Generalized Muscle Weakness: Causes & Reasons

Possible Causes for Generalized Muscle Weakness

Other symptoms can include hypokalemia (low blood potassium level), headache and muscle weakness. [uwhealth.org]

[…] see Preferred Response PREFERRED RESPONSE 2 Sorry, this question is for PEAK Premium Subscribers only (M1.EC.42) A 47-year-old male presents with a primary complaint of generalized [medbullets.com]

Late-Onset Pompe Disease

In the infantile-onset form of the disease, symptoms present in the first month or year of life with hypotonia, macroglossia, generalized muscle weakness or delayed motor [ncbi.nlm.nih.gov]

muscle weakness, hypotonia, respiratory distress, and hypertrophic cardiomyopathy as main clinical features. [ncbi.nlm.nih.gov]

Classical infantile Pompe disease presents in the first few months of life with hypertrophic cardiomyopathy, generalized muscle weakness, and respiratory distress [5]. [ncbi.nlm.nih.gov]

Congenital Myopathy with Excess of Thin Filaments

muscle weakness. [malacards.org]

muscle weakness, waddling gait and facial paresis. [malacards.org]

[…] excitation-contraction coupling Congenital Myopathy Severity of presentation varies w/ age Generalized hypotonic w/ particular weakness in bulbar neck and respiratory muscles [quizlet.com]

Singleton Merten Syndrome

In 2 of the 4 patients, there was also generalized muscle weakness and atrophy beginning in the first or second year of life following a febrile illness. [findzebra.com]

Additional features included generalized muscle weakness and atrophy, and chronic psoriasiform skin eruptions. [orpha.net]

Generalized muscle weakness Muscle atrophy Treatment Treatment is typically directed toward the specific symptoms that are present in each individual. [wikidoc.org]

Multicore Myopathy with External Ophthalmoplegia

weakness ; Decreased fetal movement ; Difficulty running ; Exercise-induced myalgia ; External ophthalmoplegia ; Facial palsy ; Feeding difficulties in infancy ; Generalized [mousephenotype.org]

Learn more about how to achieve it with Mendelian Learn more Other signs and symptoms that you may find interesting Autoimmunity and Generalized muscle weakness, related diseases [mendelian.co]

Generalized muscle weakness 0003324 Hydrops fetalis 0001789 Muscular hypotonia Low or weak muscle tone 0001252 Neonatal hypotonia Low muscle tone, in neonatal onset 0001319 [rarediseases.info.nih.gov]

Distal Spinal Muscular Atrophy Type 4

Based on the pattern of weakness, we identified three groups: 13 patients with generalized weakness (group 1); eight patients with symmetrical, distal muscle weakness (group [academic.oup.com]

Presentation Spinal muscular atrophy (SMA) generally presents with muscle weakness and wasting. The limbs, respiratory and bulbar muscles and brainstem can be affected. [patient.info]

The clinical phenotype can include congenital hypotonia, generalized muscle weakness, delayed motor milestones, feeding difficulties, and facial muscle involvement. [mayomedicallaboratories.com]

Congenital Fiber-Type Disproportion Myopathy

Symptoms - Congenital fiber type disproportion Major symptoms may include loss of muscle tone (hypotonia) and generalized muscle weakness. [checkorphan.org]

[…] bulbar muscles ; Flexion contracture of finger ; Generalized muscle weakness ; High palate ; Hip contracture ; Hyperlordosis ; Intellectual disability ; Joint laxity ; Knee [beta.mousephenotype.org]

muscle weakness. [invitae.com]

Nemaline Myopathy

The severity and pattern of muscle weakness varies, but most affected individuals show mildly delayed motor development, hypotonia, generalized muscle weakness, and weakness [diseaseinfosearch.org]

In the patient with the severe infantile form, respiratory failure paralleled the generalized muscle weakness, whereas the 3 patients with the benign infantile form suddenly [ncbi.nlm.nih.gov]

Nemaline myopathy is a common form of congenital myopathy manifesting with nonprogressive generalized muscle weakness, hypotonia, and electron-dense protein inclusions in [ncbi.nlm.nih.gov]

X-linked Distal Spinal Muscular Atrophy Type 3

Symptoms of this condition may include: General muscle weakness Trembling Twitching Minor difficulty breathing Because X-linked spinal muscular atrophy is carried on the X [cedars-sinai.edu]

The disease is caused by a mutation in UBA1 gene and is passed in a X-linked recessive manner by carrier mothers to affected sons. [1] [2] Affected babies have general muscle [en.wikipedia.org]

Babies typically have generalized muscle weakness, a weak cry and breathing distress. [mda.org]

Rigid Spine Syndrome

Diseases related with Edema and Generalized muscle weakness In the following list you will find some of the most common rare diseases related to Edema and Generalized muscle [mendelian.co]

0001371 Generalized amyotrophy Diffuse skeletal muscle wasting Generalized muscle degeneration Muscle atrophy, generalized [ more ] 0003700 Generalized muscle weakness 0003324 [rarediseases.info.nih.gov]

