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20 Possible Causes for Generalized Lymphadenopathy, Globulins Increased, Virus Associated Hemophagocytic Syndrome

  • Infectious Mononucleosis

    lymphadenopathy, including cervical lymphadenopathy tonsillar enlargement possible hepatomegaly Treatment and prognosis Symptomatic therapy is usually sufficient.[] , gamma globulin increased less frequently, and beta globulin, which was normal in practically all the cases of infectious mononucleosis, was increased in a considerable number[] Severe chronic active Epstein-Barr virus infection accompanied by virus-associated hemophagocytic syndrome, cerebellar ataxia and encephalitis.[]

  • Lymphoma

    When more than one area of lymph nodes is swollen it’s called generalized lymphadenopathy.[] The erythrocyte sedimentation rate is a sign of activity of the disease and is caused by the increase of the a2-globulins and of the gamma globulins.[] Hodgkin lymphoma-associated hemophagocytic syndrome: a disorder strongly correlated with Epstein-Barr virus. Clin Infect Dis. 2008 Aug 15. 47(4):531-4. [Medline].[]

  • Hepatitis A

    Signs include hepatomegaly, lymphadenopathy and splenomegaly, though these findings vary from individual to individual, depending on general health status and age group.[] , which can help increase protection to HAV.[] hemophagocytic syndrome [3].[]

  • Hodgkin Lymphoma

    A day later he developed the generalized rash of acute varicella infection. This was managed with valacyclovir.[] Hodgkin lymphoma-associated hemophagocytic syndrome: a disorder strongly correlated with Epstein-Barr virus. Clin Infect Dis. 2008 Aug 15. 47(4):531-4. [Medline].[] His F-18 FDG PET/CT, performed to exclude lymphoma recurrence, demonstrated FDG-avid lymphadenopathy and increased FDG uptake in his spleen.[]

  • Precursor-Cell Lymphoblastic Leukemia

    Late-onset fatal Epstein-Barr virusassociated hemophagocytic syndrome following cord blood cell transplantation for adult acute lymphoblastic leukemia .[] Epstein-Barr virus associated hemophagocytic lymphohystiocytosis during maintenance treatment of acute lymphoblastic leukemia .[]

  • Chronic Active Hepatitis B

    GIANOTTI SYNDROME (Infantile papular acrodermatitis):Papular skin eruptions with generalized lymphadenopathy in children under eight years.[] In all patients AST and ALT values returned to normal and there was a fall in serum delta GT and improvement of prothrombin time. an increase of globulins was noted.[] Bone marrow biopsy showed hypocellularity, histiocytic hyperplasia, and hemophagocytosis consistent with a virus-associated hemophagocytic syndrome (VAHS).[]

  • Autoimmune Hepatitis

    We report the case of a woman who developed DRESS syndrome with a generalized maculopapular rash, eosinophilia, dyspnea, bilateral cervical lymphadenopathy, and reactivation[] More than 80% of affected individuals have increased gamma globulin in the blood.[] Virus-, drug- and lymphoma-associated hemophagocytic syndrome (HPS) was ruled out. Therefore, the patient was diagnosed with autoimmune-associated HPS (AAHS).[]

  • Dengue Fever

    The fever generally lasts for 2-7 days and so fever longer than 10 days may not be due to dengue.[] globulin ( De Castro et al., 2007 ).[] ’s records revealed that she met the clinical case definition for hemophagocytic lymphohistiocytosis, a hyperinflammatory syndrome that is sometimes associated with dengue[]

  • Lymphadenitis

    Citation Lansky C, Sheikh H, Lazkani M, O’Malley C (2016) Kikuchi-Fujimoto Necrotizing Lymphadenitis: A rare case of generalized lymphadenopathy.[] Serum albumin falls and gamma globulins increase. • An X-ray chest is mandatory for coexisting pulmonary lesion. • Positive FNAC and biopsy are essential for confirming diagnosis[] We describe a fatal case of drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome with human herpesvirus-6B (HHV-6B)-associated lymphadenitis and virus-associated[]

  • Exfoliative Dermatitis

    Over the next four days the eruption worsened into erythroderma with fever and generalized lymphadenopathy.[] Immune responses may be altered, as evidenced by increased gamma-globulins, increased serum IgE in some cases, eosinophil infiltration, and CD4 T-cell lymphocytopenia in the[] 75 Monoclonal gammopathy of undetermined significance 76 Hemophagocytic histiocytosis, viral associated 78 , 79 Bacterial Tuberculosis 52 Congenital syphilis 57 Viral Hepatitis[]

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