi.nlm.nih.gov]

Histologic examination showed follicular and interfollicular hyperkeratosis, follicular plugging, mild inflammation, and focal scarring. [ncbi.nlm.nih.gov]

This kindred has features of both keratosis follicularis spinulosa decalvans and ichthyosis follicularis, and the disorder seems to fit into the group of follicular hyperkeratosis [ncbi.nlm.nih.gov]

Hereditary Mucoepithelial Dysplasia

HMD should be considered in the differential diagnosis of childhood alopecia, follicular hyperkeratosis, keratoconjunctivitis, juvenile cataracts, gingival hyperemia, restrictive [ncbi.nlm.nih.gov]

Examination by the dermatology team revealed follicular hyperkeratosis of the scalp and keratosis pilaris of the arms, legs, and face, but no frank ichthyosis (Figs. 1 and [healio.com]

Ichthyosis Vulgaris

The face is generally spared; however, hyperkeratosis of the palms and soles and follicular hyperkeratosis of the cheek and neck is often present. Pruritus is frequent. [accessanesthesiology.mhmedical.com]

Dry, scaly scalp Overgrowth (hyperkeratosis) of the skin on the palms and soles Cracked skin creases, which may crack more during dry weather Keratosis pilaris (follicular [verywellhealth.com]

Ichthyosis vulgaris is associated with keratosis pilaris (follicular hyperkeratosis) and hyperlinearity (pronounced skin lines) of palms and soles. [dermnetnz.org]

Ovarian Cyst

hyperkeratosis) Tends to become less obvious in adult life Mouth White patches on tongue and inside cheeks (leukokeratosis) Sores at sides of mouth ( angular cheilitis ) [dermnetnz.org]

hyperkeratosis. [onlinelibrary.wiley.com]

There are painful plaques of callus-like hyperkeratosis (keratoderma) on palms and soles with underlying blisters, hyperhidrosis and some individuals may have spiny follicular [genedx.com]

Monilethrix

Alopecia, associated with follicular hyperkeratosis and perifollicular erythema, can involve only the occiput and the nape of the neck or, in severe forms, the entire scalp [orpha.net]

hyperkeratosis. [ncbi.nlm.nih.gov]

Monilethrix, a rare autosomal dominant disease characterized by hair fragility and follicular hyperkeratosis, is caused by mutations in three type II hair cortex keratins. [ncbi.nlm.nih.gov]

Epidermal Nevus

An uncommon type of epidermal nevus characterized by systematized bands of non-epidermolytic hyperkeratosis with increased hairiness and follicular hyperkeratosis was observed [ncbi.nlm.nih.gov]

[…] increased hairiness and follicular hyperkeratosis was observed in a 16-year-old boy who showed, in addition, hemihypoplasia of limbs, brachydactyly, clinodactyly and onychodystrophy [karger.com]

Follicular hyperkeratosis was not seen in our patient though. Genetic analysis done from lesional skin showed only wild-type alleles of both FGFR3 and PIK3CA genes. [e-ijd.org]

Folliculitis Decalvans

BACKGROUND: Follicular hyperkeratosis along with hyperplasia of the follicular and interfollicular epithelia are major histopathological characteristics of hidradenitis suppurativa [ncbi.nlm.nih.gov]

In conclusion, tufted hairs, perifollicular erythema, and follicular hyperkeratosis are the hallmarks trichoscopic features of FD. [ijtrichology.com]

hyperkeratosis in FD patients. [ncbi.nlm.nih.gov]

Follicular Lichen Planus

Histopathologically, perifollicular lymphocytic infiltrate and follicular hyperkeratosis are observed at the edge of the affected area, while the rest of the lesion appears [orpha.net]

Follicular hyperkeratosis and erythema were present in 66%, and only 25% of the men reported pruritus. [ncbi.nlm.nih.gov]

[…] pale with loss of the follicular ostia. [orpha.net]

Steatocystoma Multiplex With Natal Teeth

On examination, follicular hyperkeratosis was detected on both ears which was seen to progress to involve her back, buttocks and thighs by 1 year of age. [ijdvl.com]

There are painful plaques of callus-like hyperkeratosis (keratoderma) on palms and soles with underlying blisters, hyperhidrosis and some individuals may have spiny follicular [genedx.com]

Cutaneous manifestations seen in most of the cases of Pachyonychia congenita include palmoplantar keratoderma, follicular hyperkeratosis, wedge shaped nails, oral leukokeratosis [idoj.in]

Pseudopelade of Brocq

hyperkeratosis or perifollicular inflammation. [orpha.net]

Patients present with red plaques of hair loss, atrophy, telangiectasias, and follicular hyperkeratosis. [hairtx.com]

[…] hair abnormality characterized by onset in adulthood of soft, irregular, flesh-toned patches of alopecia primarily in the parietal and vertex portions of the scalp, without follicular [orpha.net]

Acne Vulgaris

Etiology Genetic predisposition Hormonal factors Sebum production In women: menstrual cycle Follicular hyperkeratosis Bacterial colonization; with Cutibacterium acnes (formerly [amboss.com]

It reduces follicular hyperkeratosis by stimulating the turnover of epithelial cells. [apps.who.int]

Upper Urinary Tract Infection

hyperkeratosis 62% 47% 0 14% 68% Natal or prenatal teeth 2% 0 0 0 77% Oral leukokeratosis 88% 31% 19% 41% 27% *IPCRR data summary as of December 2013 *Data from 218, 49, [dermnetnz.org]

hyperkeratosis. [onlinelibrary.wiley.com]

Additional clinical features include follicular hyperkeratosis, leukokeratosis of the oral mucosa, and various cysts (steatocysts and pilosebaceous cysts). [genome.jp]

