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354 Possible Causes for Foot Pain, Hypomyelination

  • Peripheral Neuropathy

    Magnetic resonance imaging showed cortical disturbances in addition to profound hypomyelination and cerebellar atrophy.[ncbi.nlm.nih.gov] […] the numbness and pain from nerve damage that often affects hands and feet. — Tara Bahrampour, The Seattle Times, "Loud banging, foot pain, flashes of light: a reporter’s[merriam-webster.com] […] asymmetric demyelinating-type peripheral neuropathy, and sural nerve biopsy documented reduced myelinated nerve fiber density with uniformly thin myelin sheaths, suggesting hypomyelination[ncbi.nlm.nih.gov]

  • Arthritis

    Stowe and Lakshmi Raman, Perinatal chronic hypoxia induces cortical inflammation, hypomyelination, and peripheral myelin‐specific T cell autoreactivity, Journal of Leukocyte[doi.org] Results: The key themes derived from the podiatry clinician focus groups suggest a variety of factors influencing demand for, and burden of, foot pain within the UK.[ncbi.nlm.nih.gov] Foot pain.[mayoclinic.com]

  • Déjerine-Sottas Disease

    , consistent with congenital hypomyelination neuropathy (CHN).[ncbi.nlm.nih.gov] […] dĕ-zhĕ-rēn' sō-tahz' ), a familial type of demyelinating sensorimotor polyneuropathy that begins in early childhood and is slowly progressive; clinically characterized by foot[medical-dictionary.thefreedictionary.com] They include Charcot-Marie-Tooth disease, Dejerine-Sottas disease, congenital hypomyelinating neuropathy and hereditary neuropathy with liability to pressure palsy.[ncbi.nlm.nih.gov]

  • Hereditary Motor and Sensory Neuropathy

    A – D, MR images of the lumbosacral spine in a patient with the congenital hypomyelinating form of DSD (case 8).[ajnr.org] Custom-made foot orthoses for the treatment of foot pain, Cochrane Database of Systematic Reviews(3), 2008. Leeuwesteijn, AE et. al.[now.aapmr.org] In other types of congenital hypomyelination neuropathy, clinical manifestations are variable.[healio.com]

  • Young Adult-Onset Distal Hereditary Motor Neuropathy

    GJC2 Leukodystrophy hypomyelinating type 3 AIMP1 Leukodystrophy hypomyelinating type 4 HSPD1 Leukodystrophy hypomyelinating type 5 FAM126A Leukodystrophy hypomyelinating[centogene.com] Custom-made foot orthoses for the treatment of foot pain, Cochrane Database of Systematic Reviews(3), 2008. Leeuwesteijn, AE et. al.[now.aapmr.org] CMT4E, also known as congenital hypomyelination neuropathy, is caused by an abnormality in the EGR2 gene located on chromosome 10 at 10q21.1-q22.1.[rarediseases.org]

  • Charcot-Marie-Tooth Disease Type 2S

    […] or Amyelinating, Autosomal Recessive Charcot-Marie-Tooth Disease, Type 4e Charcot-Marie-Tooth Neuropathy, Type 4e Congenital Hypomyelinating Neuropathy Hypomyelination, Severe[ukgtn.nhs.uk] (high arch) Type 2 – Neuronal Usually less disabled than Type 1 Onset in second decade of life or later Most commonly leads to foot drop Patients will present with foot pain[paleyinstitute.org] pain.[orthobullets.com]

  • Distal Hereditary Motor Neuropathy Type 1

    […] neuropathy (with hypotonia at birth) and congenital hypomyelination neuropathy, life expectancy may be only a few months Essential features Atrophic myofibers with myofiber[pathologyoutlines.com] pain.[orthobullets.com] DI-CMTB AD 19p12–p13.2 DYN2 DI-CMTC AD 1p34–p35 YARS RI-CMT AR 1p36.31 PLEKHG5 CMT3 (Dejerine–Sottas disease, congenital hypomyelinating neuropathy) AD 17p11.2 PMP22 AD 1q21[mhmedical.com]

  • Hereditary Areflexic Dystasia

    In contrast to the findings in younger patients, in their nerve biopsies, myelin thickness tended to be relatively reduced for axon size, indicating remyelination and/or hypomyelination[doi.org] During walking, these deformities can cause unusual friction against the toes, heel and ball of the foot, leading to painful abrasions, blisters and calluses.[mda.org] […] can also cause other forms of CMT (Charcot-Marie-Tooth type 1 and 2, Dejerine–Sottas neuropathy, hereditary neuropathy with liability to pressure palsies, and congenital hypomyelinating[rarediseases.info.nih.gov]

  • Demyelinating Disease

    DVM, DACVIM, Professor and Hospital Director, Center for Veterinary Health Sciences, Oklahoma State University Demyelinating Disorders Overview of Demyelinating Disorders Hypomyelination[msdvetmanual.com] […] within 1 day extended to the contralateral foot and was associated with mid-thoracic back pain.[jnnp.bmj.com] DeBoy, Pharmacological approaches to intervention in hypomyelinating and demyelinating white matter pathology, Neuropharmacology, 10.1016/j.neuropharm.2015.06.008, 110, (605[doi.org]

  • Cerebro-Oculo-Facio-Skeletal Syndrome

    This cell death and malfunctioning likely contributes to the symptoms of Cockayne Syndrome such as premature aging and hypomyelination of neurons. [7] DNA repair [ edit ][en.wikipedia.org] Congenital ischemic atrophy of central nervous system structure Congenital spastic foot Developmental displacement of brachial plexus Disorder of neuronal migration and differentiation[icdlist.com] However, hypomyelination and the facial features of typical CS patients are not present. [15] Treatment [ edit ] There is no permanent cure for this syndrome, although patients[en.wikipedia.org]

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