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67 Possible Causes for Foot Drop, Hyperreflexia, Severe Peripheral Motor Neuropathy

  • Chronic Kidney Insufficiency

    […] filtration rate [eGFR] 15 mL/min/1.73 m 2 ), neuromuscular symptoms may be present, including coarse muscular twitches, peripheral sensory and motor neuropathies, muscle cramps, hyperreflexia[merckmanuals.com] , peripheral sensory and motor neuropathies, muscle cramps, hyperreflexia, restless legs syndrome, and seizures (usually the result of hypertensive or metabolic encephalopathy[merckmanuals.com] With more severe renal disease (eg, estimated glomerular filtration rate [eGFR] 15 mL/min/1.73 m 2 ), neuromuscular symptoms may be present, including coarse muscular twitches[merckmanuals.com]

  • Multifocal Motor Neuropathy

    Atrophy may be present, but hyperreflexia and spasticity are not seen.[ncbi.nlm.nih.gov] Clinically, it is characterized by slowly progressive asymmetrical predominantly distal weakness; unilateral wrist drop, grip weakness, and foot drop are the commonest initial[ncbi.nlm.nih.gov] An autopsy showed severe widespread demyelination without lymphoma cell infiltration in the peripheral nerves.[ncbi.nlm.nih.gov]

  • Peripheral Neuropathy

    Ferrer-Donato, Julio Gomez-Soriano, Stefano Piazza and Julian Taylor , Early treatment with UR13870, a novel inhibitor of p38α mitogenous activated protein kinase, prevents hyperreflexia[dx.doi.org] CASE REPORT: A 47-yr-old female hyperbaric technician developed foot drop 2 d following her last hyperbaric exposure.[ncbi.nlm.nih.gov] We treated a 52-year-old man who had severe disabling classic peripheral neuropathy since 1998 with Scrambler Therapy (Calmare), an FDA-cleared peripheral non-invasive neuromodulation[ncbi.nlm.nih.gov]

  • Guillain-Barré Syndrome

    In the cases with Bickerstaff brainstem encephalitis, there was associated altered consciousness and in some, hyperreflexia, in support of a central pathology whereas in Fisher[ncbi.nlm.nih.gov] Two years after the onset, the patient still suffered from residual leg weakness and foot drop.[scinapse.io] Acute Motor Axonal Neuropathy (AMAN) No sensory deficits Associated with epidemics following C. jejuni enteritis.[pedemmorsels.com]

  • Charcot-Marie-Tooth Disease

    Signs of this "serotonin syndrome" include changes in mental status, hypertension, restlessness, myoclonus (sudden muscle contraction), hyperreflexia (accentuated reflexes[web.archive.org] Abstract Gait abnormalities reported in childhood Charcot-Marie-Tooth disease (CMT) include foot-drop, reduced ankle power at push-off and increased knee and hip flexion for[ncbi.nlm.nih.gov] Charcot-Marie Tooth disease (CMT) encompasses several inherited peripheral motor-sensory neuropathies and is one of the most common inherited neuromuscular diseases.[ncbi.nlm.nih.gov]

  • Spastic Paraplegia

    This case showed spasticity and hyperreflexia with pathological reflexes and ankle clonus as well as muscle weakness in all extremities.[ncbi.nlm.nih.gov] […] orthosis) can help foot drop (read more about the treatment of foot drop ) surgery may occasionally be needed to release tendons or shortened muscles Outlook The outlook[your.md] neuropathy and evidence of lower motor involvement.[now.aapmr.org]

  • Mononeuritis Multiplex

    CNS Upper motor neuron signs (spasticity, hyperreflexia, upgoing plantar reflexes) are usually seen distal to the lesion.[cancertherapyadvisor.com] Mononeuritis multiplex is a peripheral sensorimotor neuropathy usually producing foot or wrist drop, commonly associated with necrotizing arteritis of small and medium-sized[ncbi.nlm.nih.gov] […] and motor peripheral neuropathy involving simultaneous or sequential damage to two or more noncontiguous peripheral nerves .  : Bradely’s neurology in clinical practice 7th[slideshare.net]

  • Autosomal Dominant Spastic Paraplegia Type 8

    Symptoms include hyperreflexia, extensor plantar responses, degeneration of the lateral corticospinal tracts, decreased vibratory sense in the lower limbs, pes cavus and atrophy[cags.org.ae] The disease presents with distal weakness affecting the lower limbs more than the upper limbs (e.g. peroneal muscular atrophy with flaccid foot drop).[neuroweb.us] People with this condition may also have hyperreflexia, decreased ability to feel vibrations, muscular atrophy and decreased bladder control.[ivami.com]

  • Autosomal Dominant Spastic Paraplegia Type 31

    Recessive Symptoms & Phenotypes for Spastic Paraplegia 24, Autosomal Recessive Symptoms via clinical synopsis from OMIM: 57 Neurologic Central Nervous System: spasticity hyperreflexia[malacards.org] The disease presents with distal weakness affecting the lower limbs more than the upper limbs (e.g. peroneal muscular atrophy with flaccid foot drop).[neuroweb.us] Neurologic examination revealed hyperreflexia and spasticity in the lower extremities, weakness of hip flexion and ankle dorsiflexion, extensor plantar response, diminished[neurology.org]

  • Autosomal Recessive Spastic Ataxia with Leukoencephalopathy

    Related phenotypes are hyperreflexia and cerebellar hypoplasia[malacards.org] Distal amyotrophy, which leads to loss of ankle reflexes and sometimes bilateral foot drop, is found in most individuals after age 21 years.[ncbi.nlm.nih.gov] […] axonal neuropathy Skeletal muscle atrophy Clumsiness Cerebral cortical atrophy Intellectual disability, profound Severe global developmental delay Motor deterioration Renal[mendelian.co]

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