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151 Possible Causes for Gastroesophageal Reflux Disease, Sore Mouth, T Cell Activation Increased

  • Systemic Scleroderma

    Levels of IL-4 are elevated in the sera of patients with SSc ( 83 ), and the number of IL-4–producing T cells is increased in their peripheral blood ( 84, 85 ).[jci.org] 0200042 Telangiectasia of the skin 0100585 Xerostomia Dry mouth Dry mouth syndrome Reduced salivation [ more ] 0000217 5%-29% of people have these symptoms Abnormal bowel[rarediseases.info.nih.gov] ., calcium channel blockers and angiotensin-II receptor blockers for Raynaud phenomenon, appropriate treatments for gastroesophageal reflux disease) and lifestyle modifications[ncbi.nlm.nih.gov]

  • Celiac Disease

    APC presents the toxic peptide to CD4 T cells. Activated gluten-reactive CD4 T-cells produce high levels of pro-inflammatory cytokines.[doi.org] […] problems such a canker sores or dry mouth seizures tingling numbness in the hands and feet tiredness weak and brittle bones Adults who have digestive symptoms with celiac[web.archive.org] Crohn disease (CrD), celiac disease, gastroesophageal reflux disease (GERD), and eosinophilic esophagitis (EoE).[ncbi.nlm.nih.gov]

  • Sjögren Syndrome

    Human exposure to an extremely high dose of TCDD in vivo induced a selective increase in the frequency of T cells producing IL-22 but not IL-17, IL-10, or IFN-γ ( 69 ).[doi.org] Other symptoms may include: Contact lens discomfort Dry sinuses and frequent sinus infections or nosebleeds Sore mouth, tongue or throat Difficulty chewing or swallowing Dry[allaboutvision.com] While nosebleeds and dry skin are irritating, even more severe manifestations of Sjogren's syndrome can lead to joint pain, a type of gastroesophageal reflux disease, and[massagetoday.com]

  • Food Allergy

    […] defects of permanent teeth Adults are less likely to have digestive signs and symptoms and may instead have one or more of the following: anemia bone or joint pain canker sores[web.archive.org] Common conditions that mimic EoE include gastroesophageal reflux disease and proton pump inhibitor-responsive esophageal eosinophilia.[ncbi.nlm.nih.gov] Memory T cells are increased in frequency and have distinct activation requirements and cell-surface proteins that distinguish them from armed effector T cells 10-25.[ncbi.nlm.nih.gov]

  • Hypersensitivity

    However, increased activation of CD4 T-cell and CD8 T-cells was only observed following four days of DDAB exposure.[ncbi.nlm.nih.gov] These sores can be found on the genitals, vagina, anus, rectum, lips and mouth. Pregnant women can transmit the disease to their unborn child.[niaid.nih.gov] Possible compounding factors included previous nasal trauma and extraesophageal manifestations of gastroesophageal reflux disease. 4 Whatever their causal mechanisms, the[web.archive.org]

  • Recurrent Oral Ulceration

    Patients with active RAS have an increased proportion of gamma-delta T cells compared with control subjects and patients with inactive RAS.[emedicine.medscape.com] Sores or localized abnormalities inside the mouth can arise from a number of causes. Mouth sores can occur on the tongue, gums, lips, or inside the cheeks.[medicinenet.com] When acid refluxes from the stomach into the esophagus, it is known as gastroesophageal reflux disease (GERD).[entnet.org]

  • Tongue Ulcer

    Interestingly, researchers say regular application of pure honey can heal oral ulcers in just 3 days![wowremedies.com] GERD (Acid Reflux, Heartburn) GERD (gastroesophageal reflux disease) is a condition in which the acidified liquid contents of the stomach backs up into the...[medicinenet.com] Patients with active RAS have an increased proportion of gamma-delta T cells compared with control subjects and patients with inactive RAS.[emedicine.medscape.com]

  • Mixed Connective Tissue Disease

    Similarly, in AIH-SLE/MCTD, CD4(pos)CD25(pos)CD25(high) T-regs were reduced in number and contained an increased proportion of activated CD127(pos) and IFNγ(pos) cells.[ncbi.nlm.nih.gov] Other symptoms of MCTD include: Photosensitivity (sensitivity to sunlight) Rashes Sores in the mouth and nose Swollen fingers or hands Muscle and joint pain Inflammation in[rileychildrens.org] Gastrointestinal – esophageal dysmotility, gastroesophageal reflux disease, dyspepsia Cardiac – pericarditis, chest pain Dermatologic – alopecia, heliotrope rash, Gottron[arupconsult.com]

  • Esophageal Candidiasis

    You may have cracking and redness at the corners of your mouth, difficulty while eating, and redness and soreness inside your mouth.[livestrong.com] It is important to differentiate esophageal candidiasis from other forms of infectious esophagitis such as cytomegalovirus, herpes simplex virus, gastroesophageal reflux disease[hindawi.com] [ 8 ], and treatment may lead to modest CD4 T-cell gains [ 3, 13 ] or a decrease in immune activation [ 14, 15 ].[academic.oup.com]

  • Eosinophilic Esophagitis

    Peripheral CD4 T cells show an increase in intracellular IL-5 in the blood of EE patients compared to non-atopic non-EE patients ( 10 ).[ncbi.nlm.nih.gov] ulcerations and significant weight loss of unknown origin.[ncbi.nlm.nih.gov] PURPOSE OF REVIEW: In this review, we discuss current diagnostic testing modalities for both gastroesophageal reflux disease (GERD) and eosinophilic esophagitis (EoE) and[ncbi.nlm.nih.gov]

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