Generalized Muscle Weakness: Causes & Reasons

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Possible Causes for Generalized Muscle Weakness

Conn Syndrome

muscle weakness. [medbullets.com]

Other symptoms can include hypokalemia (low blood potassium level), headache and muscle weakness. [uwhealth.org]

[…] see Preferred Response PREFERRED RESPONSE 2 Sorry, this question is for PEAK Premium Subscribers only (M1.EC.42) A 47-year-old male presents with a primary complaint of generalized [medbullets.com]

Singleton Merten Syndrome

Generalized muscle weakness Muscle atrophy Treatment Treatment is typically directed toward the specific symptoms that are present in each individual. [wikidoc.org]

Additional features included generalized muscle weakness and atrophy, and chronic psoriasiform skin eruptions. [orpha.net]

Skin conditions Malformation of the hips and/or feet Growth delay Delays in motor development Diagnosis Symptoms Generalized muscle weakness Physical Examination Extremities [wikidoc.org]

Congenital Myopathy with Excess of Thin Filaments

muscle weakness. [malacards.org]

muscle weakness, waddling gait and facial paresis. [malacards.org]

[…] excitation-contraction coupling Congenital Myopathy Severity of presentation varies w/ age Generalized hypotonic w/ particular weakness in bulbar neck and respiratory muscles [quizlet.com]

Rigid Spine Syndrome

Diseases related with Edema and Generalized muscle weakness In the following list you will find some of the most common rare diseases related to Edema and Generalized muscle [mendelian.co]

0001371 Generalized amyotrophy Diffuse skeletal muscle wasting Generalized muscle degeneration Muscle atrophy, generalized [ more ] 0003700 Generalized muscle weakness 0003324 [rarediseases.info.nih.gov]

This form of the condition also causes general muscle weakness and feeding difficulties that appear in the first year of life. [ghr.nlm.nih.gov]

Multicore Myopathy with External Ophthalmoplegia

weakness ; Decreased fetal movement ; Difficulty running ; Exercise-induced myalgia ; External ophthalmoplegia ; Facial palsy ; Feeding difficulties in infancy ; Generalized [mousephenotype.org]

Learn more about how to achieve it with Mendelian Learn more Other signs and symptoms that you may find interesting Autoimmunity and Generalized muscle weakness, related diseases [mendelian.co]

Generalized muscle weakness 0003324 Hydrops fetalis 0001789 Muscular hypotonia Low or weak muscle tone 0001252 Neonatal hypotonia Low muscle tone, in neonatal onset 0001319 [rarediseases.info.nih.gov]

Nemaline Myopathy

In the patient with the severe infantile form, respiratory failure paralleled the generalized muscle weakness, whereas the 3 patients with the benign infantile form suddenly [ncbi.nlm.nih.gov]

Nemaline myopathy is a common form of congenital myopathy manifesting with nonprogressive generalized muscle weakness, hypotonia, and electron-dense protein inclusions in [ncbi.nlm.nih.gov]

The severity and pattern of muscle weakness varies, but most affected individuals show mildly delayed motor development, hypotonia, generalized muscle weakness, and weakness [diseaseinfosearch.org]

Congenital Fiber-Type Disproportion Myopathy

[…] bulbar muscles ; Flexion contracture of finger ; Generalized muscle weakness ; High palate ; Hip contracture ; Hyperlordosis ; Intellectual disability ; Joint laxity ; Knee [beta.mousephenotype.org]

muscle weakness. [invitae.com]

Symptoms - Congenital fiber type disproportion Major symptoms may include loss of muscle tone (hypotonia) and generalized muscle weakness. [checkorphan.org]

Distal Spinal Muscular Atrophy Type 4

Based on the pattern of weakness, we identified three groups: 13 patients with generalized weakness (group 1); eight patients with symmetrical, distal muscle weakness (group [academic.oup.com]

Presentation Spinal muscular atrophy (SMA) generally presents with muscle weakness and wasting. The limbs, respiratory and bulbar muscles and brainstem can be affected. [patient.info]

The clinical phenotype can include congenital hypotonia, generalized muscle weakness, delayed motor milestones, feeding difficulties, and facial muscle involvement. [mayomedicallaboratories.com]

Myasthenia Gravis

Some patients develop generalized muscle weakness, which may become serious with respiratory muscle weakness. [orpha.net]

In the juvenile form, onset is before 18 years of age (juvenile myasthenia gravis; see this term) and patients also present with ocular and possibly generalized muscle weakness [orpha.net]

