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34 Possible Causes for Fragmented Mitochondrial Network

  • Pseudomonas Aeruginosa

    In contrast, exposure to P. aeruginosa in liquid induced dramatic mitochondrial disruption in C. elegans, fragmenting the network and reducing it to large, punctate bodies[doi.org] Adding phenanthroline or partially purified pyoverdin to an otherwise benign E. coli strain also caused mitochondrial fragmentation ( Fig. 2 A and Fig. S1 A ).[doi.org]

  • Parkinson's Disease

    DNA damage, decreased ATP synthesis rates and increased fragmentation of the mitochondrial network, all suggesting an effect of mitochondrial quality control.[doi.org] Crossref] , [PubMed] , [Web of Science ] , [Google Scholar] Studies on fibroblasts from these patients demonstrated that, as compared to controls, there are high rates of mitochondrial[dx.doi.org] [Crossref], [PubMed], [Web of Science ], [Google Scholar] Studies on fibroblasts from these patients demonstrated that, as compared to controls, there are high rates of mitochondrial[doi.org]

  • Autosomal Dominant Optic Atrophy and Cataract

    […] target sequence results in altered steady-state levels and fragmented mitochondrial network.[link.springer.com] Downregulation of OPA1 leads to fragmentation of the mitochondrial network and dissipation of the mitochondrial membrane potential with cytochrome c release and caspase-dependent[ncbi.nlm.nih.gov] Delettre C, Delprat B, Oexle K, Leo-Kottler B, Roscioli T, Krüger R, Rapaport D, Wissinger B, Schimpf-Linzenbold S (2013) A novel heterozygous OPA3 mutation located in the mitochondrial[link.springer.com]

  • Spastic Paraplegia

    We further show that overexpression of the mutant ATAD3A fragments the mitochondrial network and induces lysosome mass.[ncbi.nlm.nih.gov]

  • Optic Atrophy

    Impaired YME1L1 function causes a proliferation defect and mitochondrial network fragmentation due to abnormal processing of OPA1.[ncbi.nlm.nih.gov] The homozygous missense mutation, located in a highly conserved region in the mitochondrial pre-sequence, inhibits cleavage of YME1L1 by the mitochondrial processing peptidase[ncbi.nlm.nih.gov] Our results identify mutations in YME1L1 as a cause of a mitochondriopathy with optic nerve atrophy highlighting the importance of YME1L1 for mitochondrial functionality in[ncbi.nlm.nih.gov]

  • Myopathy

    In patient fibroblasts, MSTO1 mRNA and protein abundance are decreased, mitochondria display fragmentation, aggregation, and decreased network continuity and fusion activity[ncbi.nlm.nih.gov] Lactate stress test and myopathological results suggest mitochondrial dysfunction.[ncbi.nlm.nih.gov] Short-term silencing of MSTO1 in HeLa cells reproduced the impairment of mitochondrial morphology and dynamics observed in the fibroblasts without damaging bioenergetics.[ncbi.nlm.nih.gov]

  • Ataxia

    In patient fibroblasts, MSTO1 mRNA and protein abundance are decreased, mitochondria display fragmentation, aggregation, and decreased network continuity and fusion activity[ncbi.nlm.nih.gov] Lactate stress test and myopathological results suggest mitochondrial dysfunction.[ncbi.nlm.nih.gov] Short-term silencing of MSTO1 in HeLa cells reproduced the impairment of mitochondrial morphology and dynamics observed in the fibroblasts without damaging bioenergetics.[ncbi.nlm.nih.gov]

  • Autosomal Recessive Isolated Optic Atrophy

    network fragmentation.[genome.jp] Stenzel W, Graf R, van den Heuvel L, Ropers HH, Wienker TF, Hubner C, Langer T, Kaindl AM Title Homozygous YME1L1 mutation causes mitochondriopathy with optic atrophy and mitochondrial[genome.jp]

  • Autosomal Dominant Optic Atrophy

    Here we show that down-regulation of OPA1 in HeLa cells using specific small interfering RNA (siRNA) leads to fragmentation of the mitochondrial network concomitantly to the[wikigenes.org] Downregulation of OPA1 leads to fragmentation of the mitochondrial network and dissipation of the mitochondrial membrane potential with cytochrome c release and caspase-dependent[ncbi.nlm.nih.gov] OPA1 appears to exert its function in mitochondrial biogenesis and stabilization of mitochondrial membrane integrity.[ncbi.nlm.nih.gov]

  • Chronic Progressive External Ophthalmoplegia

    […] protein synthesis and fragmented mitochondrial networks, leading to neurodegeneration ( Almajan et al. , 2012 ).[doi.org] network fragmentation, Human Mutation, 39, 12, (2060-2071), (2018).[doi.org] […] calcium uptake via organellar network fragmentation , Hum Mol Genet , 2012 , vol. 21 (pg. 3858 - 70 ) Paraplegin gene analysis in hereditary spastic paraparesis (HSP) pedigrees[doi.org]

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