Syphilitic Alopecia

Dermoscopy shows dilated capillaries and severe follicular hyperkeratosis at the periphery of the patch and absence of follicular ostia in the center (b). [ncbi.nlm.nih.gov]

Diffuse whitish scaling, erythematous background, and focal follicular hyperkeratosis were also observed. [ncbi.nlm.nih.gov]

Moreover, we observed additional features, including tapering hairs, diffuse scaling and focal follicular hyperkeratosis. [ncbi.nlm.nih.gov]

Tonsillitis

Hyperkeratosis Parakeratosis Spongiosis A perivascular inflammatory infiltrate Periodic acid-Schiff stain is a special stain that will help in identifying the fungi. [ncbi.nlm.nih.gov]

[…] of this type: Trichophyton schoenleinii,[4] Histopathology Tinea capitis shows the following histological findings: Subacute and chronic dermatitis either with or without follicular [ncbi.nlm.nih.gov]

Actinic Keratosis

parakeratosis May have atrophy of epidermal surface Usually no granular layer except at follicular orifices Elastosis and often chronic inflammation of dermis Follicular [pathologyoutlines.com]

[…] cutaneous horn (due to excessive production of parakeratotic scale) Microscopic (histologic) description Basal cell and squamous layer atypia and disorderly maturation, hyperkeratosis [pathologyoutlines.com]

Chronic Alcoholism

Vitamin C deficiency (scurvy) results in swollen gums, follicular hyperkeratosis and corkscrew hairs. [dermnetnz.org]

Vitamin C deficiency ( scurvy ) results in swollen gums, follicular hyperkeratosis and corkscrew hairs. [dermnetnz.org]

Vitamins are essential to maintain healthy looking skin: Vitamin A deficiency results in xerosis (dry skin) and follicular hyperkeratosis (rough follicles). [dermnetnz.org]

Palmoplantar Keratosis

Other cutaneous manifestations include acanthosis nigricans, xerosis, follicular hyperkeratosis over the zygoma, and hyperhidrosis. [emedicine.com]

Drug-Induced Lupus Erythematosus

Histopathology: follicular hyperkeratosis, vacuolization of the basal layer of the epidermal and follicular epithelium, superficial perivascular mononuclear infi ltrate and [doi.org]

Perifolliculitis Capitis Abscedens

There may be some follicular hyperkeratosis around the orifice. Special stains for fungus, bacteria and mycobacteria are negative. [dermatologyadvisor.com]

hyperkeratosis. 10 The early common cause of follicular occlusion triad is follicular hyperkeratosis. [docplayer.net]

The etiology remains unclear, however the mechanism appears to be related to follicular hyperkeratosis and occlusion. [jscimedcentral.com]

Fitzsimmons-McLachlan-Gilbert Syndrome

Follicular hyperkeratosis: Also known as inverted follicular hyperkeratosis, this condition presents as a single bump, often on the face, of middle-aged or older adults. [healthline.com]

"Role of vitamin E in the aetiology of phrynoderma (follicular hyperkeratosis) and its interrelationship with B-complex vitamins". [en.wikipedia.org]

Distinctive Facial Appearance and Preaxial Polydactyly of Feet Familial Focal Alopecia Fitzsimmons-McLachlan-Gilbert syndrome Follicular Hamartoma, Alopecia, Cystic Fibrosis follicular [rgd.mcw.edu]

Demodicosis

and mild to moderate follicular hyperkeratosis ." ( J1 .29.w13) Hairs mainly in telogen and catagen. ( J1 .29.w13) Mild acanthosis on the forearms. ( J1 .29.w13) Rarely, [wildpro.twycrosszoo.org]

Demodex folliculorum is characterised histologically by: Numerous demodex mites in the infundibula of the follicles Follicular hyperkeratosis Focal follicular lichenoid lymphocytic [dermnetnz.org]

[…] superficial dermatitis and follicular pustules. ( J1 .29.w13) Presence of Demodex sp. mites within hair follicles (more than 20 in a single cross section of some follicles [wildpro.twycrosszoo.org]

Hidradenitis Suppurativa

hyperkeratosis, whereas an isotopic hyperplasia of follicular epithelium was evident in 77%. [ncbi.nlm.nih.gov]

Patients may simultaneously present with 2 or more of the diseases within the tetrad. 5 In HS, hyperplasia of the follicular epithelium causes follicular hyperkeratosis and [the-dermatologist.com]

The earliest change is plugging, which occurs in follicular hyperkeratosis with infundibulofolliculitis. [emedicine.com]

Scurvy

A 9-year-old girl had the insidious development of lethargy, gingival erosions, and follicular hyperkeratosis with perifollicular hemorrhage. [ncbi.nlm.nih.gov]

The clinical manifestations of follicular hyperkeratosis, perifollicular petechiae, corkscrew hairs, and easy bruising are due to defective collagen synthesis and can be mistaken [ncbi.nlm.nih.gov]

It classically presents as follicular hyperkeratosis and perifollicular hemorrhage of the lower extremities, as well as bleeding in other areas such as the gingiva and joints [ncbi.nlm.nih.gov]

Idiopathic Recurrent and Disabling Cutaneous Herpes

Follicular hyperkeratosis, most prominent on the nose, is considered a sign of paraneoplastic myeloma. [emedicine.medscape.com]

Papillon Lefevre Disease

Patients may also present with malodorous hyperhidrosis, follicular hyperkeratosis, nail dystrophy or dural calcifications. [rarediseases.info.nih.gov]

hyperkeratosis and keratosis on the elbows and knees. [jidonline.com]

[…] transgredient (first occurs on the palms and soles and then spreads to the dorsa of the hands and feet) palmarplantar keratosis develops, with occasional reports of diffuse follicular [jidonline.com]