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175 Possible Causes for Generalized Lymphadenopathy, Hypercellular Bone Marrow

  • Leukemia

    Dogs are usually seen with generalized, rapidly progressive lymphadenopathy.[] Bone marrow aspirate showed hypercellularity with increased myelopoiesis and markedly suppressed megakaryopoiesis giving an impression of acute myeloid leukemia and was confirmed[] Another important feature of bone marrow samples is its cellularity. Normal bone marrow contains hematopoietic (blood-forming) cells and fat cells.[]

  • Autoimmune Hemolytic Anemia

    lymphadenopathy, splenomegaly and mild hepatitis.[] Subsequently, the patient underwent a bone marrow biopsy that showed a hypercellular marrow with erythroid hyperplasia, but no evidence of dysplasia or lymphoma.[] She was found to have splenomegaly, generalized lymphadenopathy, pancytopenia, and acute hepatic failure.[]

  • Myeloproliferative Disease

    The chronic myeloproliferative diseases are characterized by relatively effective hematopoiesis, which results in a hypercellular bone marrow and elevation of one or more[] Bone marrow histology shows hypercellularity in most of these disorders. In the case of myelofibrosis, bone marrow fibrosis is demonstrated on the reticulin stain.[] This is in contrast to the myelodysplastic syndromes, in which the bone marrow is hypercellular, but the production is ineffective in one or more cell lines, resulting in[]

  • Acute Leukemia

    Some individuals with ALL and AML may develop localized or generalized lymphadenopathy, or even shortness of breath as a result of enlarged mediastinal nodes.[] ALL : Hypercellular bone marrow Numerous tightly packed lymphoblasts with undetectable cytoplasm, round, irregular, cleaved nuclei, dispersed chromatin, small nucleoli B[] General treatment for ALL is broken down into the following 4 phases: 1.[]

  • Chronic Myeloid Leukemia

    marrow biopsy: Moderately hypercellular bone marrow biopsy with numerous megakaryocytes Increased reticulin fibers (reticulin stain) Marked hypercellularity Myeloblastic[] Because of such abnormal shapes, these cells are destroyed before releasing into the peripheral blood circulation, leading to cytopenias and hypercellular bone marrow.[] marrow hypercellularity, granulocyte proliferation, and decrease in erythroid precursors.[]

  • Chronic Phase of Chronic Myeloid Leukemia

    marrow biopsy: Moderately hypercellular bone marrow biopsy with numerous megakaryocytes Increased reticulin fibers (reticulin stain) Marked hypercellularity Myeloblastic[] A bone marrow biopsy and aspiration demonstrated a hypercellular marrow with no other significant morphologic abnormalities.[] marrow Early myeloid cells (eg, myeloblasts, myelocytes, metamyelocytes, nucleated red blood cells) Bone marrow findings Ph chromosome (a reciprocal translocation of chromosomal[]

  • Infectious Mononucleosis

    lymphadenopathy, including cervical lymphadenopathy tonsillar enlargement possible hepatomegaly Treatment and prognosis Symptomatic therapy is usually sufficient.[] A bone marrow aspirate ruled out haemophagocytic syndrome.[] There is an increase in mononuclear white blood cells and other atypical lymphocytes, generalized lymphadenopathy, splenomegaly, and occasionally hepatomegaly with hepatitis[]

  • Drug Hypersensitivity

    Howard Libman, Generalized lymphadenopathy, Journal of General Internal Medicine, 10.1007/BF02596251, 2, 1, (48-58), (1987). M. J.[] As for the cases of bone marrow biopsy, 5 of the 6 showed hypocellularity with a decrease in both myeloid and erythroid series, and 1 showed hypercellularity and an increased[] […] diagnosed as EM 2 (12%)—only perivascular inflammation by mixed cells 1 (6%)—lymphocytic vasculitis 1 (6%)—pigment incontinence without obvious interface activity 6 underwent bone-marrow[]

  • Chronic Myelomonocytic Leukemia

    CMML is generally diagnosed in the elderly, but the clinical presentation of affected individuals varies largely.[] marrow biopsy: Markedly hypercellular marrow Bone marrow smear: Increased monocytes and monocyte precursors Increase in monocyte precursors and erythroid cytoplasmic vacuoles[] Histopathology The bone marrow is hypercellular with significant granulocytic proliferation.[]

  • Acute Myelocytic Leukemia

    On exam, he has bilateral submandibular lymphadenopathy and hepatosplenomegaly. CBC demonstrates decreased RBCs and mature WBCs.[] The presence of “dry tap” indicates the presence of extensive fibrosis or hypercellular bone marrow.[] marrow biopsy: Markedly hypercellular marrow with heterogeneous cells, including immature monocytes (irregular nuclei and prominent nucleoli) and neutrophils Stains: Chloroacetate[]

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