Generalized Muscle Weakness: Causes & Reasons

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Possible Causes for Generalized Muscle Weakness

Conn Syndrome

muscle weakness. [medbullets.com]

Other symptoms can include hypokalemia (low blood potassium level), headache and muscle weakness. [uwhealth.org]

[…] see Preferred Response PREFERRED RESPONSE 2 Sorry, this question is for PEAK Premium Subscribers only (M1.EC.42) A 47-year-old male presents with a primary complaint of generalized [medbullets.com]

Autosomal Dominant Progressive External Ophthalmoplegia Type 2

Rigid Spine Syndrome

Diseases related with Edema and Generalized muscle weakness In the following list you will find some of the most common rare diseases related to Edema and Generalized muscle [mendelian.co]

0001371 Generalized amyotrophy Diffuse skeletal muscle wasting Generalized muscle degeneration Muscle atrophy, generalized [ more ] 0003700 Generalized muscle weakness 0003324 [rarediseases.info.nih.gov]

This form of the condition also causes general muscle weakness and feeding difficulties that appear in the first year of life. [ghr.nlm.nih.gov]

Congenital Myopathy with Excess of Thin Filaments

muscle weakness. [malacards.org]

muscle weakness, waddling gait and facial paresis. [malacards.org]

[…] excitation-contraction coupling Congenital Myopathy Severity of presentation varies w/ age Generalized hypotonic w/ particular weakness in bulbar neck and respiratory muscles [quizlet.com]

Singleton Merten Syndrome

Additional features included generalized muscle weakness and atrophy, and chronic psoriasiform skin eruptions. [orpha.net]

Other physical findings may include generalized muscle weakness; progressive muscle atrophy ; growth delay; delays in motor development; skin conditions; and/or malformation [globalgenes.org]

Multicore Myopathy with External Ophthalmoplegia

weakness ; Decreased fetal movement ; Difficulty running ; Exercise-induced myalgia ; External ophthalmoplegia ; Facial palsy ; Feeding difficulties in infancy ; Generalized [mousephenotype.org]

Learn more about how to achieve it with Mendelian Learn more Other signs and symptoms that you may find interesting Autoimmunity and Generalized muscle weakness, related diseases [mendelian.co]

Generalized muscle weakness 0003324 Hydrops fetalis 0001789 Muscular hypotonia Low or weak muscle tone 0001252 Neonatal hypotonia Low muscle tone, in neonatal onset 0001319 [rarediseases.info.nih.gov]

Nemaline Myopathy

In the patient with the severe infantile form, respiratory failure paralleled the generalized muscle weakness, whereas the 3 patients with the benign infantile form suddenly [ncbi.nlm.nih.gov]

Nemaline myopathy is a common form of congenital myopathy manifesting with nonprogressive generalized muscle weakness, hypotonia, and electron-dense protein inclusions in [ncbi.nlm.nih.gov]

There was a general muscle weakness and lack of muscle strength that was more obvious in the proximal muscles. One could walk independently and one with minimal support. [ncbi.nlm.nih.gov]

Distal Spinal Muscular Atrophy Type 4

Based on the pattern of weakness, we identified three groups: 13 patients with generalized weakness (group 1); eight patients with symmetrical, distal muscle weakness (group [academic.oup.com]

The clinical phenotype can include congenital hypotonia, generalized muscle weakness, delayed motor milestones, feeding difficulties, and facial muscle involvement. [mayomedicallaboratories.com]

DSMA4 is characterized by childhood onset, generalized muscle weakness and atrophy with denervation and normal sensation. Bulbar symptoms and pyramidal signs are absent. [uniprot.org]

Congenital Fiber-Type Disproportion Myopathy

[…] bulbar muscles ; Flexion contracture of finger ; Generalized muscle weakness ; High palate ; Hip contracture ; Hyperlordosis ; Intellectual disability ; Joint laxity ; Knee [beta.mousephenotype.org]

muscle weakness. [invitae.com]

Symptoms - Congenital fiber type disproportion Major symptoms may include loss of muscle tone (hypotonia) and generalized muscle weakness. [checkorphan.org]

Miller-Fisher Syndrome

Additional symptoms include generalized muscle weakness and respiratory failure. [ninds.nih.gov]

It is characterized by abnormal muscle coordination, paralysis of the eye muscles, and absence of the tendon reflexes. [ninds.nih.gov]

