Freckles: Causes & Reasons

Possible Causes for Freckles

In some individuals, the freckles fade with age, however the disorder can be present in the absence of skin pigmentation. [nationwidechildrens.org]

These freckles are harmless and begin to appear very early in childhood and then may disappear into adulthood. [cancer.nsw.gov.au]

Nostrils, hands/fingers/toes, anus and vulva may also show freckling. [insight-group.org]

UV-Sensitive Syndrome 1

OMIM : 58 UV-sensitive syndrome-1 is an autosomal recessive disorder characterized by cutaneous photosensitivity and mild freckling, without an increased risk of skin tumors [malacards.org]

A rare autosomal recessive disorder (OMIM:600630) characterised by photosensitivity, mild freckling hypopigmented spots, telangiectases, and slightly dried skin in sun-exposed [medical-dictionary.thefreedictionary.com]

Some healthy people have photosensitivity and numerous freckles and marked dark spots. [osaka-u.ac.jp]

Xeroderma Pigmentosum Complementation Group B

The skin develops marked freckling and other pigmentation abnormalities. [uniprot.org]

Xeroderma pigmentosum (XP) is characterized by: Acute sun sensitivity (severe sunburn with blistering, persistent erythema on minimal sun exposure) with marked freckle-like [ncbi.nlm.nih.gov]

Hypogonadism Abnormality of the eye Cataract Microphthalmia Optic atrophy Pigmentary retinopathy Abnormality of the integument Cutaneous photosensitivity Dermal atrophy Freckling [ncbi.nlm.nih.gov]

UV-Sensitive Syndrome Type 2

Abstract UV-sensitive syndrome (UVsS) is a rare autosomal recessive disorder characterized by photosensitivity and mild freckling but without neurological abnormalities or [ncbi.nlm.nih.gov]

Abstract UV sensitive syndrome (UV s S) is a rare autosomal recessive disorder characterized by solar sensitivity and freckling, but no neurological abnormality and skin tumors [jstage.jst.go.jp]

ADULT Syndrome

Bald scalp also showed increased freckling and xerosis [ Figure 1a : arrowheads]. Freckling was also noted in photo distribution. [ncbi.nlm.nih.gov]

Excessive freckling in sun exposed areas may be present as well as lacrimal duct atresia (causing chronic conjunctivitis and blepharitis) and breast/nipple hypoplasia. [geneskin.org]

Individuals diagnosed with ADULT syndrome tend to display prominent or excessive freckling. [ectodermaldysplasia.ca]

Carney Complex Type 1

They differ from the common freckles in that there is actual hyperplasia of melanocytes, whereas freckles have normal numbers of melanocytes that produce increased pigment [visualdx.com]

[…] described as the association of: (1) primary pigmented nodular adrenocortical disease (PPNAD), a pituitary-independent, primary form of hyperadrenocortisolism; (2) lentigines, freckles [medical-dictionary.thefreedictionary.com]

Ephelides (freckles [6] ). Pronounced e-FEE-le-DEEs. [7] LAMB LAMB: Lentigines. Focal melanocyte hyperplasia. Atrial myxomas. Mucocutaneous myxomas. Blue nevi. [librepathology.org]

Waardenburg Syndrome Type 2E

[…] have neurologic abnormalities Mental retardation Increased muscle tone Skeletal Skull Bilateral temporal bone abnormalities Skin Nails Hair Skin Hypopigmented skin patches Freckles [mnglabs.com]

Sunburn

Other risk factors include a fair complexion, found commonly in people with blueor green eyes, freckles, and light-colored hair (The Skin Cancer Foundation, 2008). [ncbi.nlm.nih.gov]

Types 1 and 2: High Susceptibility to Sunburn People with Skin Type 1 have very fair skin (pale or milky white), blonde or red hair, and possibly freckles. [medicinenet.com]

The adjusted prevalence of sunburn was particularly common among adults aged 18-29years (52.0%), those who repeatedly burn or freckle after 2weeks in the sun (45.9%), whites [ncbi.nlm.nih.gov]

Skin Neoplasm

Ephelis (freckles) Lentigo (age spots) Naevocellular naevi (moles) Melanome What is the microscopic appearance of epidermal cysts? [brainscape.com]

Trails and patches of freckles are telltale signs of your skin telling you that it is damaged. [skinnv.wordpress.com]

Freckles; discolored areas of the skin, called mottled pigmentation; and sallowness, yellow discoloration of the skin. [my.clevelandclinic.org]

Malignant Neoplasm of the Skin

However, freckles, moles or sunspots are warning signs that your skin has had too much sun exposure and you may be at greater risk of developing skin cancer. [mydr.com.au]

See your GP as soon as possible if you notice changes in a mole, freckle or patch of skin, particularly if the changes happen over a few weeks or months NHS The most common [express.co.uk]