Patients have fluctuating weakness, worsening with repetitive activities, heat and stress while improving with rest and with involvement of skeletal muscle groups of ocular [orpha.net]

Miller-Fisher Syndrome

Additional symptoms include generalized muscle weakness and respiratory failure. [ninds.nih.gov]

It is characterized by abnormal muscle coordination, paralysis of the eye muscles, and absence of the tendon reflexes. [ninds.nih.gov]

X-linked Distal Spinal Muscular Atrophy Type 3

Symptoms of this condition may include: General muscle weakness Trembling Twitching Minor difficulty breathing Because X-linked spinal muscular atrophy is carried on the X [cedars-sinai.edu]

The disease is caused by a mutation in UBA1 gene and is passed in a X-linked recessive manner by carrier mothers to affected sons. [1] [2] Affected babies have general muscle [en.wikipedia.org]

Babies typically have generalized muscle weakness, a weak cry and breathing distress. [mda.org]

Glycogen Storage Disease Type 13

[…] isoenzyme) gene: PKM2; AR tissues: Sk muscle, RBC Clinical Sx: muscle cramps and persistent generalized muscle weakness; myoglobinuria upon exertion but no hemolytic anemia [quizlet.com]

muscle weakness and fatigability. [web.expasy.org]

[…] beta enolase gene: ENO3; AR tissues: sk muscle glycogen levels: inc. amount Clinical Sx: Adult onset of exercise-induced myalgia, generalized muscle weakness and fatigability [quizlet.com]

Autosomal Recessive Centronuclear Myopathy

The X-linked neonatal form (XLCNM) is due to mutations in MTM1 and involves a severe and generalized muscle weakness at birth. [ncbi.nlm.nih.gov]

People with this condition may have droopy eyelids (ptosis) and weakness in the muscles that control eye movement (ophthalmoplegia). [acronymattic.com]

The majority of patients exhibit distal or proximal muscle weakness as a first symptom, presenting as general muscle weakness, eyelid drooping, extraocular muscle paralysis [spandidos-publications.com]

Mitochondrial Myopathy with Reversible Cytochrome C Oxidase Deficiency

muscle weakness in infancy that is associated with lactic acidosis. [journals.sagepub.com]

In addition to cardiomyopathy, our patient suffered from generalized muscle weakness and hypotonia. [docslide.net]

Such symptoms may include generalized muscle weakness as well as heart problems (cardiomyopathy) and kidney dysfunction. [rarediseases.org]

Transient Neonatal Myasthenia Gravis

The newborn presented with generalized muscle weakness, respiratory distress, weak sounding, anaemia, and poor sucking. Mechanical ventilation was necessary. [ncbi.nlm.nih.gov]

Known as transient neonatal myasthenia gravis, the condition may be characterized by generalized muscle weakness and low muscle tone (hypotonia); impaired sucking or swallowing [rarediseases.org]

In these infants general muscle weakness is noticeable together with deficient suck, lethargy, and breathing difficulty until the fourth day upon birth. [intechopen.com]

Adult Spinal Muscular Atrophy

Symptoms of this condition may include: General muscle weakness Trembling Twitching Minor difficulty breathing Because X-linked spinal muscular atrophy is carried on the X [cedars-sinai.edu]

They typically have generalized muscle weakness and may require braces, walkers, or a wheelchair for assistance. Life expectancy may extend to the 20s and 30s. [chw.org]

They typically have generalized muscle weakness and may require braces, walkers, or a wheelchair for assistance. Life-expectancy may extend to the 20s and 30s. [stanfordchildrens.org]

Ventricular Extrasystoles with Syncopal Episodes - Perodactyly - Robin Sequence

Syncope MedGen UID: 21443 •Concept ID: C0039070 • Sign or Symptom Syncope refers to a generalized weakness of muscles with loss of postural tone, inability to stand upright [ncbi.nlm.nih.gov]

Adult-Onset Nemaline Myopathy

It occurs in individuals between the ages of 20-50 who develop generalized muscle weakness that may progress rapidly. Muscle pain (myalgia) may also occur. [rarediseases.org]

Nemaline Myopathy Type 9

It occurs in individuals between the ages of 20-50 who develop generalized muscle weakness that may progress rapidly. Muscle pain (myalgia) may also occur. [rarediseases.org]

The common clinical manifestation of NM is its onset, characterized by hypotonia or general weakness predominantly affecting facial, axial and proximal limb muscles. [spandidos-publications.com]

weakness. [emedicine.medscape.com]