Glycogen Storage Disease Type 13

[…] isoenzyme) gene: PKM2; AR tissues: Sk muscle, RBC Clinical Sx: muscle cramps and persistent generalized muscle weakness; myoglobinuria upon exertion but no hemolytic anemia [quizlet.com]

muscle weakness and fatigability. [web.expasy.org]

[…] beta enolase gene: ENO3; AR tissues: sk muscle glycogen levels: inc. amount Clinical Sx: Adult onset of exercise-induced myalgia, generalized muscle weakness and fatigability [quizlet.com]

Myasthenia Gravis

Some patients develop generalized muscle weakness, which may become serious with respiratory muscle weakness. [orpha.net]

In the juvenile form, onset is before 18 years of age (juvenile myasthenia gravis; see this term) and patients also present with ocular and possibly generalized muscle weakness [orpha.net]

Patients have fluctuating weakness, worsening with repetitive activities, heat and stress while improving with rest and with involvement of skeletal muscle groups of ocular [orpha.net]

Autosomal Recessive Centronuclear Myopathy

The X-linked neonatal form (XLCNM) is due to mutations in MTM1 and involves a severe and generalized muscle weakness at birth. [ncbi.nlm.nih.gov]

People with this condition may have droopy eyelids (ptosis) and weakness in the muscles that control eye movement (ophthalmoplegia). [acronymattic.com]

The majority of patients exhibit distal or proximal muscle weakness as a first symptom, presenting as general muscle weakness, eyelid drooping, extraocular muscle paralysis [spandidos-publications.com]

X-linked Distal Spinal Muscular Atrophy Type 3

Symptoms of this condition may include: General muscle weakness Trembling Twitching Minor difficulty breathing Because X-linked spinal muscular atrophy is carried on the X [cedars-sinai.edu]

The disease is caused by a mutation in UBA1 gene and is passed in a X-linked recessive manner by carrier mothers to affected sons. [1] [2] Affected babies have general muscle [en.wikipedia.org]

Babies typically have generalized muscle weakness, a weak cry and breathing distress. [mda.org]

Mitochondrial Myopathy with Reversible Cytochrome C Oxidase Deficiency

muscle weakness in infancy that is associated with lactic acidosis. [journals.sagepub.com]

In addition to cardiomyopathy, our patient suffered from generalized muscle weakness and hypotonia. [docslide.net]

Such symptoms may include generalized muscle weakness as well as heart problems (cardiomyopathy) and kidney dysfunction. [rarediseases.org]

Adult Spinal Muscular Atrophy

Symptoms of this condition may include: General muscle weakness Trembling Twitching Minor difficulty breathing Because X-linked spinal muscular atrophy is carried on the X [cedars-sinai.edu]

They typically have generalized muscle weakness and may require braces, walkers, or a wheelchair for assistance. Life expectancy may extend to the 20s and 30s. [chw.org]

They typically have generalized muscle weakness and may require braces, walkers, or a wheelchair for assistance. Life-expectancy may extend to the 20s and 30s. [stanfordchildrens.org]

Congenital Muscular Dystrophy Type 1A

From birth, he exhibited marked hypotonia with generalized muscle weakness. By 3 years of age, the patient was able to hold his head up but was unable to sit alone. [pediatricneurosciences.com]

Infants with FCMD have generalized muscle weakness, diminished muscle tone (hypotonia), poor sucking ability, and a weak cry. [rarediseases.org]

Physical examination showed generalized muscle weakness and contractures of elbows, wrists, knees, and ankles. However, we detected a new mutation in patient 1 and 2. [pediatricneurosciences.com]

Congenital Merosin-Positive Muscular Dystrophy

Infants with FCMD have generalized muscle weakness, diminished muscle tone (hypotonia), poor sucking ability, and a weak cry. [rarediseases.org]

From birth, he exhibited marked hypotonia with generalized muscle weakness. By 3 years of age, the patient was able to hold his head up but was unable to sit alone. [pediatricneurosciences.com]

Fingerprint Body Myopathy

Congenital birth Symptoms include general muscle weakness and possible joint deformities; disease progresses slowly; shortened life span. [myhealth.umassmemorial.org]

Within few years the disease progressed to generalized muscle weakness and atrophy, ptosis, ophthalmoplegia externa and areflexia. [scipers.com]

muscle atrophy, and muscle weakness affecting especially axial muscles and leading to spine rigidity, severe scoliosis, and respiratory insufficiency. [gopubmed.org]

