Generalized Darkening of the Skin: Causes & Reasons

Possible Causes for Generalized Darkening of the Skin

Generalized darkening of skin color. Fatigue. Joint pain. Lack of energy. Loss of body hair. Loss of sexual desire. Weakness. [medigoo.com]

Symptoms Symptoms may include any of the following: Abdominal pain Fatigue, lack of energy, weakness Generalized darkening of skin color (often referred to as bronzing) Joint [ufhealth.org]

Reynolds Syndrome

Overview Reynolds syndrome is a rare autoimmune disease, consisting of the combination of primary biliary cirrhosis and progressive systemic sclerosis. In some patients this syndrome has also been associated with Sjögren\'s syndrome and hemolytic anemia. Typical clinical features include jaundice, elevated blood levels[…] [checkorphan.org]

Carbon Baby Syndrome

The darkening of skin was first noticed over the feet and face at the age of 5 months and gradually progressed to involve the entire body. [ijdvl.com]

Case Report A 3-year-old female child born to non-consanguineous parents was brought to the dermatology department with history of generalized increase in pigmentation. [ijdvl.com]

Mandibuloacral Dysplasia with Type B Lipodystrophy

[…] lipodystrophy 0009064 Hyperlipidemia Elevated lipids in blood 0003077 Hyperpigmentation of the skin Patchy darkened skin 0000953 Insulin resistance Body fails to respond [rarediseases.info.nih.gov]

0001596 Calcinosis Calcium buildup in soft tissues of body 0003761 Convex nasal ridge Beaked nose Beaklike protrusion Hooked nose Polly beak nasal deformity [ more ] 0000444 Generalized [rarediseases.info.nih.gov]

Acanthosis Nigricans

Three months before the diagnosis of gastric adenocarcinoma was established, she had noticed a generalized darkening of the skin and small, velvety plaques on her neck. [doi.org]

In general, patients show an area of darkening and thickening of skin without any symptoms. Occasionally, pruritus may be seen. [symptoma.com]

skin darkening.[12] [edit] Acanthosis nigricans has been linked to the use of nicotinic acid,[4] glucocorticoid use, combined oral contraceptive pills, and growth hormone [en.wikipedia.org]

Familial Primary Localized Cutaneous Amyloidosis

Macular amyloidosis - mild to severely itchy, flat, dusky-brown or greyish colored spots that may come together to form patches of darkened skin. [rarediseases.info.nih.gov]

This rash generally affects the shins, thighs, feet and forearms. [rarediseases.info.nih.gov]

This rash generally appears on the upper back between the shoulder blades, the chest and less commonly, the arms. [rarediseases.info.nih.gov]

Cronkhite-Canada Syndrome

He also complained of marked loss of body hair, generalized darkening of skin color and brittleness of nails. [japi.org]

Autoimmune Polyendocrine Syndrome Type 1

[…] weakness and darkening of skin. [omjournal.org]

She also noticed darkening of skin color since last 1 year. She was mother of two children and had amenorrhea since last 8 years. [ncbi.nlm.nih.gov]

On further inquiry, he also gave history of generalized weakness, easy fatigability, postural dizziness, gradual darkening of skin and tongue for the last 6 months. [omjournal.org]

Chloasma

Definition / general Acquired large areas of darkened skin, usually due to hormonal changes (birth control pills, pregnancy) and usually on both sides of face ( eMedicine [pathologyoutlines.com]

PubMed Search : Melasma skin Page views in 2018: 2,838 Page views in 2019 to date: 270 Cite this page: Melasma. [pathologyoutlines.com]

Healing from inside: Chinese Herbal Medicine is prescribed to balance the hormonal system and nourish the skin to clear darkened patches on the skin. [meridianhealthclinic.com]

Localized Scleroderma

The condition generally lasts several years and then disappears on its own. But it usually leaves some patches of darkened or discolored skin. [sruk.co.uk]