Muscular Dystrophy-Dystroglycanopathy Type A3

Clinical presentation includes variety of brain, eye and muscle abnormality like generalized hypotonia, muscle weakness, developmental delay with mental retardation and seizures [fortunejournals.com]

One should consider a diagnosis of CMD in any neonate or infant who presents with generalized weakness (usually proximal greater than distal, and weakness greater in arms [scielo.br]

CMD is a general term for muscular dystrophies that develop at, or within a few months after birth, with symptoms of muscle weakness and muscle hypotonia. [karger.com]

Early-Onset Myopathy with Fatal Cardiomyopathy

muscle weakness involving also the facial muscles, pseudohypertrophy of lower limb muscles, and joint contractures, associated with childhood onset of rapidly progressive [orpha.net]

Early-onset myopathy with fatal cardiomyopathy Disease definition A rare genetic neuromuscular disease characterized by neonatal or infancy onset of delayed motor development, generalized [orpha.net]

Autosomal Dominant Progressive External Ophthalmoplegia Type 2

[…] trié(s) par (Pertinence décroissant(e), Date de parution décroissant(e), Date de parution décroissant(e), Système de projection du document croissant(e)) | Mettre toutes les notices dans le panier | Faire une suggestion | Ajouter un critère de recherche Etendre la recherche sur niveau(x) vers le bas Article[…] [myobase.org]

Myoadenylate Deaminase Deficiency

Generalized muscle pair is often manifested. [accessanesthesiology.mhmedical.com]

The clinical manifestations include exercise-induced myopathy, post-exertional muscle weakness or cramping, prolonged fatigue after exertion, and limping infant caused by [accessanesthesiology.mhmedical.com]

At a glance It is an inherited or secondarily acquired disorder of muscle purine nucleotide metabolism. [accessanesthesiology.mhmedical.com]

Sengers Syndrome

The generalized muscle weakness can cause motor development to be delayed, despite normal intelligence.[2] Genetics[edit] A variety of specialists can make the diagnosis, [en.wikipedia.org]

A thickened heart muscle impairs its pumping ability (hypertrophic cardiomyopathy). [en.wikipedia.org]

UNC80 Deficiency

Muscle tone is generally weak (hypotonia), but affected individuals may have increased muscle tone (hypertonia) in the arms and legs. [medlineplus.gov]

Klippel-Feil Syndrome Type 4 with Nemaline Myopathy and Facial Dysmorphism

[…] hypotonia Microcephaly Scoliosis Micrognathia Motor delay Ptosis Abnormal facial shape Muscle weakness Myopathy And another 19 symptoms. [mendelian.co]

Features Top most frequent phenotypes and symptoms related to Klippel-feil Syndrome 4, Autosomal Recessive, With Nemaline Myopathy And Facial Dysmorphism; Kfs4 Short stature Generalized [mendelian.co]

Infantile-Onset Multisystem Autoimmune Disease Type 1

Dermatomyositis causes muscle weakness, plus a skin rash. [thermofisher.com]

weakness, usually in the muscles closest to the trunk of your body. [thermofisher.com]

General symptoms of myositis include fatigue after walking or standing, tripping or falling, and trouble swallowing or breathing.1,2 CTDs are a group of inflammatory, immune-mediated [thermofisher.com]

Autoimmune Disease of the Musculoskeletal System

Dermatomyositis causes muscle weakness, plus a skin rash. [thermofisher.com]

weakness, usually in the muscles closest to the trunk of your body. [thermofisher.com]

Secondary Myopathy

Clinical signs include generalized weakness, ventroflexion of the neck, abnormal gait, anorexia, and muscle pain. The neurologic examination is normal. [msdvetmanual.com]

It occurs in individuals between the ages of 20-50 who develop generalized muscle weakness that may progress rapidly. Muscle pain (myalgia) may also occur. [rarediseases.org]

[…] blocking agents Acute generalized weakness including respiratory muscles Serum CK can be normal or elevated NCS: low amplitude CMAPs with relatively normal SNAPs EMG: fibs [neurology.mhmedical.com]

Juvenile Myasthenia Gravis

/fever 4/5 (80) Proliferative GN 3/5 (60) Skin involvement 2/5 (40) Cytopenias 2/5 (40) Presenting features of the 5 patients attributable to JMG Generalized muscle weakness [academic.oup.com]

The patients present with a wide range of symptoms-from isolated intermittent ocular symptoms to general muscle weakness with or without respiratory insufficiency. [ncbi.nlm.nih.gov]

[…] proximal symmetrical muscle weakness. [lupinepublishers.com]