Foot Process Effacement: Causes & Reasons

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Possible Causes for Foot Process Effacement

Nephrotic Syndrome Type 8

NS is associated with the biopsy finding of effacement of podocyte foot processes. [frontiersin.org]

In seven of the nine patients, electron microscopy revealed diffuse foot process effacement. [omicsonline.org]

process effacement. [f1000research.com]

Acute Interstitial Nephritis

Acute interstitial nephritis and podocyte foot-process effacement might be under-recognized lesions in MARF. [ncbi.nlm.nih.gov]

Her renal failure soon recovered, and renal biopsy showed acute interstitial nephritis by light microscopy with glomerular foot process effacement by electron microscopy. [ncbi.nlm.nih.gov]

foot processes with no deposits. [ncbi.nlm.nih.gov]

Minimal Change Nephropathy

Podocyte foot process effacement Comment Here Back to top [pathologyoutlines.com]

foot processes podocytes swell up & foot processes effaced. [slideshare.net]

minimal change disease (lipoid nephrosis) LM: normal glomeruli; EM foot process effacement -?- focual segmental glomerular sclerosis more severe in HIV patients -? [ome.umaryland.edu]

Focal Segmental Glomerulosclerosis

PathOut servers: Foot process effacement in collapsing FSGS #1; #2 in tip variant of FSGS Cellular variant General : Compared to classic focal segmental glomerulosclerosis [pathologyoutlines.com]

There was effacement of approximately half of the epithelial cell foot processes on electron microscopy. [karger.com]

We show that circulating suPAR activates podocyte β(3) integrin in both native and grafted kidneys, causing foot process effacement, proteinuria and FSGS-like glomerulopathy [ncbi.nlm.nih.gov]

Renal Glomerular Disease

Podocyte foot process effacement. [niddk.nih.gov]

What disease is diagnosed by podocyte foot process effacement (fusion) on EM and normal appearing glomeruli, interstitium, and tubules on LM? [cram.com]

process effacement, see figure secondary causes: cancer, infection, drugs, atopy (hyperallergic) Associated with lymphoma and use of NSAIDs Primary glomerular disease with [youtube.com]

Idiopathic Membranous Glomerulonephritis

process effacement persisted during the course of the disease. [ncbi.nlm.nih.gov]

A marked loss of the negative charge on the epithelial cell surface coat (ESC) covering the deposits and foot process effacement were persisted during the course of the disease [jstage.jst.go.jp]

[…] deposits, diffuse foot process effacement Stage III : LM - markedly thickened GBM, residual spikes and vacuoles, chain like appearance; IF - coarsely granular IgG, C3; EM [pathologyoutlines.com]

Glomerulosclerosis

Diffuse foot process fusion occurs, predominantly in the sclerotic segments, although partial effacement may be observed in normal-appearing lobules. [emedicine.medscape.com]

Electron micrograph showing extensive foot process effacement (arrowheads) in MCD. Spiral arrows point to microvillous transformation of podocytes. Figure 2. [renalandurologynews.com]

AIDS-Associated Nephropathy

Electron microscopy reveals wrinkling of the basement membranes, epithelial cell proliferation, and foot process effacement. [kidneypathology.com]

Electron microscopy reveals wrinkling of the basement membranes, epithelial cell proliferation, and focal foot process effacement. [emedicine.com]

Electron microscopy showing a segment of the glomerular basement membrane; foot process effacement (black arrow) and prominent tubuloreticular inclusions (red arrow) are present [emedicine.com]

Focal Embolic Glomerulonephritis

( FSGS ) : damage to the podocytes Electron microscopy : effacement of the foot processes Immunofluorescent microscopy: IgM and C3 inside sclerotic lesions Light microscopy [amboss.com]

Focal effacement of podocyte foot processes was noted. Histological diagnosis: immune complex-mediated necrotizing and crescentic glomerulonephritis. [revistanefrologia.com]

Fibronectin Glomerulopathy

Various degrees of foot process effacement is usually seen. No specific treatment has been described. [indianjnephrol.org]

Transmission electron microscopy (EM) on six glomeruli showed extensive foot process effacement, associated with irregular width of the GBM. [academic.oup.com]

