Foot Drop & Severe Peripheral Motor Neuropathy: Causes & Reasons

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Patient File

Sex unknown, Age unknown

Reported Symptoms

Foot Drop, Severe Peripheral Motor Neuropathy,

Negated

None

Unsure

None

Possible Causes

Peripheral Neuropathy

CASE REPORT: A 47-yr-old female hyperbaric technician developed foot drop 2 d following her last hyperbaric exposure. [ncbi.nlm.nih.gov]

We treated a 52-year-old man who had severe disabling classic peripheral neuropathy since 1998 with Scrambler Therapy (Calmare), an FDA-cleared peripheral non-invasive neuromodulation [ncbi.nlm.nih.gov]

This leads to a condition called "foot drop," in which it becomes difficult to lift the foot. [webmd.com]

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Chronic Kidney Insufficiency

The restless legs syndrome is a manifestation of sensory peripheral neuropathy. Motor neuropathy is a late phenomenon in uremia. [meddean.luc.edu]

peripheral sensory and motor neuropathies, muscle cramps, hyperreflexia, restless legs syndrome, and seizures (usually the result of hypertensive or metabolic encephalopathy [merckmanuals.com]

With more severe renal disease (eg, estimated glomerular filtration rate [eGFR] 15 mL/min/1.73 m2), neuromuscular symptoms may be present, including coarse muscular twitches [msdmanuals.com]

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Multifocal Motor Neuropathy

Clinically, it is characterized by slowly progressive asymmetrical predominantly distal weakness; unilateral wrist drop, grip weakness, and foot drop are the commonest initial [ncbi.nlm.nih.gov]

[…] types of peripheral neuropathy (sensory, motor, autonomic, and mixed) occurring with diabetes mellitus; the most common is a chronic, symmetrical sensory polyneuropathy affecting [dobeti.me.ht]

Wrist drop and foot drop (leading to trips and falls) are common symptoms. Other effects can include gradual loss of finger extension, leading to a clawlike appearance. [en.wikipedia.org]

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Charcot-Marie-Tooth Disease

Abstract Gait abnormalities reported in childhood Charcot-Marie-Tooth disease (CMT) include foot-drop, reduced ankle power at push-off and increased knee and hip flexion for [ncbi.nlm.nih.gov]

Charcot-Marie Tooth disease (CMT) encompasses several inherited peripheral motor-sensory neuropathies and is one of the most common inherited neuromuscular diseases. [ncbi.nlm.nih.gov]

STATE OF THE ART REVIEW First Online: 09 February 2007 Abstract Charcot-Marie Tooth disease (CMT) encompasses several inherited peripheral motor-sensory neuropathies and is [doi.org]

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Peroneal Nerve Compression Neuropathy

Abstract Foot drop is a debilitating condition, which may take many months to recover. [omcr.oxfordjournals.org]

Diagnosis of PPNI A thorough history and clinical examination are essential to localize the lesion and to identify a pre-existing peripheral neuropathy. [academic.oup.com]

Injury to the peroneal nerve can cause foot drop, a distinctive way of walking due to an inability to bend the foot upward at the ankle. [hopkinsmedicine.org]

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Alcoholic Neuropathy

Foot braces may also be helpful if you have problems with foot drop. If you have weakness in your arms, a wrist splint may be helpful. [patient.info]

Rarely if the neuropathy is severe patients may also develop peripheral weakness (motor symptoms). [braindiseases.info]

Traumas, such as from motor vehicle accidents, falls or sports injuries, can sever or damage peripheral nerves. [mayoclinic.org]

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Guillain-Barré Syndrome

These include: Orthotis to prevent foot drop and aid walking Insoles to improve alignment, proprioception and gait Night and day resting splints to maintain alignment and [hobbsrehabilitation.co.uk]

Acute Motor Axonal Neuropathy (AMAN) No sensory deficits Associated with epidemics following C. jejuni enteritis. [pedemmorsels.com]

Two years after the onset, the patient still suffered from residual leg weakness and foot drop. [scinapse.io]