The condition generally lasts several years and then disappears by itself. It may leave scars or areas of darkened or discolored skin. [mayoclinic.org]

In most cases, morphea improves spontaneously over time (typically 3 to 5 years); however, patients are often left with patches of darkened or discolored skin and, in rare [diseaseinfosearch.org]

Cutaneous Amyloidosis

Macular amyloidosis - mild to severely itchy, flat, dusky-brown or greyish colored spots that may come together to form patches of darkened skin. [rarediseases.info.nih.gov]

This rash generally affects the shins, thighs, feet and forearms. [rarediseases.info.nih.gov]

This rash generally appears on the upper back between the shoulder blades, the chest and less commonly, the arms. [rarediseases.info.nih.gov]

Papular Urticaria

These blisters and bumps can vanish and reappear on the skin. Once a blister vanishes, it oftentimes leaves a darkened mark on the skin. [firstaidwinnipeg.ca]

Papular urticaria generally manifests as reddened, itchy bumps or blisters on the skin. The symptoms typically arise in the late spring and summer. [firstaidwinnipeg.ca]

Tropical Phagedenic Ulcer

The distinctive features of a Buruli ulcer include: undermining edges white cotton wool-like appearance thickening and darkening of the skin surrounding the lesion The ulcers [cdc.gov]

[…] are generally painless and progressive; 85% are found on the limbs, with lower limb lesions twice as common as upper limb lesions. [cdc.gov]

Adrenal Gland Disease

CLINICAL MANIFESTATION• General weakness and becoming easily tired.• Darkened areas of skin (pigmentation).• Blood pressure is low and falls further when you stand which can [slideshare.net]

Tuberculosis of the Adrenal Glands

Case 1 A 31-year-old man was admitted in emergency with history of generalized malaise, weakness, fever, vomiting, darkening of skin, and postural giddiness of 1-week duration [esim.eg.net]

Skin showed generalized hyperpigmentation with prominent gingival and buccal mucosa darkening. There was no significant peripheral lymphadenopathy. [panafrican-med-journal.com]

Renal Artery Stenosis

Presentation Signs & Symptoms:  or in urination  edema, usually in the legs, feet, or ankles  drowsiness or tiredness  generalized itching or numbness  dry skin  headaches [slideshare.net]

[…] itching or numbness dry skin headaches weight loss appetite loss nausea vomiting sleep problems trouble concentrating darkened skin muscle cramps What are the possible complications [niddk.nih.gov]

 weight loss  appetite loss  nausea  vomiting  sleep problems  trouble concentrating  darkened skin  muscle cramps  In many cases, RAS has no symptoms until it becomes [slideshare.net]

Metabolic Syndrome

This is darkened skin areas on the back of the neck, in the armpits, and under the breasts. In general, people do not have symptoms. [hopkinsmedicine.org]

Adrenal Insufficiency

[…] or have darkened skin creases, gums and scars. [chop.edu]

Symptoms generally come on slowly and may include abdominal pain, weakness, and weight loss. Darkening of the skin in certain areas may also occur. [apan.rsoewe.com]

Children with adrenal insufficiency may experience: Slow weight gain Fatigue and generalized weakness Low blood pressure Salt cravings They may also appear unusually tanned [chop.edu]

Diffuse Cutaneous Mastocytosis

It does not present as discrete lesions but rather generalized erythema. Pachydermia may also be present, as well as darkening of the skin [ii]. [mastattack.org]

Alopecia Areata

During summer, those same pink spots turn to white spots when the surrounding skin tends to tan or generally darken. Exposure ... [enow.com]

Vitiligo with blue colorations, generally developing in areas of darkened skin following inflammation. Vitiligo ponctué. [nmihi.com]

[…] of this specific fungal infection is the versicolor condition, where in the winter months, when most people aren't in the sun, tinea versicolor most often appears on the skin [enow.com]

Addison Disease

[…] patches of skin. [diabetesselfmanagement.com]

