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41 Possible Causes for Free Carnitine Decreased

  • Cardiomyopathy

    free carnitine with a relative increase in acylcarnitine species. 43,44 D CM has been described in the setting of transient neonatal hypocalcemia and calcium/magnesium ratio[revportcardiol.org] […] the setting of multiorgan disease, thus warranting screening for lactic acidosis in these patients, who may present with elevated lactate and lactate/pyruvate ratio and decreased[revportcardiol.org]

  • Hypoxia

    The subsequent acylation of the carnitine pool has been suggested to result in a marked decrease in muscle free carnitine and downregulation of carnitine palmitoyltransferase[jissn.biomedcentral.com]

  • Dilated Cardiomyopathy

    free carnitine with a relative increase in acylcarnitine species. 43,44 D CM has been described in the setting of transient neonatal hypocalcemia and calcium/magnesium ratio[revportcardiol.org] […] the setting of multiorgan disease, thus warranting screening for lactic acidosis in these patients, who may present with elevated lactate and lactate/pyruvate ratio and decreased[revportcardiol.org]

  • Carnitine Deficiency

    This study demonstrated that decreased free carnitine levels were independently associated with AMS scale and SDS in male HD patients.[ncbi.nlm.nih.gov] Abstract Valproic acid enhances renal losses of carnitine esters and leads to decreased plasma free carnitine concentrations in many patients receiving valproic acid therapy[ncbi.nlm.nih.gov] […] and urine free carnitine levels.[ncbi.nlm.nih.gov]

  • Rhabdomyolysis

    Clinical examination was normal, creatine kinase levels were elevated, plasma free carnitine concentration was mildly decreased, muscle biopsy demonstrated lipid accumulation[ncbi.nlm.nih.gov] We describe the case of a 57-year-old man with recurrent exertional rhabdomyolysis who was diagnosed with systemic primary carnitine deficiency (SPCD).[ncbi.nlm.nih.gov]

  • Thalassemia Minor

    Free and total plasma carnitine concentration and hemoglobin levels in BTM subjects increased significantly after carnitine supplementation (P .0001).[ncbi.nlm.nih.gov] Bone pain complaint and muscle weakness decreased with carnitine. Red blood cell folate level increased after folic acid supplementation.[ncbi.nlm.nih.gov]

  • MELAS Syndrome

    Reduced level of free carnitine. Presence of ethylmalonic acid in urine organic acid profile. 15. Cont.[slideshare.net] Muscle biopsy Decreased activity of complex III of the electron transport chain. Normal mtDNA Normal histology on light microscopy examination. 16.[slideshare.net]

  • Short Chain Acyl CoA Dehydrogenase Deficiency

    Serum carnitine was decreased (total, 18.2 micromol/L; free, 11.7 micromol/L).[ncbi.nlm.nih.gov] Methods and Results: Serum carnitine was decreased (total, 18.2 μmol/L; free, 11.7 μmol/L).[neurology.org] Muscle biopsy at 3 years revealed type I fiber predominance and hypotrophy, multicores with a focal decrease in mitochondria and oxidative enzymes, and internal nuclei.[ncbi.nlm.nih.gov]

  • Alcoholic Ketoacidosis

    Carnitine acyltransferase (CAT) transports free fatty acids into the mitochondria and therefore regulates their entry into the oxidative pathway.[emedicine.com] The decreased insulin-to-glucagon ratio that occurs in starvation indirectly reduces the inhibition on CAT activity, thereby allowing more free fatty acids to undergo oxidation[emedicine.com]

  • Isovaleric Acidemia

    Retrospective analysis revealed that most patients with moderate to severe forms of IVA have decreased free-carnitine levels shortly after birth and higher levels of IVG than[ncbi.nlm.nih.gov] Plasma isovalerylcarnitine level was drastically decreased from the second trimester and free carnitine was inversely increased, suggesting reduced production of isovaleryl-CoA[ncbi.nlm.nih.gov] MMA measurement in DBS was thought to provide useful information about the severity of MMAU, as MMAU patients with high levels of MMA had decreased levels of free carnitine[ncbi.nlm.nih.gov]

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