GBM thickening and foot process effacement is visible by electron microscopy, which should also exclude the presence of immune electron-dense deposits or fibrils 5-8. [scielo.mec.pt]

Nephrotic Syndrome

Kidney biopsy revealed tubular cell damage, epithelial cell damage in glomeruli and diffuse foot process effacement in electron microscopy. [ncbi.nlm.nih.gov]

Biopsy showed diffuse foot-process effacement consistent with minimal change disease and findings of acute tubular injury. [ncbi.nlm.nih.gov]

Kidney biopsy showed diffuse loss of podocyte cytoarchitecture, extensive foot-process effacement, and glomerular endothelial injury. [ncbi.nlm.nih.gov]

Nodular Glomerulosclerosis

Histopathologically, all specimens showed varying degrees of nodular glomerulosclerosis, glomerular basement membrane thickening, foot process effacement, interstitial fibrosis [ncbi.nlm.nih.gov]

SEM showing preserved areas (small arrow) and areas (large arrow) of foot process effacement (H) (12000x). [scielo.br]

In seven of the nine patients, electron microscopy revealed diffuse foot process effacement. [omicsonline.org]

C1Q Nephropathy

Degree of podocyte foot process effacement in 23 C1q nephropathy patients with NS and no lesions or FSGS by light microscopy a Parameter Podocyte Foot Process Effacement [ncbi.nlm.nih.gov]

process effacement on electron microscopy. [link.springer.com]

Note also extensive foot process effacement and segmental podocyte-free surface microvillous transformation. [ncbi.nlm.nih.gov]

Immunotactoid Glomerulopathy

These deposits permeate the glomerular basement membrane; there is complete overlying effacement of foot processes on the left 27. [slideshare.net]

Galloway-Mowat Syndrome

Lin et al. claimed that although there is no specific electron microscopic lesion in GMS, foot process effacement along with irregular thickening of the basement membrane [hindawi.com]

Electron microscopy showed an irregular glomerular basement membrane and effacement of foot processes. [link.springer.com]

[…] of foot processes [14]. [ojrd.biomedcentral.com]

Benign Arteriolar Nephrosclerosis

process effacement. 4 Haematuria and(or) proteinuria presenting during the first 6 months course, the HSP should be diagnosed. 5 The major clinical manifestation are proteinuria [sentencedict.com]

There is extensive foot process effacement in this segment (arrowheads; scale bar = 2 µm). [file.scirp.org]

Fig 43 Minimal Change Disease (Lipoid Nephrosis) Visceral epithelial cells show uniform and diffuse effacement of foot process Thin BN. [slideplayer.com]

Immunoglobulin-Mediated Membranoproliferative Gomerulonephritis

Ultrastructural studies showed typical deposits in the lamina densa of GBM characterized by a very electron-dense appearance and foot process effacement in some glomerular [sjkdt.org]

The glomeruli appear normal by LM and IF but diffuse effacement of the podocyte foot processes is observed on EM. [gainesville.com]

( FSGS ) : damage to the podocytes Electron microscopy : effacement of the foot processes Immunofluorescent microscopy: IgM and C3 inside sclerotic lesions Light microscopy [amboss.com]

Post-Infectious Glomerulonephritis

Extensive and widespread podocyte foot process effacement. [path.upmc.edu]

process effacement Kriz Wilhelm; Shirato Isao; Nagata Michio; LeHir Michel; ... [trios.tsukuba.ac.jp]

Podocyte foot process effacement is recognized to occur in a subset of patients with IgA glomerular disorders and HIV disease, in addition to minimal change disease. [path.upmc.edu]

Nephrotic Syndrome Type 2

NS is associated with the biopsy finding of effacement of podocyte foot processes. [frontiersin.org]

process effacement. [f1000research.com]

Nephrotic syndrome is associated with the biopsy finding of fusion (effacement) of podocyte foot processes. [emedicine.medscape.com]

Galloway-Mowat Syndrome Type 2

Lin et al. claimed that although there is no specific electron microscopic lesion in GMS, foot process effacement along with irregular thickening of the basement membrane [hindawi.com]

process effacement of markedly hypertrophied and swollen podocytes with electron-lucent transport vesicles, increased organelles, and a disrupted actin cytoskeleton (Figures [hindawi.com]

