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194 Possible Causes for Generalized Lymphadenopathy, Lactate Dehydrogenase Increased

  • Infectious Mononucleosis

    There is an increase in mononuclear white blood cells and other atypical lymphocytes, generalized lymphadenopathy, splenomegaly, and occasionally hepatomegaly with hepatitis[] IM is generally a self-limiting disease with symptoms resolving in a few weeks.[] Classic physical findings include fever, splenomegaly, pharyngitis, and lymphadenopathy. Treatment for infectious mononucleosis is generally supportive.[]

  • Angioimmunoblastic Lymphadenopathy

    A 55-year-old Japanese man presented with red papular lesions on the trunk and limbs, oedema, and generalized lymphadenopathy.[] dehydrogenase (LDH) level (commonly increased) Polyclonal gamma globulins (common) Anemia with hemoglobin with values below 10 g/dL can be present, and a direct Coombs test[] Although complete remission of AML was achieved, fever persisted and atypical skin rash followed by generalized lymphadenopathy along with polyclonal hypergammaglobulinemia[]

  • Systemic Lupus Erythematosus

    Systemic lupus erythematosus with an unusual presentation of generalized lymphadenopathy was diagnosed in both patients.[]

  • Acute Lymphoblastic Leukemia

    Serum level of lactate dehydrogenase (LDH) predicts increased anaerobic glycolysis and is associated with metabolic modulation in cancer cells.[]

  • Multiple Myeloma

    A 75-year-old male presented with generalized erythematous, scaly plaques and painless lymphadenopathy.[] This report highlights the dermatological manifestations of Rosai-Dorfman disease with generalized painless lymphadenopathy.[]

  • Autoimmune Hemolytic Anemia

    She was found to have splenomegaly, generalized lymphadenopathy, pancytopenia, and acute hepatic failure.[] Unconjugated bilirubin is usually, but not always, elevated and urine urobilinogen is increased. Lactate dehydrogenase is usually elevated into the thousands.[] Abdomen was soft, lax with generalized tenderness and no hepatosplenomegaly. Apart from small right axillary lymph node, no lymphadenopathy could be detected clinically.[]

  • Lassa Fever

    Although she was afebrile, generalized lymphadenopathy was still present, and a chest radiograph showed left-sided pleural effusion.[] High serum aspartate aminotransferase and lactate dehydrogenase (LDH) levels were remarkable in both patients.[] Viremia increased steadily and reached a plateau of approximately 10(8)-10(9) copies/ml 4 days before death, while IFN-gamma and TNF-alpha rose to extremely high levels only[]

  • T-Cell Lymphoma

    A 64-year-old woman presented with generalized lymphadenopathy and systemic manifestations.[] He developed graft-versus-host disease with skin and gastrointestinal involvement and generalized lymphadenopathy 4 months after transplantation.[] Most patients present with generalized lymphadenopathy, hepatosplenomegaly, skin rash and general symptoms (fever, weight loss).[]

  • Multicentric Castleman's Disease

    Multicentric Castleman's disease (MCD) is a rare disorder characterized by fever, polyclonal hypergammaglobulinemia, and generalized lymphadenopathy.[] Multicentric Castleman's Disease (MCD) is a systemic disease characterized by generalized lymphadenopathy and the proliferation of plasma cells.[] It is typically accompanied by generalized lymphadenopathy and multiorgan involvement.[]

  • Mantle Cell Lymphoma

    Fatigue, generalized lymphadenopathy and splenomegaly are its typical features.[] lymphadenopathies in 90%, bone marrow involvement (70%), frequent splenomegaly (50%), hepatomegaly (30%), and gastro-intestinal involvement (20%), and lymphocytosis (30%)[] Patients with MCL typically present with generalized lymphadenopathy and extranodal involvement, particularly in the bone marrow, spleen, and gastrointestinal tract.[]

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