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87 Possible Causes for Generalized Dystonia, Lower Motor Neuron Signs - Later

  • Mitochondrial Membrane Protein-Associated Neurodegeneration

    Conclusions MPAN is characterized by a juvenile‐onset, slowly progressive phenotype with predominant lower limb spasticity, generalized dystonia, and cognitive impairment.[ingentaconnect.com] Early upper motor neuron signs (pyramidal signs, e.g. spasticity) are constant findings and are later followed by signs of lower motor neuron dysfunction (deep tendon reflex[malacards.org] Conclusions MPAN is characterized by a juvenile-onset, slowly progressive phenotype with predominant lower limb spasticity, generalized dystonia, and cognitive impairment.[push-zb.helmholtz-muenchen.de]

  • Neurodegeneration with Brain Iron Accumulation

    […] as great as the benefit reported in patients with primary generalized dystonias or some other secondary dystonias.[ncbi.nlm.nih.gov] Here, we report three C19orf12-mutant patients from two families presenting with predominant upper and lower motor neuron dysfunction mimicking amyotrophic lateral sclerosis[ncbi.nlm.nih.gov] CONCLUSIONS: MPAN is characterized by a juvenile-onset, slowly progressive phenotype with predominant lower limb spasticity, generalized dystonia, and cognitive impairment[ncbi.nlm.nih.gov]

  • Amyotrophic Lateral Sclerosis Type 5

    ALS2 mutations: Juvenile amyotrophic lateral sclerosis and generalized dystonia.[discovery.ucl.ac.uk] AB - Juvenile amyotrophic lateral sclerosis (ALS) is a form of chronic motor neuron disease characterized by combined upper and lower motor neuron symptoms and signs with[jhu.pure.elsevier.com] CONCLUSIONS: We report generalized dystonia and cerebellar signs in association with ALS2-related disease.[foundationdystoniaresearch.org]

  • X-linked Parkinsonism-Spasticity Syndrome

    , segmental region in upper limbs; mild course DYT-14 14q13 Dopa Responsive generalized dystonia Autosomal Dominant Early onset, leading to gait and postural abnormalities[cmdg.org] Lateral sclerosis is the loss of axons in the lateral columns of the spinal cord (the upper motor neurons of the corticospinal tracts).[britannica.com] Dystonia Focal, multifocal, segmental or generalized dystonia Idiopathic, genetic, and secondary dystonia Craniofacial dystonia (including blepharospasm, jaw dystonia, tongue[movementdisorders.us]

  • Juvenile Primary Lateral Sclerosis

    CONCLUSIONS: We report generalized dystonia and cerebellar signs in association with ALS2-related disease.[foundationdystoniaresearch.org] El Escorial criteria for the diagnosis of amyotrophic lateral sclerosis 7 : it requires the presence of signs of lower motor neuron (LMN) degeneration by clinical, electrophysiological[radiopaedia.org] Lower motor neuron loss causes initially increased electrical excitability leading to fasciculations, and later muscle weakness and atrophy; upper motor neuron involvement[neuropathology-web.org]

  • Pallidopyramidal Syndrome

    Epidemiology of focal and generalized dystonia in Rochester, Minnesota. Mov Disord 1988;3:188-194. 9. McCann JD, Gauthier M, Morschbacher R, et al.[flandershealth.us] The patients also showed clinical and electrophysiological signs of upper and/or lower motor neuron degeneration.[karger.com] […] hypotonia Frontotemporal dementia Abnormal lower motor neuron morphology Visual hallucinations Focal dystonia Dyscalculia Motor neuron atrophy Extrapyramidal dyskinesia Milia[mendelian.co]

  • Extrapyramidal Disorder

    In a majority of individuals, dystonia becomes generalized and disabling ( Figure 1B, 1F, 1H ). Progressive dystonia of the trunk may lead to severe dystonic scoliosis.[ncbi.nlm.nih.gov] Clinical phenomena usually consist of a mixture of lower and upper motor neuron signs, dementia, and urinary dysfunction.[jnnp.bmj.com] Lower motor neuron signs are pyramidal not extrapyramidal.[forums.studentdoctor.net]

  • Paraneoplastic Syndrome

    Movement disorders include oro-lingual-facial dyskinesias, generalized chorea, oculogyric crisis, dystonia, and rigidity.[clinlabnavigator.com] […] sclerosis Definition / general: Rarely caused by breast cancer 50% develop lower motor neuron signs eventually Retinal degeneration Definition / general: Destruction of photoreceptors[pathologyoutlines.com] […] anti-Ri autoantibody Peripheral neuropathy Definition / general: Most common paraneoplastic syndrome May be associated with anti-Hu antibody in lung cancer patients Primary lateral[pathologyoutlines.com]

  • Ischemic Peripheral Neuropathy

    Generalized dystonia (e.g., dystonia musculorum deformans) is an inherited condition in which persistent and often painful twisting and writhing movements of any muscle group[britannica.com] Lateral sclerosis is the loss of axons in the lateral columns of the spinal cord (the upper motor neurons of the corticospinal tracts).[britannica.com] ALS, or Lou Gehrig disease, is characterized by muscle wasting due to loss of the ventral-horn cells (the lower motor neurons).[britannica.com]

  • Spinal Demyelination

    Generalized dystonia (e.g., dystonia musculorum deformans) is an inherited condition in which persistent and often painful twisting and writhing movements of any muscle group[britannica.com] Lateral sclerosis is the loss of axons in the lateral columns of the spinal cord (the upper motor neurons of the corticospinal tracts).[britannica.com] ALS, or Lou Gehrig disease, is characterized by muscle wasting due to loss of the ventral-horn cells (the lower motor neurons).[britannica.com]

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