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168 Possible Causes for Gastrin Increased, Hypercalcemia, Vitamin B12 Deficiency, Zollinger Ellison Syndrome

  • Primary Hyperparathyroidism

    Hypercalcemia is found frequently in patients with cancer.[ncbi.nlm.nih.gov] Patients' electronic hospital records were evaluated for a positive history of thyroid diseases, diabetes mellitus, primary hyperparathyroidism, vitamin B12 deficiency, and[ncbi.nlm.nih.gov] The coexistence of familial hypocalciuric hypercalcemia (FHH) and primary hyperparathyroidism (PHPT) is extremely rare.[ncbi.nlm.nih.gov] Significant hypercalcemia was associated with nephrolithiasis, but interestingly, patients with milder hypercalcemia had significantly more depression, bone or joint pain,[ncbi.nlm.nih.gov]

  • Zollinger Ellison Syndrome

    Surgery to correct the hypercalcemia significantly ameliorates the ZES.[ncbi.nlm.nih.gov] The Zollinger-Ellison syndrome, which is due to the secretion of gastrin from non-beta islet cell tumors of the pancreas, results in gastric hypersecretion and severe peptic[ncbi.nlm.nih.gov] RESULTS: A gastrin increase of 100 ng/l was found to be the most sensitive and specific criterion for a positive test.[ncbi.nlm.nih.gov] Clinical Features of ZES Less frequently, ZES may present as: Vitamin B12 malabsorption: This deficiency may developbecause low intraluminal intestinal pH interferes with[gastrointestinalatlas.com]

  • Multiple Endocrine Neoplasia

    The patient was treated with everolimus, and showed complete resolution of hypercalcemia and tumor control for 3 years when he presented with pulmonary cryptococcosis and[ncbi.nlm.nih.gov] In type 1 multiple endocrine neoplasia (MEN1), esophageal diseases association with excessive gastrin secretion in Zollinger-Ellison syndrome (ZES) sometimes develop.[ncbi.nlm.nih.gov] Growth hormone: increased growth of the jaw and other tissues Adrenocorticotropic hormone: increased production of cortisol Gastrin: increased risk of stomach ulcers Glucagon[news-medical.net] The resulting clinical signs include HYPERPARATHYROIDISM; HYPERCALCEMIA; HYPERPROLACTINEMIA; CUSHING DISEASE; GASTRINOMA; and ZOLLINGER-ELLISON SYNDROME.[linkedlifedata.com]

    Missing: Vitamin B12 Deficiency
  • Multiple Endocrine Neoplasia Type 1

    Hypercalcemia and elevated PTHrP improved markedly with hepatic artery chemoembolization of liver metastasis.[ncbi.nlm.nih.gov] Abrupt discontinuation of proton pump therapy can lead to adverse outcomes in patients with Zollinger-Ellison syndrome.[ncbi.nlm.nih.gov] Growth hormone: increased growth of the jaw and other tissues Adrenocorticotropic hormone: increased production of cortisol Gastrin: increased risk of stomach ulcers Glucagon[news-medical.net] . • Hypercalcemia may increase gastrin secretion from gastrinoma 10.[slideshare.net]

    Missing: Vitamin B12 Deficiency
  • Antral G-Cell Hyperplasia

    (RadioGraphics March-April 2006 vol. 26 no. 2 453-464) The patient had a history of nephrolithiasis, hypercalcemia, hyperuricemia, and peptic ulcer disease.[flipper.diff.org] Differentiation between AGCH (pseudo-Zollinger-Ellison syndrome) and an extragastric gastrin-secreting tumour (true Zollinger-Ellison syndrome) was made on the basis of the[link.springer.com] Increased G cells in the antrum. Produce gastrin to stimulate the (missing) parietal cells. Notes: Compare with other types of gastric atrophy.[librepathology.org] B12 deficiency Epidemiology Reported prevalence rate of 1-2% among older patients and in high-incidence countries (Nordic Europe) The classic form of the disease tends to[humpath.com]