Infants with RSMD generally display muscle weakness either at birth or within the first few months of life. [musculardystrophynews.com]

Myasthenia Gravis

Some patients develop generalized muscle weakness, which may become serious with respiratory muscle weakness. [orpha.net]

In the juvenile form, onset is before 18 years of age (juvenile myasthenia gravis; see this term) and patients also present with ocular and possibly generalized muscle weakness [orpha.net]

Patients have fluctuating weakness, worsening with repetitive activities, heat and stress while improving with rest and with involvement of skeletal muscle groups of ocular [orpha.net]

Glycogen Storage Disease Type 13

[…] isoenzyme) gene: PKM2; AR tissues: Sk muscle, RBC Clinical Sx: muscle cramps and persistent generalized muscle weakness; myoglobinuria upon exertion but no hemolytic anemia [quizlet.com]

muscle weakness and fatigability. [web.expasy.org]

[…] beta enolase gene: ENO3; AR tissues: sk muscle glycogen levels: inc. amount Clinical Sx: Adult onset of exercise-induced myalgia, generalized muscle weakness and fatigability [quizlet.com]

Miller-Fisher Syndrome

Additional symptoms include generalized muscle weakness and respiratory failure. [ninds.nih.gov]

It is characterized by abnormal muscle coordination, paralysis of the eye muscles, and absence of the tendon reflexes. [ninds.nih.gov]

Autosomal Recessive Centronuclear Myopathy

The X-linked neonatal form (XLCNM) is due to mutations in MTM1 and involves a severe and generalized muscle weakness at birth. [ncbi.nlm.nih.gov]

People with this condition may have droopy eyelids (ptosis) and weakness in the muscles that control eye movement (ophthalmoplegia). [acronymattic.com]

The majority of patients exhibit distal or proximal muscle weakness as a first symptom, presenting as general muscle weakness, eyelid drooping, extraocular muscle paralysis [spandidos-publications.com]

Mitochondrial Myopathy with Reversible Cytochrome C Oxidase Deficiency

muscle weakness in infancy that is associated with lactic acidosis. [journals.sagepub.com]

In addition to cardiomyopathy, our patient suffered from generalized muscle weakness and hypotonia. [docslide.net]

Clinically, patients had severe generalized muscle hypotonia and weakness from birth to 3 months of age. [pediatricneurologybriefs.com]

Adult Spinal Muscular Atrophy

Symptoms of this condition may include: General muscle weakness Trembling Twitching Minor difficulty breathing Because X-linked spinal muscular atrophy is carried on the X [cedars-sinai.edu]

They typically have generalized muscle weakness and may require braces, walkers, or a wheelchair for assistance. Life expectancy may extend to the 20s and 30s. [chw.org]

They typically have generalized muscle weakness and may require braces, walkers, or a wheelchair for assistance. Life-expectancy often extends into adulthood. [texaschildrens.org]

Transient Neonatal Myasthenia Gravis

The newborn presented with generalized muscle weakness, respiratory distress, weak sounding, anaemia, and poor sucking. Mechanical ventilation was necessary. [ncbi.nlm.nih.gov]

In these infants general muscle weakness is noticeable together with deficient suck, lethargy, and breathing difficulty until the fourth day upon birth. [intechopen.com]

Known as transient neonatal myasthenia gravis, the condition may be characterized by generalized muscle weakness and low muscle tone (hypotonia); impaired sucking or swallowing [rarediseases.org]

Secondary Myopathy

Clinical signs include generalized weakness, ventroflexion of the neck, abnormal gait, anorexia, and muscle pain. The neurologic examination is normal. [msdvetmanual.com]

It occurs in individuals between the ages of 20-50 who develop generalized muscle weakness that may progress rapidly. Muscle pain (myalgia) may also occur. [rarediseases.org]

Clinically, the patient generally experiences muscle weakness, pain, cramps, muscle tenderness, and spasms in various degrees. [emedicine.medscape.com]

Congenital Merosin-Positive Muscular Dystrophy

Infants with FCMD have generalized muscle weakness, diminished muscle tone (hypotonia), poor sucking ability, and a weak cry. [rarediseases.org]

From birth, he exhibited marked hypotonia with generalized muscle weakness. By 3 years of age, the patient was able to hold his head up but was unable to sit alone. [pediatricneurosciences.com]

Congenital Muscular Dystrophy Type 1A

From birth, he exhibited marked hypotonia with generalized muscle weakness. By 3 years of age, the patient was able to hold his head up but was unable to sit alone. [pediatricneurosciences.com]

Infants with FCMD have generalized muscle weakness, diminished muscle tone (hypotonia), poor sucking ability, and a weak cry. [rarediseases.org]

Physical examination showed generalized muscle weakness and contractures of elbows, wrists, knees, and ankles. However, we detected a new mutation in patient 1 and 2. [pediatricneurosciences.com]

