Gangrene: Causes & Reasons

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Possible Causes for Gangrene

Raynaud Syndrome

The only treatment available for gangrene is amputation, resulting in permanent disability. [jmedicalcasereports.biomedcentral.com]

These sores may progress to gangrene. In rare cases, gangrene may lead to finger amputation. [hopkinsmedicine.org]

Though benign, it can result in severe ulceration and ultimately gangrene associated with disfiguration and permanent deformity. [jmedicalcasereports.biomedcentral.com]

Raynaud Disease

[…] disease Raynaud's disease Raynauds disease w gangrene Raynauds disease with gangrene Raynauds syndrome Raynauds syndrome w gangrene Raynauds syndrome with gangrene Secondary [icd9data.com]

[…] of the toes Gangrene of the fingertips Extreme constriction of blood vessels (peripheral) Tissue hypoxia Skin, muscle, and tissue atrophy Ulceration Ischemic gangrene Raynaud [disability-benefits-help.org]

Severe secondary Raynaud's can cause skin sores or gangrene. "Gangrene" refers to the death or decay of body tissues. Fortunately, severe Raynaud's is rare. [web.archive.org]

Arteriosclerosis

BACKGROUND: Guillotine below-knee amputation (BKA) for wet gangrene is an unfortunate complication of poorly controlled diabetes. [ncbi.nlm.nih.gov]

In severe arteriosclerosis the affected extremity may develop gangrene. In these cases amputation may be necessary. [medrounds.org]

Arteriosclerosis obliterans resulted in serious lower extremity gangrene. [ncbi.nlm.nih.gov]

Hernia

[…] or gangrene, bilateral, recurrent convert 550.93 to ICD-10-CM [icd9data.com]

553- > 553 Other hernia of abdominal cavity without mention of obstruction or gangrene 553.0 Femoral hernia without mention of obstruction or gangrene 553.00 Femoral hernia [icd9data.com]

551 Other hernia of abdominal cavity with gangrene 551.0 Femoral hernia with gangrene 551.00 Femoral hernia with gangrene, unilateral or unspecified (not specified as recurrent [icd9data.com]

Erysipelas

The most common complications of erysipelas include abscess, gangrene, and thrombophlebitis. [symptoma.com]

1 n an acute streptococcal infection characterized by deep-red inflammation of the skin and mucous membranes Type of: Saint Anthony's fire any of several inflammatory or gangrenous [vocabulary.com]

Ischemia of the calf predisposes to gangrene and ulcer formation which can develop to giant proportions. [hindawi.com]

Arterial Embolism

Twelve patients did not present until the affected limb(s) were in established gangrene. Thirty-two embolectomies were performed on 25 patients. [ncbi.nlm.nih.gov]

(B) Gangrene of the toes resulting from severe arterial ischemia. (C) Ulcer from v... [5minuteconsult.com]

She developed gangrene in her right hand, which had progressed to the point that amputation was necessary by the time the gastrointestinal surgeon had consulted the Department [ncbi.nlm.nih.gov]

Intussusception

He was referred to pediatric surgical department and underwent laparotomy confirming ileocecal intussusception with resection of gangrenous part of his large and small bowel [ncbi.nlm.nih.gov]

If this is not treated quickly, it can lead to bowel gangrene. Gangrene can cause tissue in the intestinal wall to die. [cancercarewny.com]

The telescoping segment obstructs the intestine and ultimately impairs blood flow to the intussuscepting segment (see Figure: Intussusception. ), causing ischemia, gangrene [msdmanuals.com]

Necrotizing Fasciitis

Necrotizing fasciitis w gangrene due to infectious organism Necrotizing fasciitis with gangrene Clinical Information A fulminating bacterial infection of the deep layers [icd9data.com]

Infected tissue with gas-inclusion between the muscle fibers Gram positive rods Gluteal gas gangrene with necrotizing fasciitis Gas gangrene Necrotic muscle with gas bubbles [pathologyoutlines.com]

Later, "hospital gangrene" became more commonly used. [en.wikipedia.org]

Thromboangiitis Obliterans

2018 2019 Billable/Specific Code Applicable To Gangrenous cellulitis Type 1 Excludes gangrene in atherosclerosis of native arteries of the extremities ( I70.26 ) gangrene [icd10data.com]

Minor amputations of gangrenous tissue are often needed. [medical-dictionary.thefreedictionary.com]

gangrenous (connective tissue) (dropsical) (dry) (moist) (skin) (ulcer) I96 - see also Necrosis ICD-10-CM Diagnosis Code I96 Gangrene, not elsewhere classified 2016 2017 [icd10data.com]

Diabetic Gangrene

The fingers and toes with gangrene were amputated. The pathological diagnosis was diabetic gangrene. [ncbi.nlm.nih.gov]

Diabetic gangrene is a non-healing skin ulcer that is often resistant to most common treatments. [ncbi.nlm.nih.gov]

The foot gangrene itself and the local circulation around the gangrene lesion were remarkably improved after treatment with LDL-apheresis. [ncbi.nlm.nih.gov]