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Neuropathy

If severely affected, the patient may develop chronic muscle wasting. How is Peripheral Neuropathies Treated? [healthengine.com.au]

Injury to the common peroneal nerve results in foot drop and inversion (turning inward) of the foot. [vermontspineworks.com]

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Mononeuritis Multiplex

Mononeuritis multiplex is a peripheral sensorimotor neuropathy usually producing foot or wrist drop, commonly associated with necrotizing arteritis of small and medium-sized [ncbi.nlm.nih.gov]

[…] and motor peripheral neuropathy involving simultaneous or sequential damage to two or more noncontiguous peripheral nerves.  : Bradely’s neurology in clinical practice 7th [slideshare.net]

drop. [ncbi.nlm.nih.gov]

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Familial Progressive Polyneuropathy

Foot drop (foot can't be picked up or held horizontal) Progressive deformity of leg ("inverted champagne bottle") or foot (abnormally high arched feet, flat feet, hammer toes [peripheralneuropathycenter.uchicago.edu]

Its severity was proportional to both sensory-motor peripheral neuropathy and dysautonomia. [content.iospress.com]

Patients can also suffer from high arched feet, hammer toes, foot drop, foot deformities, and scoliosis. [en.wikipedia.org]

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Diabetic Mononeuropathy

Distribution: Common areas effected Wrist Drop ( Radial Nerve ) Loss of finger flexion and grip ( Median Nerve ) Foot drop (deep peroneal nerve, L4-L5) Recurrent laryngeal [fpnotebook.com]

Autopsy studies on several patients showed peripheral nerve degeneration ( Leyden 1887 ; Auche 1890 ). [medlink.com]

[…] care Glucose control Pain control Single nerve damage due to compression or ischemia Occurs in wrist (carpal tunnel syndrome), elbow, or foot (unilateral foot drop) Symptoms [quizlet.com]

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Lumbar Spinal Stenosis

Some patients will have a foot-drop, or the feeling that their foot slaps the ground while walking. [gwhospital.com]

The identification of motor neuron disease and peripheral neuropathies was essential. [ncbi.nlm.nih.gov]

Some patients will have a foot-drop, or the feeling that their foot slaps on the ground while walking. Less pain with leaning forward or sitting. [bmc.org]

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Hereditary Motor and Sensory Neuropathy

There can be high arched feet, hammer toes, foot drop, and foot deformities, and possibly scoliosis. Who gets Hereditary Motor Sensory Neuropathy? [aanem.org]

Abstract Hereditary motor and sensory neuropathies (HMSN) are genetically heterogeneous disorders affecting peripheral motor and sensory functions. [ncbi.nlm.nih.gov]

[…] dorsiflexor weakness Foot drop 0009027 Frequent falls 0002359 Hammertoe Hammer toe Hammertoes [ more ] 0001765 Hypertonia 0001276 Limb muscle weakness Limb weakness 0003690 [rarediseases.info.nih.gov]

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Peripheral Motor Neuropathy

Our first case was a 49-year-old male who presented with weakness in the left lower limb and foot drop of 10 days duration. [ijdvl.com]

peripheral neuropathy primarily affecting motor neurons. [ncbi.nlm.nih.gov]

[…] units in the distal muscles Risk Factors: Incidence and severity of symptoms is related to the cumulative dose: Peripheral neuropathy in vincristine treatment is seen when [pedsoncologyeducation.com]

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Charcot-Marie-Tooth Disease Type 2S

(high arch) Type 2 – Neuronal Usually less disabled than Type 1 Onset in second decade of life or later Most commonly leads to foot drop Patients will present with foot pain [paleyinstitute.org]

[from Gene Reviews, 2015.12.15] Charcot-Marie-Tooth disease (CMT) constitutes a clinically and genetically heterogeneous group of hereditary motor and sensory peripheral neuropathies [flybase.org]

Most people with CMT develop muscle atrophy and weakness in the arms and legs, foot drop, difficulties using the upper limbs, loss of sensation, and varying degrees of walking [hnf-cure.org]

