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104 Possible Causes for Gastrointestinal Hemorrhage, Irinotecan, Peripheral Neuropathy

  • Adenocarcinoma of the Colon

    Cetuximab Monotherapy and Cetuximab plus Irinotecan in Irinotecan-Refractory Metastatic Colorectal .N Engl J Med 2004;351:337-45. 13. T. Delaunoit1, S.R. Alberts, D.J.[scielo.mec.pt] Patients who received FOLFOXIRI had significantly more grade 3 and 4 toxicities, including neutropenia, stomatitis, and peripheral neuropathy.[cancer.gov] Irinotecan 24,25 Days 1 and 8: Irinotecan 125mg/m 2 IV over 30–90 minutes. Repeat cycle every 3 weeks. OR Day 1: Irinotecan 300–350mg/m 2 IV over 30–90 minutes.[cancertherapyadvisor.com]

  • Malignant Gastric Neoplasm

    Irinotecan versus non‐irinotecan‐containing regimens for advanced gastric cancer Irinotecan versus non‐irinotecan‐containing regimens for advanced gastric cancer Patient or[doi.org] Side effects may include: tiredness nausea and vomiting nerve damage ( peripheral neuropathy ) hair loss diarrhoea anaemia (a lack of red blood cells) weight loss skin changes[nhs.uk] neuropathy and diarrhea.[dx.doi.org]

  • Cecal Adenocarcinoma

    Irinotecan 24,25 Days 1 and 8: Irinotecan 125mg/m 2 IV over 30–90 minutes. Repeat cycle every 3 weeks. OR Day 1: Irinotecan 300–350mg/m 2 IV over 30–90 minutes.[cancertherapyadvisor.com] […] perforation, wound healing complications, hemorrhage).[jcancer.org] Patients who received FOLFOXIRI had significantly more grade 3 and 4 toxicities, including neutropenia, stomatitis, and peripheral neuropathy.[cancer.gov]

  • Gastric Adenocarcinoma

    ., 5-FU (5 μ M); cisplatin (0.5 μ M); irinotecan (2.5 μ M); carboplatin (5 μ M); paclitaxel (2-4 n M); and X rays (1.8 Gy)] also potentiated gastric cancer clonogenic cell[ncbi.nlm.nih.gov] neuropathy grade 2 Inability to tolerate intravenous hydration e.g due to cardiac disease Co-morbidities (based on clinical judgement by the investigator) that in the view[clinicaltrials.gov] One of them was by Enzinger et al who reported that bevacizumab (Avastin, Genentech), cisplatin, docetaxel and irinotecan in a three-week cycle produced a response rate of[healio.com]

  • Malignant Neoplasm of Pancreas

    If you’re in fairly good health you may receive FOLFIRINOX (5-FU/ leucovorin / oxaliplatin / irinotecan ).[webmd.com] Acute and chronic pancreatitis, acute cholecystitis, upper gastrointestinal hemorrhage, neuropsychiatric disturbances, polyarthritis, painful skin nodules, pyrexia of unknown[omicsonline.org] […] may occur in either the central nervous system (CNS) or the peripheral nervous system (PNS).[en.wikipedia.org]

  • Esophageal Carcinoma

    Enzinger PC, Clark J, Bryan D et al. (2004) Phase II study of docetaxel, cisplatin, and irinotecan in advanced esophageal and gastric cancer.[springermedizin.de] The second case is an aortogastric tube fistula occurring in a 50-year-old male 2 years after surgery and resulting in fatal gastrointestinal hemorrhage.[ncbi.nlm.nih.gov] Physicians' Choice of Single Agent Docetaxel, Paclitaxel, or Irinotecan in Subjects with Advanced/Metastatic Adenocarcinoma...[clinicaltrialsregister.eu]

  • Adenocarcinoma of the Rectum

    He received intravenous chemotherapy 3 weeks after surgery, with standard doses of irinotecan and cisplatin.[academic.oup.com] "Urgent colonoscopy for evaluation and management of acute lower gastrointestinal hemorrhage: a randomized controlled trial".[en.wikipedia.org] Neuropathy A research study is evaluating an investigational treatment for chemotherapy induced peripheral neuropathy in patients with colorectal cancer (CRC).[centerwatch.com]

  • Colorectal Carcinoma

    The dose of irinotecan was 350 mg/m 2 every 21 days.[hungary.pure.elsevier.com] Patients who received FOLFOXIRI had significantly more grade 3 and 4 toxicities, including neutropenia, stomatitis, and peripheral neuropathy.[cancer.gov] WST-1 assay and X-CELLigence real time analysis were carried out for viability and proliferation testing before and after treatment with irinotecan and oxaliplatin.[ncbi.nlm.nih.gov]

  • Duodenal Carcinoma

    Many of these drugs commonly cause diarrhea, but it can be particularly bad with irinotecan.[cancer.org] […] tract hemorrhage is unusual. 1 , 7 , 8 The diagnosis may be difficult to make because the symptoms are vague and similar to those found in many benign conditions.[jamanetwork.com] neuropathy.[spandidos-publications.com]

  • Arsenic Trioxide

    BACKGROUND: After failing oxaliplatin-based first-line chemotherapy (CT), approximately 4%-21% of patients with metastatic colorectal cancer (mCRC) respond to irinotecan-based[ncbi.nlm.nih.gov] 3 8 Weight gain 5 13 Weight loss 3 8 Drug hypersensitivity 2 5 1 3 Gastrointestinal disorders Nausea 30 75 Anorexia 9 23 Appetite decreased 6 15 Diarrhea 21 53 Vomiting 23[rxlist.com] Nine weeks after the ingestion the only ongoing clinical issue was persistent but slowly improving peripheral neuropathy.[ncbi.nlm.nih.gov]

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