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684 Possible Causes for Generalized Lymphadenopathy, Hepatosplenomegaly

  • Infectious Mononucleosis

    There is an increase in mononuclear white blood cells and other atypical lymphocytes, generalized lymphadenopathy, splenomegaly, and occasionally hepatomegaly with hepatitis[] Both cases involved young adults presenting with fever, pharyngitis, lymphadenopathy, hepatosplenomegaly, and atypical lymphocytosis confirmed by serologic tests, liver biopsy[] IM is generally a self-limiting disease with symptoms resolving in a few weeks.[]

  • Pharyngitis

    Unlike strep throat, however, infectious mononucleosis can be associated with generalized lymphadenopathy.[] Presence of hepatosplenomegaly or lymphadenopathy outside the cervical region should raise suspicions regarding an underlying malignancy.[] When streptococcal pharyngitis is suspected, the physician should listen for the presence of a heart murmur and evaluate the patient for hepatosplenomegaly.[]

  • Chagas Disease

    Symptoms after a Triatominae bite typically begin with a skin lesion or unilateral periorbital edema, then progress to fever, malaise, generalized lymphadenopathy, and hepatosplenomegaly[] Read more Symptoms The disease has two clinical stages: – Acute (in which 5% of children die) characterized by fever, malaise, facial oedema, generalized lymphadenopathy,[] generalized oedema diarrhoea multiple lymphadenopathy myocarditis (chest pain, heart failure) more rarely meningoencephalitis (seizures, paralysis) Chronic phase The chronic[]

  • Langerhans-Cell Histiocytosis

    A 2-year-old boy presented with generalized lymphadenopathy, fever, and cough. The patient had hepatosplenomegaly, anemia, and lytic lesions in the skull.[] He also had hepatosplenomegaly and pulmonary involvement.[] There was no evidence of lymph node enlargement or hepatosplenomegaly. Peripheral blood film showed microcytic hypochromic anemia. Haemoglobin was 9.5gm/dl.[]

  • Angioimmunoblastic Lymphadenopathy

    A 55-year-old Japanese man presented with red papular lesions on the trunk and limbs, oedema, and generalized lymphadenopathy.[] AILD is characterized by generalized lymphadenopathy, hepatosplenomegaly, immunological abnormalities, polyclonal hypergammaglobulinemia and anemia.[] Although complete remission of AML was achieved, fever persisted and atypical skin rash followed by generalized lymphadenopathy along with polyclonal hypergammaglobulinemia[]

  • Malignant Histiocytosis

    All had localized or generalized lymphadenopathy and three had hepatosplenomegaly at initial presentation.[] A 70-year-old woman was admitted for evaluation of hepatosplenomegaly, fever and elevated serum LDH levels.[] lymphadenopathy and pancytopenia.[]

  • African Trypanosomiasis

    Symptoms include characteristic skin lesions, intermittent fever, headache, rigors, transient edema, generalized lymphadenopathy, and often fatal meningoencephalitis.[] Abdominal and pelvic MRI showed hepatosplenomegaly and multiple enlarged lymph nodes.[] […] of 41ºC, preceded by chills, bleeding from the gums and oral mucosa, haemorrhages at the sites of venipuncture, numerous ecchymoses, fine-spotted skin rash, tachycardia, hepatosplenomegaly[]

  • Typhus

    Scrub typhus is an acute infectious disease caused by Orienta tsutsugamushi, which is clinically manifested by fever, generalized lymphadenopathy, diffuse myalgia, headache[] Other patients go on to develop a more serious disease, in which encephalitis, pneumonia, and swelling of the liver and spleen (hepatosplenomegaly) occur.[] Localized lymphadenopathy is noted at the site of bite and this may develop into generalized lymphadenopathy.[]

  • Congenital Syphilis

    These neonates also display significant changes in bone morphology and frequently hepatosplenomegaly along with generalized lymphadenopathy.[] A previously healthy male infant developed hepatosplenomegaly, severe anaemia and thrombocytopenia 5 weeks after birth.[] The various signs associated with early CS are listed below: General symptoms The general symptoms include: Fever Failure to thrive Generalized lymphadenopathy Intrauterine[]

  • T-Cell Lymphoma

    A 64-year-old woman presented with generalized lymphadenopathy and systemic manifestations.[] Hepatosplenomegaly and systemic lymphadenopathy were detected by enhanced computed tomography.[] He developed graft-versus-host disease with skin and gastrointestinal involvement and generalized lymphadenopathy 4 months after transplantation.[]

Further symptoms

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