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Polyneuropathy

After the inflammatory reaction gradually improved, we observed bilateral weakness of the extremities and foot drop. [ncbi.nlm.nih.gov]

Peripheral sensori-motor neuropathy  Distal, bilateral,symmetrical, stocking-glove distribution.  Symptoms range from numbness (“deadness”) to severe pain. [slideshare.net]

Patients who have foot drop due to weakness in their ankles may benefit from orthotics. Thank you for your interest in the Johns Hopkins Peripheral Nerve Center. [hopkinsmedicine.org]

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Hereditary Areflexic Dystasia

drop; foot drop can lead to inadvertent hurting of feet Severely reduced mobility Participation in sports and athletic activities may become limited How is Roussy-Lévy Syndrome [dovemed.com]

It includes several variants: Acute inflammatory demyelinative polyneuropathy (AIDP), acute motor axonal neuropathy (AMAN), and the Miller-Fisher syndrome (MFS). [neuropathology-web.org]

[…] deformity.These symptoms frequently translate into delayed onset of ability to walk, loss of coordination and balance, foot drop, and foot-bone deformities. [en.wikipedia.org]

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Distal Spinal Muscular Atrophy Type 5

Foot drop (steppage) pattern may progress to waddling gait in more advanced disease. [now.aapmr.org]

The Charcot foot has been documented to occur as a consequence of various peripheral neuropathies; however, diabetic neuropathy has become the most common etiology. [care.diabetesjournals.org]

Chronic forms CIDP Acquired demyelinating neuropathy reaching maximal severity in at least 8 weeks.: MMN Peripheral neuropathy with slowly progressive or remitting asymmetric [neupsykey.com]

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Distal Hereditary Motor Neuropathy Type 5A

The supportive treatment for HNPP can include transient bracing (e.g., a wrist splint or ankle-foot orthosis) which may become permanent in some cases of foot drop. [bcbst.com]

Charcot-Marie-Tooth disease is closely related to several less common peripheral neuropathies: distal hereditary motor neuropathy (dHMN), hereditary sensory neuropathy (HSN [tidsskriftet.no]

It results in severe demyelination with delayed motor skills and is much more severe than type 1. [patient.info]

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Diabetic Pseudotabes

It may lead to foot drop because of ankle weakness. [medical-dictionary.thefreedictionary.com]

[…] polyneuropathy Type II - axonal type - less severe, atrophy, peripheral polyneuropathy( MOST COMMON TYPE OF HERITDARY NEUROPATHY!! [quizlet.com]

[…] muscle - extensors and flexors of toes, weakness, atrophy and foot drop, foot deformities due to motor neuropathy Diabetic Peripheral Neuropathy - 9 Once established, stays [slideserve.com]

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Déjerine-Sottas Disease

Drop 386 Case 61 An Elderly Woman with Foot Drop and Hand Weakness 393 Case 62 A Woman with Rheumatoid Arthritis Who Developed Numbness and Pain in the Feet 399 Case 63 A [books.google.com]

Dejerine-Sottas neuropathy is a demyelinating peripheral neuropathy with onset in infancy. It can show autosomal dominant or recessive inheritance. [ncbi.nlm.nih.gov]

Orthotic devices are widely used - eg, plantars (correcting foot position), ankle-foot orthoses (to overcome foot drop and facilitate walking - custom fitting may be required [patient.info]

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Distal Hereditary Motor Neuropathy Type 1

The supportive treatment for HNPP can include transient bracing (e.g., a wrist splint or ankle-foot orthosis) which may become permanent in some cases of foot drop. [bcbst.com]

Charcot-Marie-Tooth disease is closely related to several less common peripheral neuropathies: distal hereditary motor neuropathy (dHMN), hereditary sensory neuropathy (HSN [tidsskriftet.no]

It results in severe demyelination with delayed motor skills and is much more severe than type 1. [patient.info]

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Diabetic Enteropathy

[…] care Glucose control Pain control Single nerve damage due to compression or ischemia Occurs in wrist (carpal tunnel syndrome), elbow, or foot (unilateral foot drop) Symptoms [quizlet.com]

