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175 Possible Causes for Generalized Lymphadenopathy, Hypercellular Bone Marrow

  • Leukemia

    Dogs are usually seen with generalized, rapidly progressive lymphadenopathy.[ncbi.nlm.nih.gov] Bone marrow aspirate showed hypercellularity with increased myelopoiesis and markedly suppressed megakaryopoiesis giving an impression of acute myeloid leukemia and was confirmed[ncbi.nlm.nih.gov] Another important feature of bone marrow samples is its cellularity. Normal bone marrow contains hematopoietic (blood-forming) cells and fat cells.[web.archive.org]

  • Autoimmune Hemolytic Anemia

    lymphadenopathy, splenomegaly and mild hepatitis.[ncbi.nlm.nih.gov] Subsequently, the patient underwent a bone marrow biopsy that showed a hypercellular marrow with erythroid hyperplasia, but no evidence of dysplasia or lymphoma.[jmedicalcasereports.com] She was found to have splenomegaly, generalized lymphadenopathy, pancytopenia, and acute hepatic failure.[ncbi.nlm.nih.gov]

  • Myeloproliferative Disease

    The chronic myeloproliferative diseases are characterized by relatively effective hematopoiesis, which results in a hypercellular bone marrow and elevation of one or more[clinlabnavigator.com] Bone marrow histology shows hypercellularity in most of these disorders. In the case of myelofibrosis, bone marrow fibrosis is demonstrated on the reticulin stain.[emedicine.com] This is in contrast to the myelodysplastic syndromes, in which the bone marrow is hypercellular, but the production is ineffective in one or more cell lines, resulting in[clinlabnavigator.com]

  • Acute Leukemia

    Some individuals with ALL and AML may develop localized or generalized lymphadenopathy, or even shortness of breath as a result of enlarged mediastinal nodes.[symptoma.com] ALL : Hypercellular bone marrow Numerous tightly packed lymphoblasts with undetectable cytoplasm, round, irregular, cleaved nuclei, dispersed chromatin, small nucleoli B[pathologyoutlines.com] General treatment for ALL is broken down into the following 4 phases: 1.[physio-pedia.com]

  • Chronic Myeloid Leukemia

    marrow biopsy: Moderately hypercellular bone marrow biopsy with numerous megakaryocytes Increased reticulin fibers (reticulin stain) Marked hypercellularity Myeloblastic[pathologyoutlines.com] Because of such abnormal shapes, these cells are destroyed before releasing into the peripheral blood circulation, leading to cytopenias and hypercellular bone marrow.[lecturio.com] marrow hypercellularity, granulocyte proliferation, and decrease in erythroid precursors.[doi.org]

  • Chronic Phase of Chronic Myeloid Leukemia

    marrow biopsy: Moderately hypercellular bone marrow biopsy with numerous megakaryocytes Increased reticulin fibers (reticulin stain) Marked hypercellularity Myeloblastic[pathologyoutlines.com] A bone marrow biopsy and aspiration demonstrated a hypercellular marrow with no other significant morphologic abnormalities.[hematologyandoncology.net] marrow Early myeloid cells (eg, myeloblasts, myelocytes, metamyelocytes, nucleated red blood cells) Bone marrow findings Ph chromosome (a reciprocal translocation of chromosomal[emedicine.medscape.com]

  • Infectious Mononucleosis

    lymphadenopathy, including cervical lymphadenopathy tonsillar enlargement possible hepatomegaly Treatment and prognosis Symptomatic therapy is usually sufficient.[radiopaedia.org] A bone marrow aspirate ruled out haemophagocytic syndrome.[ncbi.nlm.nih.gov] There is an increase in mononuclear white blood cells and other atypical lymphocytes, generalized lymphadenopathy, splenomegaly, and occasionally hepatomegaly with hepatitis[fpnotebook.com]

  • Drug Hypersensitivity

    Howard Libman, Generalized lymphadenopathy, Journal of General Internal Medicine, 10.1007/BF02596251, 2, 1, (48-58), (1987). M. J.[doi.org] As for the cases of bone marrow biopsy, 5 of the 6 showed hypocellularity with a decrease in both myeloid and erythroid series, and 1 showed hypercellularity and an increased[doi.org] […] diagnosed as EM 2 (12%)—only perivascular inflammation by mixed cells 1 (6%)—lymphocytic vasculitis 1 (6%)—pigment incontinence without obvious interface activity 6 underwent bone-marrow[ncbi.nlm.nih.gov]

  • Chronic Myelomonocytic Leukemia

    CMML is generally diagnosed in the elderly, but the clinical presentation of affected individuals varies largely.[symptoma.com] marrow biopsy: Markedly hypercellular marrow Bone marrow smear: Increased monocytes and monocyte precursors Increase in monocyte precursors and erythroid cytoplasmic vacuoles[pathologyoutlines.com] Histopathology The bone marrow is hypercellular with significant granulocytic proliferation.[e-immunohistochemistry.info]

  • Acute Myelocytic Leukemia

    On exam, he has bilateral submandibular lymphadenopathy and hepatosplenomegaly. CBC demonstrates decreased RBCs and mature WBCs.[step1.medbullets.com] The presence of “dry tap” indicates the presence of extensive fibrosis or hypercellular bone marrow.[lecturio.com] marrow biopsy: Markedly hypercellular marrow with heterogeneous cells, including immature monocytes (irregular nuclei and prominent nucleoli) and neutrophils Stains: Chloroacetate[pathologyoutlines.com]

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