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87 Possible Causes for Generalized Dystonia, Lower Motor Neuron Signs - Later, Weakness

  • Mitochondrial Membrane Protein-Associated Neurodegeneration

    Conclusions MPAN is characterized by a juvenile‐onset, slowly progressive phenotype with predominant lower limb spasticity, generalized dystonia, and cognitive impairment.[] Early upper motor neuron signs (pyramidal signs, e.g. spasticity) are constant findings and are later followed by signs of lower motor neuron dysfunction (deep tendon reflex[] The patient presented at four years of age with progressive lower extremity weakness and generalized hypotonia.[]

  • Amyotrophic Lateral Sclerosis Type 5

    ALS2 mutations: Juvenile amyotrophic lateral sclerosis and generalized dystonia.[] AB - Juvenile amyotrophic lateral sclerosis (ALS) is a form of chronic motor neuron disease characterized by combined upper and lower motor neuron symptoms and signs with[] ALS5 patients suffer from slowly progressive muscle weakness beginning in their limbs and spreading to the bulbar muscles.[]

  • Juvenile Primary Lateral Sclerosis

    CONCLUSIONS: We report generalized dystonia and cerebellar signs in association with ALS2-related disease.[] El Escorial criteria for the diagnosis of amyotrophic lateral sclerosis 7 : it requires the presence of signs of lower motor neuron (LMN) degeneration by clinical, electrophysiological[] They include: Stiffness, weakness and spasticity in your legs Tripping, difficulty with balance and clumsiness as the leg muscles weaken Weakness and stiffness progressing[]

  • Amyotrophic Lateral Sclerosis

    It can be localized to a certain group of muscles or can be generalized (180).[] It is one of many motor neuron diseases, but what makes it stand out is that it presents with both upper and lower motor neuron signs.[] In 1990, a 58-year-old man noted weakness in the hands.[]

  • X-linked Parkinsonism-Spasticity Syndrome

    , segmental region in upper limbs; mild course DYT-14 14q13 Dopa Responsive generalized dystonia Autosomal Dominant Early onset, leading to gait and postural abnormalities[] Lateral sclerosis is the loss of axons in the lateral columns of the spinal cord (the upper motor neurons of the corticospinal tracts).[] Although the disorder is typically referred to as hereditary spastic paraplegia the degree of weakness is variable and ranges from no weakness (full strength) to marked weakness[]

  • Autosomal Recessive Spastic Paraplegia Type 49

    ALS2 mutations: juvenile amyotrophic lateral sclerosis and generalized dystonia. Neurology 2014;82(12):1065-7.[] Familial Amyotrophic Lateral Sclerosis (SOD1 Mutation) Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease involving both the upper motor neurons[] Although the disorder is typically referred to as hereditary spastic paraplegia the degree of weakness is variable and ranges from no weakness (full strength) to marked weakness[]

  • Young Adult-Onset Distal Hereditary Motor Neuropathy

    […] limb-onset dystonia Fructose-1,6-bisphosphatase deficiency Glycogen storage disease due to lactate dehydrogenase H-subunit deficiency Hypohidrotic ectodermal dysplasia with[] Most patients have clinical signs of both upper and lower motor neuron disease and are diagnosed with amyotrophic lateral sclerosis - ALS.[] […] patients with marked weakness are able to walk.[]

  • Spinal Demyelination

    Generalized dystonia (e.g., dystonia musculorum deformans) is an inherited condition in which persistent and often painful twisting and writhing movements of any muscle group[] The strengths and weaknesses of all these techniques in the study of multiple sclerosis and other relevant diseases are extensively considered.[] Neurological examination showed weakness (4/5) in his lower limbs. Deep and superficial sensitivity were decreased below T10.[]

  • Distal Hereditary Motor Neuropathy Type 1

    […] bulbospinal muscular atrophy Generalized epilepsy with febrile seizures-plus Generalized epilepsy-paroxysmal dyskinesia syndrome Generalized isolated dystonia Genetic central[] neuron disorders presenting with variable combination of upper and lower motor neuron signs.[] They developed mild symmetrical distal lower limb weakness, muscle wasting, and severe foot… CONTINUE READING[]

  • X-linked Distal Spinal Muscular Atrophy Type 3

    [primary TOR1A (DYT1)] G31.82 Leigh's disease G40.301 - G40.319 Generalized idiopathic epilepsy and epileptic syndromes [nonspecific myoclonic epileptic seizures (MERRF)[] Some questions your doctor may ask you: when was the weakness first noted? what has the progression been? is there any family history of people with similar weakness?[] […] of distal muscles of hands and feet with normal deep tendon reflexes or absent ankle reflexes and minimal or no sensory loss, sometimes mild proximal weakness in the legs[]

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