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20 Possible Causes for Generalized Lymphadenopathy, Globulins Increased, Virus Associated Hemophagocytic Syndrome

  • Infectious Mononucleosis

    lymphadenopathy, including cervical lymphadenopathy tonsillar enlargement possible hepatomegaly Treatment and prognosis Symptomatic therapy is usually sufficient.[radiopaedia.org] , gamma globulin increased less frequently, and beta globulin, which was normal in practically all the cases of infectious mononucleosis, was increased in a considerable number[link.springer.com] Severe chronic active Epstein-Barr virus infection accompanied by virus-associated hemophagocytic syndrome, cerebellar ataxia and encephalitis.[emedicine.medscape.com]

  • Lymphoma

    When more than one area of lymph nodes is swollen it’s called generalized lymphadenopathy.[m.cancer.org] The erythrocyte sedimentation rate is a sign of activity of the disease and is caused by the increase of the a2-globulins and of the gamma globulins.[lecturio.com] Hodgkin lymphoma-associated hemophagocytic syndrome: a disorder strongly correlated with Epstein-Barr virus. Clin Infect Dis. 2008 Aug 15. 47(4):531-4. [Medline].[emedicine.medscape.com]

  • Hepatitis A

    Signs include hepatomegaly, lymphadenopathy and splenomegaly, though these findings vary from individual to individual, depending on general health status and age group.[symptoma.com] , which can help increase protection to HAV.[liverfoundation.org] hemophagocytic syndrome [3].[ncbi.nlm.nih.gov]

  • Hodgkin Lymphoma

    A day later he developed the generalized rash of acute varicella infection. This was managed with valacyclovir.[ncbi.nlm.nih.gov] Hodgkin lymphoma-associated hemophagocytic syndrome: a disorder strongly correlated with Epstein-Barr virus. Clin Infect Dis. 2008 Aug 15. 47(4):531-4. [Medline].[emedicine.medscape.com] His F-18 FDG PET/CT, performed to exclude lymphoma recurrence, demonstrated FDG-avid lymphadenopathy and increased FDG uptake in his spleen.[ncbi.nlm.nih.gov]

  • Precursor-Cell Lymphoblastic Leukemia

    Late-onset fatal Epstein-Barr virusassociated hemophagocytic syndrome following cord blood cell transplantation for adult acute lymphoblastic leukemia .[ajcp.oxfordjournals.org] Epstein-Barr virus associated hemophagocytic lymphohystiocytosis during maintenance treatment of acute lymphoblastic leukemia .[ajcp.oxfordjournals.org]

  • Chronic Active Hepatitis B

    GIANOTTI SYNDROME (Infantile papular acrodermatitis):Papular skin eruptions with generalized lymphadenopathy in children under eight years.[meddean.luc.edu] In all patients AST and ALT values returned to normal and there was a fall in serum delta GT and improvement of prothrombin time. an increase of globulins was noted.[ncbi.nlm.nih.gov] Bone marrow biopsy showed hypocellularity, histiocytic hyperplasia, and hemophagocytosis consistent with a virus-associated hemophagocytic syndrome (VAHS).[ncbi.nlm.nih.gov]

  • Autoimmune Hepatitis

    We report the case of a woman who developed DRESS syndrome with a generalized maculopapular rash, eosinophilia, dyspnea, bilateral cervical lymphadenopathy, and reactivation[ncbi.nlm.nih.gov] More than 80% of affected individuals have increased gamma globulin in the blood.[hepatitiscentral.com] Virus-, drug- and lymphoma-associated hemophagocytic syndrome (HPS) was ruled out. Therefore, the patient was diagnosed with autoimmune-associated HPS (AAHS).[ncbi.nlm.nih.gov]

  • Dengue Fever

    The fever generally lasts for 2-7 days and so fever longer than 10 days may not be due to dengue.[symptoma.com] globulin ( De Castro et al., 2007 ).[ncbi.nlm.nih.gov] ’s records revealed that she met the clinical case definition for hemophagocytic lymphohistiocytosis, a hyperinflammatory syndrome that is sometimes associated with dengue[emedicine.com]

  • Lymphadenitis

    Citation Lansky C, Sheikh H, Lazkani M, O’Malley C (2016) Kikuchi-Fujimoto Necrotizing Lymphadenitis: A rare case of generalized lymphadenopathy.[oatext.com] Serum albumin falls and gamma globulins increase. • An X-ray chest is mandatory for coexisting pulmonary lesion. • Positive FNAC and biopsy are essential for confirming diagnosis[de.slideshare.net] We describe a fatal case of drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome with human herpesvirus-6B (HHV-6B)-associated lymphadenitis and virus-associated[ncbi.nlm.nih.gov]

  • Exfoliative Dermatitis

    Over the next four days the eruption worsened into erythroderma with fever and generalized lymphadenopathy.[ncbi.nlm.nih.gov] Immune responses may be altered, as evidenced by increased gamma-globulins, increased serum IgE in some cases, eosinophil infiltration, and CD4 T-cell lymphocytopenia in the[emedicine.medscape.com] 75 Monoclonal gammopathy of undetermined significance 76 Hemophagocytic histiocytosis, viral associated 78 , 79 Bacterial Tuberculosis 52 Congenital syphilis 57 Viral Hepatitis[plasticsurgerykey.com]

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