Steroid Myopathy

Acute steroid myopathy physical findings are as follows: Generalized muscle weakness, not limited to a more proximal distribution, is noted. [emedicine.medscape.com]

She had been suffering, for about 3 years from progressive muscle weakness of the limbs, accompanied by general paresthesia, cramps of the calves and burning muscle pain both [ncbi.nlm.nih.gov]

Acute SM is the rapid onset of progressive generalized weakness as well as proximal and distal muscles weakness including respiratory muscle weakness occurring within a week [symptoma.com]

Myasthenic Crisis

In MG, patients have generalized muscle weakness due to the presence of acetylcholine receptor (AChR) autoantibodies which target the motor end plate through direct inhibition [symptoma.com]

Seventh and eighth decades in men  Patients complain of specific muscle weakness, not generalized fatigue 10. [slideshare.net]

However, generalized muscle weakness in MG patients can at times mask accessory muscle usage. [myasthenia.org]

Fingerprint Body Myopathy

Congenital birth Symptoms include general muscle weakness and possible joint deformities; disease progresses slowly; shortened life span. [myhealth.umassmemorial.org]

Within few years the disease progressed to generalized muscle weakness and atrophy, ptosis, ophthalmoplegia externa and areflexia. [scipers.com]

muscle atrophy, and muscle weakness affecting especially axial muscles and leading to spine rigidity, severe scoliosis, and respiratory insufficiency. [gopubmed.org]

Muscular Dystrophy-Dystroglycanopathy Type B6

Infants with FCMD have generalized muscle weakness, diminished muscle tone (hypotonia), poor sucking ability, and a weak cry. [rarediseases.org]

From birth, he exhibited marked hypotonia with generalized muscle weakness. By 3 years of age, the patient was able to hold his head up but was unable to sit alone. [pediatricneurosciences.com]

Abnormal facial characteristics, bifacial weakness, thin habitus with generalized muscle wasting were seen in all patients. [neurologyindia.com]

Myopathy

In conclusion, the MMT8 total score is a reliable assessment to consider general muscle weakness in people with myositis but not for single muscle groups. [ncbi.nlm.nih.gov]

Congenital myopathies can cause severe, general muscle weakness that complicates basic activities like swallowing and breathing. [mda.org]

muscle weakness Cerebral hypomyelination, less often cortical dysplasia Normal intelligence usually, some with MR (~6%) and seizures (~8%) Partial deficiency leads to milder [slideshare.net]

Acetazolamide-Responsive Myotonia

It is an autosomal dominant disorder manifested by episodic flaccid generalized muscle weakness associated with falls of serum potassium levels. [genome.ucsc.edu]

Two recent reports describe marked myotonia, generalized moderate weakness, and generalized muscle hypertrophy in homozygous individuals in kindreds with dominant chloride [clinicalgate.com]

Neonates present with feeding problems, choking, feeble cry, and facial, bulbar, and generalized skeletal muscle weakness. [blueprintgenetics.com]

Neuromuscular Junction Disorder

Congenital birth Symptoms include general muscle weakness and possible joint deformities; disease progresses slowly; shortened life span. [hopkinsmedicine.org]

The boy had a severe delay in psychomotor development, no verbal contact, generalized hypotonia, fatiguable muscle weakness, myopathic face with bilateral ptosis, hyperextensible [neurology.org]

KEY FEATURE • Ocular or generalized muscle weakness. [medtextfree.wordpress.com]

Nemaline Myopathy Type 5

weakness and foot drop Adult-Onset Nemaline Myopathy (exceptionally rare): variable onset and severity: apparent between 20-50 years of age; rapidly progressing generalized [patientworthy.com]

Most develop generalized muscle weakness between the ages of 20 and 50 without prior symptoms or family history, which may progress rapidly. [mgz-muenchen.de]

Common features include generalized muscle weakness with or without facial weakness and ophthalmoplegia (paralysis of the eye muscles). [encyclopedia.com]

Myotonia permanens

It is an autosomal dominant disorder manifested by episodic flaccid generalized muscle weakness associated with falls of serum potassium levels. [genome.ucsc.edu]

[…] hypotonia Muscle weakness Feeding difficulties Fever Fatigue Elevated serum creatine phosphokinase Myalgia Apnea Paralysis Cyanosis And another 9 symptoms. [mendelian.co]

Two recent reports describe marked myotonia, generalized moderate weakness, and generalized muscle hypertrophy in homozygous individuals in kindreds with dominant chloride [clinicalgate.com]

Early-Onset Myopathy with Fatal Cardiomyopathy

muscle weakness involving also the facial muscles, pseudohypertrophy of lower limb muscles, and joint contractures, associated with childhood onset of rapidly progressive [orpha.net]

Early-onset myopathy with fatal cardiomyopathy Disease definition A rare genetic neuromuscular disease characterized by neonatal or infancy onset of delayed motor development, generalized [orpha.net]