Upper motor neuron signs (spasticity, hyperreflexia, extensor plantar response).[clinicaltrials.gov] Clinically, it is characterized by slowly progressive asymmetrical predominantly distal weakness; unilateral wrist drop, grip weakness, and foot drop are the commonest initial[ncbi.nlm.nih.gov] Usually beginning in one or both hands, MMN is characterized by weakness, muscle atrophy, cramping, and often profuse fasciculations (muscle twitching).[en.wikipedia.org]
The upper motor signs include spasticity, hyperreflexia and weakness. The lower motor signs include amyotrophy, weakness and fasciculations.[symptoma.com] twitching for 3 years.[ncbi.nlm.nih.gov] This usually begins on one side of the body and can cause loss of hand dexterity, shoulder function, a foot-drop or walking difficulty.[alsbc.ca]
The neurologic examination usually reveals symmetric weakness with either flaccidity and hyporeflexia (if the diagnosis is made early) or spasticity and hyperreflexia (if[aafp.org] […] contractions, twitches, or spasms (fasciculations) Muscle weakness (decreased muscle strength) in the legs that causes falls, makes walking difficult, and may get worse ([medlineplus.gov] […] cough or sneeze), and may extend to the hips or legs Cold sensation of the legs, cool fingers or hands, or coolness of other areas Loss of bowel control, bladder leakage Muscle[medlineplus.gov]
No spasticity or hyperreflexia.[brainscape.com] Lower motor neuron disease causes weakness, loss of muscle ("atrophy") and muscle twitching ("fasciculations").[neurology.emory.edu] However, occasionally problems in the leg or legs may occur: Foot drop (early). Gait disorder. A sensation of heaviness of one or both legs. A tendency to trip.[patient.info]
hyperreflexia ( ) Hoffman's ( ) Babinski's spastic dysarthria lower motor neuron (LMN) signs muscular atrophy weakness clinical fasciculations clumsiness Evaluation Diagnosis[orthobullets.com] However, occasionally problems in the leg or legs may occur: Foot drop (early). Gait disorder. A sensation of heaviness of one or both legs. A tendency to trip.[patient.info] Muscles twitch (called fasciculations) and waste away.[msdmanuals.com]
However, hyperreflexia and spasticity typical of ALS never occur in MMN. Conduction block Amount of block increases with more proximal stimulation. B.[neuromuscular.wustl.edu] Motor neuropathy symptoms may include: Muscle weakness Cramps Muscle twitching Loss of muscle and bone Changes in skin, hair, or nails Sensory neuropathy symptoms may include[stlouischildrens.org] Symptoms Signs Paresthesias (57% of patients) 3 Initially in fingers, followed by feet Impaired vibration sense Proprioception is spared Wrist and foot “drop” 6 Neuritic pain[pedsoncologyeducation.com]
Lower motor neuron (LMN) findings include muscle atrophy and fasciculations, and upper motor neuron (UMN) findings include hyperreflexia, spasticity, muscle spasm, and abnormal[en.wikipedia.org] A 69-year-old man with long-standing depression and failing memory presented with muscle twitches of 8 months' duration.[ncbi.nlm.nih.gov] drop, or slurred speech.[alsnewstoday.com]
CNS Upper motor neuron signs (spasticity, hyperreflexia, upgoing plantar reflexes) are usually seen distal to the lesion.[clinicaladvisor.com] The muscle twitches have spread to other areas in my arms and legs, and are annoying more than anything else.[medhelp.org] Mononeuritis multiplex is a peripheral sensorimotor neuropathy usually producing foot or wrist drop, commonly associated with necrotizing arteritis of small and medium-sized[ncbi.nlm.nih.gov]
Clinical Loss of fine motor skills, triad of atrophic weakness of hands and forearms; leg spasticity; generalised hyperreflexia. Management Possibly riluzole.[medical-dictionary.thefreedictionary.com] Adult onset MND usually starts insidiously with symptoms and signs including stumbling, foot drop, weakened grip, slurred speech, cramp, muscle wasting, twitching and tiredness[nice.org.uk] This then leads to fasciculations (muscle twitches), progressively worsening muscle weakness, and a loss of muscle mass and weight.[mndcentre.org.uk]
hyperreflexia ( ) Hoffman's ( ) Babinski's spastic dysarthria lower motor neuron (LMN) signs muscular atrophy weakness clinical fasciculations clumsiness Evaluation Diagnosis[orthobullets.com] . [1] [2] There are various types of ALS that are distinguished by symptoms and, in some cases, genetic cause. [2] Early symptoms may include muscle twitching, cramping, stiffness[rarediseases.info.nih.gov] However, occasionally problems in the leg or legs may occur: Foot drop (early). Gait disorder. A sensation of heaviness of one or both legs. A tendency to trip.[patient.info]