Change in a mole or freckle. [cooperhealth.org]

Lentigo Maligna Melanoma

From Wikidata Jump to navigation Jump to search No description defined Hutchison melanotic freckle Malignant Lentigo Melanoma LMM Lentigo Maligna Melanoma edit English Lentigo [wikidata.org]

Lentigo maligna melanoma usually develops on the face or nose from a melanotic freckle, often spreading aggressively. [medicinenet.com]

Benign freckles, or ephelides, of the cheeks and nose demonstrating discrete, small, pigmented macules. Figure 5. Differential diagnosis. [aao.org]

Malignant Melanoma in Childhood

Become familiar with your child's skin and the pattern of moles, freckles, and other marks on his or her body. [danafarberbostonchildrens.org]

Examine your skin often for new skin growths or changes in existing moles, freckles, bumps and birthmarks. [mayoclinic.org]

Giant congenital naevus Fitzpatrick skin phototypes I-II (i.e. fair skin that burns easily and tans poorly, freckles) Immunodeficiency or immunosuppression History of retinoblastoma [dermnetnz.org]

Nodular Malignant Melanoma

They look like a freckle, but they're usually larger, darker and stand out more than a normal freckle. They can gradually get bigger and may change shape. [nhs.uk]

It is also known as "Hutchinson's melanotic freckle".[3] This is named for Jonathan Hutchinson.[4][5] The word lentiginous comes from the latin for freckle. [en.wikipedia.org]

The presence of freckles is a marker for the amount of sun damage one has had. [aimatmelanoma.org]

Malignant Melanoma of the Skin

Light skin colour and high freckle density were also highly significant risk factors, independent of each other and of naevus count and hair and eye colour. [ncbi.nlm.nih.gov]

Sturm and Eirikur Steingrimsson, Sun‐induced freckling: ephelides and solar lentigines, Pigment Cell & Melanoma Research, 27, 3, (339-350), (2014). M. Binstock, F. [doi.org]

They look like a freckle but they're usually larger, darker and stand out more than a normal freckle. They can gradually get bigger and may change shape. [www2.hse.ie]

Superficial Spreading Melanoma

They look like a freckle, but they're usually larger, darker and stand out more than a normal freckle. They can gradually get bigger and may change shape. [nhs.uk]

They look like a freckle but they're usually larger, darker and stand out more than a normal freckle. They can gradually get bigger and may change shape. [www2.hse.ie]

Superficial spreading melanoma sometimes looks like a freckle, which can make it hard to recognize. [healthline.com]

Neurofibroma

Axillary freckling and inguinal freckling often develop during puberty. [emedicine.medscape.com]

Freckling Freckling in the armpits is also known as Crowe sign and is characteristic of neurofibromatosis type 1. [dermnetnz.org]

Unlike NF1, skin discoloration and freckles are few or nonexistent in people with NF2. [medbroadcast.com]

Legius Syndrome

Café‐au‐lait macules and intertriginous freckling in piebaldism: Clinical overlap with neurofibromatosis type 1 and Legius syndrome. [onlinelibrary.wiley.com]

Description Legius syndrome, historically known as Neurofibromatosis type 1-like syndrome (NFLS), is characterized by multiple café-au-lait spots with or without additional freckle-like [medicover-genetics.com]

Individuals frequently fulfill the NIH diagnostic criteria for NF1 based on pigmentary manifestations of café-au-lait spots and distinctive freckling patterns. [arup.utah.edu]

Plexiform Neurofibroma

[…] of the right lower aspect of the trunk of a 1-year-old girl with a diffuse and plexiform neurofibroma in the same area, numerous café-au-lait macules, and intertriginous freckling [ncbi.nlm.nih.gov]

On physical examination, there were multiple café-au-lait spots larger than 15 mm in diameter scattered over the patient's entire body and axillary freckling, but no cutaneous [ncbi.nlm.nih.gov]

Left axillary freckling was also present. On ocular examination, the patient could fix and follow with both eyes. [meajo.org]

Neurofibromatosis

In the present study 2 patients of paraplegia had multiple neurofibromas with cafe-au-lait spots and axillary freckles, one among them had spinal neurofibromas, and one had [medical-dictionary.thefreedictionary.com]

A child with NF1 is likely to have at least six or more of these spots that are larger than freckles. [clevelandclinic.org]

The following symptoms appear in people with NF1: Several (usually 6 or more) café au lait spots Multiple freckles in the armpit or groin area Tiny growths in the iris (colored [webmd.com]

Neurofibromatosis Type 2

Axillary freckling and inguinal freckling often develop during puberty. [emedicine.com]

Intertriginous freckling develops starting at 5 years. Multiple cutaneous and subcutaneous neurofibromas develop in adults. [web.archive.org]