  • Pernicious Anemia

    These ilium-related disorders include tropical sprue, Whipple's disease, Crohn's disease, tuberculosis, and the Zollinger-Ellison syndrome .[encyclopedia.com] Serum gastrin level was increased, urinary 5-hydroxyindoleacetic acid was within the normal range.[ncbi.nlm.nih.gov] BACKGROUND: Vitamin B12 deficiency may result in pernicious anemia (PA). This study evaluated whether all the patients with vitamin B12 deficiency had PA.[ncbi.nlm.nih.gov] These ilium-related disorders include tropical sprue, Whipple's disease, Crohn's disease, tuberculosis, and the Zollinger-Ellison syndrome.[encyclopedia.com]

    Missing: Hypercalcemia
  • Achlorhydria

    The massive amounts of VIP secretion cause watery diarrhea, hypokalemia, achlorhydria, vasodilation, hypercalcemia, and hyperglycemia.[ncbi.nlm.nih.gov] Patients with the Zollinger-Ellison syndrome did not demonstrate positive PCA despite elevated levels of basal gastrin, nor was PCA present in normal controls.[ncbi.nlm.nih.gov] (ii) There is a negative correlation between fasting plasma gastrin concentrations and the percentage increase in plasma gastrin levels in response to meal stimulation.[ncbi.nlm.nih.gov] One of these is pernicious anemia, caused by vitamin B12 deficiency.[wisegeek.com]

  • Dyspepsia

    SYSTEMIC • Renal failureDISEASES • Hypercalcemia 10. • NSAIDS • Iron and potassiumDRUGS supplements • Corticosteroids • Digoxin 11.[slideshare.net] Tetracyclines Theophylline Tricyclic Antidepressants Zidovudine Diabetes Asthma GERD Hiatal Hernia Motility disorders (eg, gastroparesis) Pregnancy Peptic ulcer disease Scleroderma Zollinger-Ellison[pharmacytimes.com] Stomach-brain communication by vagal afferents in response to luminal acid backdiffusion, gastrin, and gastric acid secretion.[dx.doi.org] B12 deficiency Long-term use of PPIs does not lead to vitamin B12 deficiency except possibly in elderly people, or in people with Zollinger-Ellison Syndrome who are on high[bpac.org.nz]

  • Graves Disease

    The possibility of their coexistence should therefore be taken into consideration in cases of hypercalcemia.[ncbi.nlm.nih.gov] B12 deficiency lupus , a chronic, long-term disorder that can affect many parts of your body Addison's disease, a hormonal disorder celiac disease , a digestive disorder[medicinenet.com] In addition to osteoporosis, hyperthyroidism can cause blood calcium levels to rise ( hypercalcemia ) by as much as 25%.[medicinenet.com] B12 deficiency lupus , a chronic, or long-term, disorder that can affect many parts of your body Addison’s disease , a hormonal disorder celiac disease , a digestive disorder[niddk.nih.gov]

    Missing: Zollinger Ellison Syndrome
  • Atrophic Gastritis

    Ellison syndrome Special types Collagenous Lymphocytic Eosinophilic gastroenteritis Granulomatous Vascular Gastric vascular antral ectasia (GAVE) Portal hypertensive gastropathy[surgpathcriteria.stanford.edu] Increased G cells in the antrum. Produce gastrin to stimulate the (missing) parietal cells. Notes: Compare with other types of gastric atrophy.[librepathology.org] CAG and H. pylori infection are risk factors for vitamin B12 deficiency and peripheral neuropathy.[ncbi.nlm.nih.gov] 10-CM Diagnosis Code K29 Gastritis and duodenitis 2016 2017 2018 2019 Non-Billable/Non-Specific Code Type 1 Excludes eosinophilic gastritis or gastroenteritis ( K52.81 ) Zollinger-Ellison[icd10data.com]

    Missing: Hypercalcemia

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