Pyoderma Gangrenosum

gangrene of certain specified sites - see Alphabetical Index gas gangrene ( A48.0 ) pyoderma gangrenosum ( L88 ) Type 2 Excludes gangrene in diabetes mellitus ( E08-E13 with [icd10data.com]

From pyoderma + scientific Latin gangrenosum, neuter singular of gangrenosus gangrenous. Pronunciation pyoderma gangrenosum /ˌpʌɪə(ʊ)ˈdəːmə ˌɡaŋɡrɪˈnəʊzəm/ [en.oxforddictionaries.com]

not elsewhere classified 2016 2017 2018 2019 Billable/Specific Code Applicable To Gangrenous cellulitis Type 1 Excludes gangrene in atherosclerosis of native arteries of [icd10data.com]

Ergotism

Anthony fire - any of several inflammations or gangrenous skin conditions. Synonym(s): ergotism; Milian sign ergotism see rye ergot 1. [medical-dictionary.thefreedictionary.com]

Anthony fire - any of several inflammations or gangrenous skin conditions. Synonym(s): ergotism; Milian sign ergotism see rye ergot 1 . [medical-dictionary.thefreedictionary.com]

Convulsive ergotism shares many clinical features with serotonin syndrome, while gangrenous ergotism is a form of dry gangrene due to vasoconstriction, most often of the lower [visualdx.com]

Cryoglobulinemia

The development of gangrene after elective digital surgery is a rare complication. [ncbi.nlm.nih.gov]

To our knowledge this is the first instance in which gangrene has been associated with cryoglobulinemia. FULL TEXT [annals.org]

In this report, we describe a case of a patient presented with gangrene of almost all fingers and toes, who was finally diagnosed and treated as cryoglobulinemic vasculitis [ncbi.nlm.nih.gov]

Calcinosis Cutis

In very rare cases, Calcinosis Cutis can cause gangrene due to blockage of blood flow. [epainassist.com]

[…] especially when there is secondary or tertiary hyperparathyroidism Painful violaceous lesions, most common on the trunk and extremities, which may progress to form ulcers and gangrene [dermpedia.org]

In extremely rare instances, there is development of gangrene. How is Calcinosis Cutis Diagnosed? [epainassist.com]

Gas Gangrene

(see also Gangrene, gas) 040.0 Clostridium perfringens or welchii (see also Gangrene, gas) 040.0 emphysematous (see also Gangrene, gas) 040.0 gas (bacillus) 040.0 Gas 787.3 [icd9data.com]

[…] than posttruamatic and postoperative gas gangrene. [symptoma.com]

Clostridium perfringens (C.P) gas gangrene is one of the most fulminant infectious diseases. [ncbi.nlm.nih.gov]

Frostbite

Gangrene of the extremities in the neonatal period is rare. Etiology is not identified in most cases and management is usually conservative. [ncbi.nlm.nih.gov]

Wet gangrene is characterized by infection, but dry gangrene is less likely to become infected. Severely damaged tissue may autoamputate. [merckmanuals.com]

We describe an unusual case of an abandoned neonate with marked hypothermia, who was brought to us with gangrene of toes, during a severe winter. [ncbi.nlm.nih.gov]

Polyarteritis Nodosa

We will illustrate a challenging case of a patient with CPAN who developed gangrenous infarcts despite initial immunosuppressive treatment with high-dose steroids and azathioprine [ncbi.nlm.nih.gov]

[…] pain Systemic hypertension Anorexia and weight loss Abdominal distention Hematemesis, melena Jaundice Painless hematuria Peripheral neuropathy Tender subcutaneous nodules Gangrene [learningradiology.com]

Acalculous gangrenous cholecystitis may develop owing to arteritis involving the wall of the gallbladder. [ncbi.nlm.nih.gov]

Noma

Abstract Necrotising ulcerative stomatitis is used in the International Statistical Classification of the WHO for orofacial gangrene in children, that is known in medical [ncbi.nlm.nih.gov]

Noma (cancrum oris, gangrenous stomatitis) is a severe gangrenous disease of orofacial tissues seen in malnourished children. [symptoma.com]

Noma neonatorum is a gangrenous process that occurs in the oral, nasal or anal area and occasionally the eyelids and scrotum of the newborn. [ncbi.nlm.nih.gov]

Tungiasis

Complications, though rare, may involve ulceration, gangrene, secondary infection, tetanus, and death. [web.stanford.edu]

But elsewhere, this parasitic flea causes an inflammatory skin disease called tungiasis, which can lead to gangrene, amputations and painful lesions. [globalhealthnow.org]

It can be life-threatening at times Gangrene – this can cause swelling, pain, sores, and blisters. [news-medical.net]

Erythromelalgia

It is possible to get ulceration, necrosis and gangrene as complications of erythromelalgia. [dermnetnz.org]

Quality of life can be greatly affected due pain and disability due to pain, secondary tissue damage (ulcers, necrosis, gangrene) or self-harming behaviours can be an issue [dermnetnz.org]