Axillary freckling Axillary freckling (as well as freckling on the perineum), known as the Crowe sign, is a helpful diagnostic feature in neurofibromatosis (see the image [emedicine.com]

Xeroderma Pigmentosum

The earliest lesions are usually irregular freckling and marked dryness of the sun-exposed areas. [dermis.net]

Other features of XP include very dry skin (xeroderma), blisters on the skin, heavy freckling, and dark spots on the skin. [medicinenet.com]

Zosteriform Lentiginosis

Liver spots (old age spots, senile freckles, sun freckles, solar lentigo, lentigo senilis) are patches or blemishes on the skin that look like large freckles, but which are [sej-ramme.pw]

(39 %) ( Ephelis,) Ephelis (39 %) ( Freckle,) Dyschromatosis Universalis Hereditaria (39 %) Hidrocystoma (39 %) ( Cystadenoma, Molls Gland Cyst, Sudoriferous Cyst,) Lentigo [gulfdoctor.net]

Lentigines can be localized and must be distinguished from freckles (ephelides). [what-when-how.com]

Familial Melanoma of the Eyelid

They look like a freckle but they're usually larger, darker and stand out more than a normal freckle. They can gradually get bigger and may change shape. [nhs.uk]

It develops from a slow-growing precancerous condition called a lentigo maligna or Hutchinson’s freckle. This looks like a stain on the skin. [macmillan.org.uk]

Fair skin, freckling, and light hair The risk of melanoma is much higher for whites than for African Americans. [cancer.org]

Iris Melanoma

You’re probably familiar with freckles on your skin, but did you know you can also get freckles in your eye? [healthline.com]

Carol Shields offers tips on differentiating iris melanoma from a freckle or nevus. [aao.org]

Iris Melanoma in Cats. synonyms: melanosis, iris freckles ... Intraocular (Eye) Melanoma - WebMD - Better information ... [drugster.info]

Xeroderma Pigmentosum-Cockayne Syndrome Complex

The patients of this syndrome present with photosensitivity, freckling on sun-exposed skin, loss of subcutaneous fat from face, prominent ears, dwarfism, microcephaly, mental [jpad.com.pk]

Heterozygous individuals are often heavily freckled. [medical-dictionary.thefreedictionary.com]

The clinical signs shared by these two brothers and the two other previously described patients include severe sun sensitivity, freckling, diminished stature, hearing and [ncbi.nlm.nih.gov]

Chloasma

(Credit: iStock/Getty Images) You thought it was just a freckle, but now there's a brown patch spreading above your upper lip. It could very well be melasma. [cbc.ca]

The vulva, areolas, and some freckles or mole, may stay darker even after the baby is born. [babymed.com]

"They just think pigmentation is pigmentation and they're treating it like a freckle. That can actually damage the skin and it can make it worse." [cbc.ca]

Malignant Choroidal Melanoma

You're more likely to get this cancer if you have a lot of freckles or moles on your body. [webmd.com]

Choroidal Nevus Like a raised freckle on the skin, a nevus can occur inside the eye. [eyecancermd.org]

A choroidal nevus is similar to a large freckle or mole found on the skin. [mastereyeassociates.com]

Jaffe-Campanacci Syndrome

Figure 1 Typical “coast-of-California” café-au-lait spots (a) and axillary freckles (b). [bmcmusculoskeletdisord.biomedcentral.com]

Abstract Background: Jaffe-Campanacci is a rare syndrome characterised by the association of café-au-lait spots, axillary freckles, multiple non-ossifying fibromas of the [mendeley.com]

The patient was born with multiple, variously sized café-au-lait spots and axillar freckling ( figure 1 ). [ncbi.nlm.nih.gov]

Familial Melanoma of the Lip

It develops from a slow-growing precancerous condition called a lentigo maligna or Hutchinson’s freckle. This looks like a stain on the skin. [macmillan.org.uk]

Some variants appear then to result in the production of phaeomelanin predominantly, with resultant red hair, freckles and sun sensitivity. [genomel.org]

Fair skin, freckling, and light hair The risk of melanoma is much higher for whites than for African Americans. [cancer.org]

17q11 Microdeletion Syndrome

The patient showed overgrowth, café au lait spots, inguinal freckling, and neurological abnormalities. [moh-it.pure.elsevier.com]

Phenotypes Abnormal heart morphology; Abnormality of cardiovascular system morphology; Attention deficit hyperactivity disorder; Autosomal dominant inheritance; Axillary freckling [mousephenotype.org]

[…] benign tumors called neurofibromas on the skin, plexiform neurofibromas (thick and misshapen nerves due to the abnormal growth of cells and tissues that cover the nerve), and freckles [checkorphan.org]