Darkened areas of skin (pigmentation). The cause of this is probably due to the change in hormones which can affect the pigment cells in the skin. [patient.info]

It occurs somewhat more commonly in people with Type 1 diabetes than in the general population. [diabetesselfmanagement.com]

Whipple Disease

[…] symptoms include: Darkening of the skin Chest pain Mild fever Chronic cough Anemia and blood clotting related abnormalities How is Whipple’s Disease Diagnosed? [dovemed.com]

[…] disorder, where bleeding occurs in the back of the eye Pulmonary symptoms: Pleural effusion - accumulation of excess fluid around the lungs Stretching of the mediastinum Other general [dovemed.com]

Biliary Cirrhosis

She also complained of generalized prurigo as well as darkening of her skin, principally of her trunk and forearms, and hypertrichosis of her arms, which had been troubling [scielo.br]

The first and most common symptoms people with this condition experience are a general feeling of tiredness, or fatigue pruritus—itchy skin—and darkened skin in itchy areas [british-liver-trust.org.uk]

Porphyria Cutanea Tarda

In some cases, increased hair growth as well as darkening and thickening of the affected skin may occur. [rarediseases.info.nih.gov]

Showing of 24 | Medical Terms Other Names Learn More: HPO ID 80%-99% of people have these symptoms Abnormal blistering of the skin Blistering, generalized Blisters [ more [rarediseases.info.nih.gov]

Showing of 24 | 80%-99% of people have these symptoms Abnormal blistering of the skin Blistering, generalized Blisters [ more ] 0008066 Cutaneous photosensitivity Photosensitive [rarediseases.info.nih.gov]

Amyloidosis

Macular amyloidosis - mild to severely itchy, flat, dusky-brown or greyish colored spots that may come together to form patches of darkened skin. [rarediseases.info.nih.gov]

This rash generally affects the shins, thighs, feet and forearms. [rarediseases.info.nih.gov]

This rash generally appears on the upper back between the shoulder blades, the chest and less commonly, the arms. [rarediseases.info.nih.gov]

Nitrofurantoin Toxicity

darkening of the urine decreased vision diarrhea diarrhea, watery and severe, which may also be bloody eye pain general tiredness and weakness light-colored stools loss of [drugs.com]

[…] loss of vision, with or without eye pain bulging soft spot on the head of an infant change in the ability to see colors, especially blue or yellow confusion cracks in the skin [drugs.com]

Scrotal Gangrene

Symptoms depend on the site and include fever, pain, darkening of the skin, and an unpleasant odor. [medical-dictionary.thefreedictionary.com]

Signs depend on the site and include fever, pain, darkening of the skin, and an unpleasant odor. [medical-dictionary.thefreedictionary.com]

If the condition involves an internal organ, it is generally attended by pain and collapse. [medical-dictionary.thefreedictionary.com]

Arsenical Keratosis

*Lesions are slightly raised, skin colored or light brown spots that thicken, darken and become wart-like. [ozarkderm.com]

*Cause is unknown, thought to be a part of the general aging process. [ozarkderm.com]

Key Points *Condition consists of common harmless skin lesions that appear during adult life. [ozarkderm.com]

Thrombophlebitis

Sometimes, a thrombophlebitis can leave behind a darkened area on the skin (hyperpigmentation). [marinhealthcare.org]

In general, superficial thrombophlebitis is not dangerous, just painful until it resolves. [marinhealthcare.org]

Elephantiasis

Manifestations of Podoconiosis Early symptoms generally include itching on the forefoot’s skin followed by a burning sensation up to the lower leg. [emedicalhub.com]

The skin of the affected areas usually develops a dry, thickened, pebbly appearance and may become ulcerated, pitted and darkened (hyperkeratosis). [rarediseases.org]

The skin of affected areas usually become pebbly and darkened in appearance and may also be ulcerated. The breasts and genital area are also commonly affected. [emedicalhub.com]