This can also lead to maceration of the skin, non-healing ulcers, infection, gangrene and amputation. [dermnetnz.org]

Primary Hyperoxaluria Type 1

[ohf.org] Gangrene Arteriole occlusive disease may lead to gangrene, Raynaud phenomena, acrocyanosis and intermittent claudication. Renal failure is common. [symptoma.com]

Case Reports Primary hyperoxaluria causing ESRD and gangrene of extremities leading to amputation Nidhi M Munshi et al. Hemodial Int. 2009 Jul. [pubmed.ncbi.nlm.nih.gov]

Arteriole occlusive disease may lead to gangrene, Raynaud phenomena, acrocyanosis and intermittent claudication. Renal failure is common. [disorders.eyes.arizona.edu]

Primary Hyperoxaluria

Arteriole occlusive disease may lead to gangrene, Raynaud phenomena, acrocyanosis and intermittent claudication. Renal failure is common. [disorders.eyes.arizona.edu]

The ongoing systemic oxalosis also may lead to other clinical manifestations such as cardiac conduction defects, vascular calcification with distal gangrene, disturbed vision [orpha.net]

skin (livedo reticularis, calcinosis cutis metastatica, gangrene), bone (pain, joint immobility, anemia, fractures) and central nervous system (Curr Rheumatol Rep 2013; [pathologyoutlines.com]

Rocky Mountain Spotted Fever

Pathophysiologically, gangrene is most likely related to small-vessel occlusion. [ncbi.nlm.nih.gov]

A case of Rocky Mountain spotted fever complicated by gangrene of the extremities required amputation and showed persistent rickettsial infection in the margins of the gangrene [ncbi.nlm.nih.gov]

Breathing becomes laboured and circulation poor, and areas of gangrene may develop on the hands and feet. [britannica.com]

Primary Hyperoxaluria Type 2

[ohf.org] Gangrene Arteriole occlusive disease may lead to gangrene, Raynaud phenomena, acrocyanosis and intermittent claudication. Renal failure is common. [symptoma.com]

Case Reports Primary hyperoxaluria causing ESRD and gangrene of extremities leading to amputation Nidhi M Munshi et al. Hemodial Int. 2009 Jul. [pubmed.ncbi.nlm.nih.gov]

Arteriole occlusive disease may lead to gangrene, Raynaud phenomena, acrocyanosis and intermittent claudication. Renal failure is common. [disorders.eyes.arizona.edu]

Paroxysmal Cold Hemoglobinuria

The gangrenous digits (right index and ring fingers) remained well demarcated, requiring surgical amputation. [ijcasereportsandimages.com]

Cursor on image to zoom/Click text to open image Figure 1: Gangrenous fingers of our patient. Discussion The PCH was first described by Donath and Landsteiner in 1904. [edoriumjournals.com]

Vasomotor signs include cyanosis, Raynaud phenomenon, and gangrene. [forums.prohealth.com]

Cutaneous Plague

A critically ill patient with septicemic plague and peripheral gangrene was treated successfully with ciprofloxacin. [ncbi.nlm.nih.gov]

It can cause rapid blood poisoning and gangrene, known as septicemic plague. [theverge.com]

Its victims were covered in huge weeping boils, swollen lymph glands, gangrene and rotting limbs and eventually succumbed to a slow an painful death. [express.co.uk]

Embolism

It is often due to embolism of infective material, gangrenous matter, etc. [thesaurus.com]

In cases where the limb is affected and it has developed to gangrene, the affected limb should be amputated. [symptoma.com]

Embolism plays an important part in determining one form of gangrene, as has already been described. [thesaurus.com]

Clostridium Infection

Septic abortion Clinically it appears similar to gas gangrene, now rare in UK with the legalisation of abortions. [patient.info]

Toxin Soft-tissue infection Crepitant cellulitis, myositis, clostridial myonecrosis, hemolysis C. perfringens, others Alpha-toxin (phospholipase C), theta-toxin, others Gas gangrene [merckmanuals.com]

See separate Gas Gangrene article. Tetanus Caused by Clostridium tetani. See separate Tetanus and Tetanus Vaccination article. [patient.info]

Thrombosis

Examinations after death have shown that thrombosis exists for some distance around the gangrenous mass. [thesaurus.com]

Venous gangrene may result. Infection rarely develops in venous clots. [merckmanuals.com]

[…] aortic atheroscloeric plaques – small pieces of atheromatous material break off and cause small artery occlusions à strokes, acute renal failure, “blue toe syndrome,” ulcers/gangrene [errolozdalga.com]

Peripheral Neuropathy

The development of gas gangrene coupled with Charcot neuroarthropathic changes ultimately resulted in a potentially life-saving transmetatarsal (TMT) amputation. [ncbi.nlm.nih.gov]

Gangrene If you do develop a wound infection in one of your feet as a result of peripheral neuropathy, there's a risk this could lead to gangrene (death of part of the skin [nhsdirect.wales.nhs.uk]

This can lead to gangrene (tissue death) if untreated, and in severe cases may mean the affected foot has to be amputated. [nhsdirect.wales.nhs.uk]