Peripheral sensori-motor neuropathy  Distal, bilateral,symmetrical, stocking-glove distribution.  Symptoms range from numbness (“deadness”) to severe pain. [slideshare.net]

Manassero made the turn in 36 but then came to life on the front-nine with birdies on the first, third, fourth and sixth before a ten-foot putt on the seventh briefly gave [khbpoint.blogspot.com]

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Neuromuscular Junction Disorder

Presents with foot drop and involvement of the scapular muscles. 3.1.3 Autosomal Recessive. This accounts for most of the sporadic cases seen. [academic.sun.ac.za]

Diseases of the peripheral nerves (peripheral neuropathies, or polyneuropathies ) can produce symptoms similar to the motor neuron diseases. [britannica.com]

Foot drop or lateral hand weakness and atrophy are the initial common presentations. [lecturio.com]

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Diabetic Amyotrophy

Design/Methods: A 62 year old with history of diabetes mellitus-II presented with 2 weeks history of right foot drop and back pain radiating down into right lateral thigh, [n.neurology.org]

It includes several variants: Acute inflammatory demyelinative polyneuropathy (AIDP), acute motor axonal neuropathy (AMAN), and the Miller-Fisher syndrome (MFS). [neuropathology-web.org]

Aside from pain patient may present with foot drop due to weakness of leg muscles. Due to weakness in the leg, person is unable to balance himself and walk properly. [tandurust.com]

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Proximal Myopathy with Extrapyramidal Signs

Alternatively, foot drop may be an early manifestation. [neuroweb.us]

Motor nerve conduction studies may demonstrate a peripheral neuropathy in some cases. Most patients show excellent response to phenytoin or carbamazepine. [intranet.tdmu.edu.ua]

Trendelenburg gait is also seen in L5 radiculopathy and after poliomyelitis, in which case there is usually also a foot drop. [patient.info]

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Paraneoplastic Syndrome

After tumor resection, synovitis resolved and foot-drop disappeared almost totally. [ncbi.nlm.nih.gov]

More than half of the patients with the rare osteosclerotic form of myeloma develop a severe predominantly motor paraneoplastic peripheral neuropathy. [theoncologist.onlinelibrary.wiley.com]

Monoarthritis and foot-drop was resistant to non-steroidal anti-inflammatory drugs and corticosteroids. [ncbi.nlm.nih.gov]

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Drug-induced Peripheral Neuropathy

drop have been noted with high doses. 8,9 Platinum Compounds: Cisplatin (Platinol ) Carboplatin (Paraplatin ) Oxaliplatin (Eloxatin ) Not listed 4% 10 74% 11 Mild to moderate [cancersupportivecare.com]

[…] symptoms limiting self-care ADL Grade 4: Life-threatening consequences; urgent intervention indicated Grade 5: Death Peripheral Motor Neuropathy Grade 1: Asymptomatic clinical [hematology.org]

Distal motor weakness potentially leading to foot drop, gait abnormalities, hand weakness, and muscle atrophy. (e.g. [now.aapmr.org]

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Distal Spinal Muscular Atrophy Type 4

The leg weakness frequently causes “foot drop” and a waddling gait. [britannica.com]

Several subtypes of inherited peripheral neuropathies were delineated and classified as hereditary motor and sensory neuropathies (HMSN), hereditary motor neuropathies (HMN [molgen.ua.ac.be]

The disease presents with distal weakness affecting the lower limbs more than the upper limbs (e.g. peroneal muscular atrophy with flaccid foot drop). [neuroweb.us]

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CANOMAD Syndrome

A few however are unable to go back to their former occupation because of residual disabilities, for example, hand weakness, foot drop or the need for walking aids. [gbsnz.org.nz]

Interpretation: Anti-glycolipid antibodies are associated with several distinct peripheral nerve syndromes: Multifocal motor neuropathy is associated with anti-GM1, -GA1 and [southtees.nhs.uk]

The disease presents with distal weakness affecting the lower limbs more than the upper limbs (e.g. peroneal muscular atrophy with flaccid foot drop). [neuroweb.us]

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