[…] sections stained with lead citrate and uranyl acetate revealed wrinkling, irregular thinning, and thickening of the glomerular basement membranes, accompanied by diffuse foot [hindawi.com]

Nephrotic Syndrome Type 1

NS is associated with the biopsy finding of effacement of podocyte foot processes. [frontiersin.org]

of foot processes Electron microscopy images Images hosted on other servers: Wide effacement of epithelial foot processes Back to top [pathologyoutlines.com]

(In the nephrotic syndrome, there is effacement of the foot process, but the rest of the cell usually is preserved.) [pedsinreview.aappublications.org]

Platelet-Type Bleeding Disorder 19

Electron microscopy commonly reveals glomerular basement membrane thickening and podocyte foot process effacement 1. [ncbi.nlm.nih.gov]

NMMHC-IIA is an important component of podocyte foot process. [ncbi.nlm.nih.gov]

Nephrotic Syndrome Type 9

NS is associated with the biopsy finding of effacement of podocyte foot processes. [frontiersin.org]

In seven of the nine patients, electron microscopy revealed diffuse foot process effacement. [omicsonline.org]

process effacement. [f1000research.com]

Membranous Glomerulonephritis

Renal biopsy demonstrated extensive foot process effacement as well as confluent small subepithelial electron-dense deposits, which is diagnostic of membranous glomerulonephritis [ncbi.nlm.nih.gov]

Diffuse foot process fusion occurs, predominantly in the sclerotic segments, although partial effacement may be observed in normal-appearing lobules. [emedicine.medscape.com]

There was extensive effacement of the foot processes of the visceral epithelial cells. [cjasn.asnjournals.org]

Frasier Syndrome

A renal biopsy at the age of seven years showed segmentally effaced podocyte foot processes with no evidence of glomerulosclerosis. [ncbi.nlm.nih.gov]

NS is associated with the biopsy finding of effacement of podocyte foot processes. [frontiersin.org]

There is also irregular effacement of foot processes with focal detachment of the epithelial cell from the glomerular basement membrane. [nephronpower.com]

Nephropathic Cystinosis

The presence of hypertrophic multinucleated podocytes with foot process effacement is pathognomonic of NC, but can only be determined by means of electron microscopy. [symptoma.com]

[…] of foot processes Back to top [pathologyoutlines.com]

Using electron microscopy, podocytes appear hypertrophic, multinucleate and have foot process effacement which is pathognomonic for cystinosis (23). [ncbi.nlm.nih.gov]

Nail-Patella Syndrome

Besides podocyte foot-process effacement, pathognomonic changes in the kidney comprise electron-lucent areas and fibrillar inclusions in the glomerular basement membrane. [ncbi.nlm.nih.gov]

With the electron microscope, we can see the podocyte foot process effacement, glomerular basement membrane thickening with areas of rarefaction and dispersed collagen fibril [revistanefrologia.com]

Proliferative Glomerulonephritis

Widespread foot process effacement was seen, which explained massive proteinuria in this patient. [bmcnephrol.biomedcentral.com]

EM showed extensive (> 80%) podocyte foot process effacement and segmental duplication of glomerular basement membranes. [karger.com]

On electron microscopy, the classic finding is flattening, effacement, and fusion of the foot processes.80 Podocyte injury leads to a decrease in production of negatively [what-when-how.com]

Bilateral Renal Hypoplasia

Progressive changes(1) Foot process effacement;(2) Podocyte apoptosis/loss and exposed glomerular basement membrane;(3) Filtration of non-specific plasma proteins;(4) Capillary [slideshare.net]

[…] of podocyte foot processes Increased permeability of the glomerular capillary wall Massive proteinuria Hypoalbuminaemia Edema 12 Clinical Features 13 Edema – Mild to start [slideplayer.com]

Histo-Pathology• Podocyte foot process effacement is considered the pathognomonic feature of the early stage of recurrence of FSGS• Podocyte detachment from the GBM and loss [slideshare.net]

Drug-Induced Hypokalemia

Half the epithelial foot processes were effaced, and there were no pathological findings in the mitochondria. [bmcnephrol.biomedcentral.com]

Electron microscopy showed epithelial foot process effacement and electron-dense deposits in the subendothelial and mesangial spaces. [bmcnephrol.biomedcentral.com]