Transient Neonatal Myasthenia Gravis

The newborn presented with generalized muscle weakness, respiratory distress, weak sounding, anaemia, and poor sucking. Mechanical ventilation was necessary. [ncbi.nlm.nih.gov]

In these infants general muscle weakness is noticeable together with deficient suck, lethargy, and breathing difficulty until the fourth day upon birth. [intechopen.com]

Known as transient neonatal myasthenia gravis, the condition may be characterized by generalized muscle weakness and low muscle tone (hypotonia); impaired sucking or swallowing [rarediseases.org]

Myopathy

In conclusion, the MMT8 total score is a reliable assessment to consider general muscle weakness in people with myositis but not for single muscle groups. [ncbi.nlm.nih.gov]

Congenital myopathies can cause severe, general muscle weakness that complicates basic activities like swallowing and breathing. [mda.org]

muscle weakness Cerebral hypomyelination, less often cortical dysplasia Normal intelligence usually, some with MR (~6%) and seizures (~8%) Partial deficiency leads to milder [slideshare.net]

Nemaline Myopathy Type 5

weakness and foot drop Adult-Onset Nemaline Myopathy (exceptionally rare): variable onset and severity: apparent between 20-50 years of age; rapidly progressing generalized [patientworthy.com]

Most develop generalized muscle weakness between the ages of 20 and 50 without prior symptoms or family history, which may progress rapidly. [mgz-muenchen.de]

It occurs in individuals between the ages of 20-50 who develop generalized muscle weakness that may progress rapidly. Muscle pain (myalgia) may also occur. [rarediseases.org]

Secondary Myopathy

It occurs in individuals between the ages of 20-50 who develop generalized muscle weakness that may progress rapidly. Muscle pain (myalgia) may also occur. [rarediseases.org]

Clinical signs include generalized weakness, ventroflexion of the neck, abnormal gait, anorexia, and muscle pain. The neurologic examination is normal. [msdvetmanual.com]

[…] blocking agents Acute generalized weakness including respiratory muscles Serum CK can be normal or elevated NCS: low amplitude CMAPs with relatively normal SNAPs EMG: fibs [neurology.mhmedical.com]

Myasthenic Crisis

In MG, patients have generalized muscle weakness due to the presence of acetylcholine receptor (AChR) autoantibodies which target the motor end plate through direct inhibition [symptoma.com]

However, generalized muscle weakness in MG patients can at times mask accessory muscle usage. [myasthenia.org]

Seventh and eighth decades in men  Patients complain of specific muscle weakness, not generalized fatigue 10. [slideshare.net]

Muscular Dystrophy-Dystroglycanopathy Type B6

Infants with FCMD have generalized muscle weakness, diminished muscle tone (hypotonia), poor sucking ability, and a weak cry. [rarediseases.org]

From birth, he exhibited marked hypotonia with generalized muscle weakness. By 3 years of age, the patient was able to hold his head up but was unable to sit alone. [pediatricneurosciences.com]

Abnormal facial characteristics, bifacial weakness, thin habitus with generalized muscle wasting were seen in all patients. [neurologyindia.com]

Antenatal-Onset Multicore Myopathy with Arthrogryposis

Generalized muscle weakness that can help you solving undiagnosed cases. [mendelian.co]

Three other subgroups include a moderate form characterized by generalized muscle weakness which predominantly affects the pelvic girdle and hands with amyotrophy and hyperlaxity [fitness-vip.com]

Physical examination showed myopathic facies with extraocular weakness and generalized muscle wasting and weakness. [bio2rdf.org]

Infantile-Onset Multisystem Autoimmune Disease Type 1

Dermatomyositis causes muscle weakness, plus a skin rash. [thermofisher.com]

weakness, usually in the muscles closest to the trunk of your body. [thermofisher.com]

General symptoms of myositis include fatigue after walking or standing, tripping or falling, and trouble swallowing or breathing.1,2 CTDs are a group of inflammatory, immune-mediated [thermofisher.com]

Familial Primary Hypomagnesemia with Normocalciuria and Normocalcemia

muscle weakness 59 32 frequent (33%) Frequent (79-30%) HP:0003324 10 hyperactive deep tendon reflexes 59 32 frequent (33%) Frequent (79-30%) HP:0006801 11 moderate global [malacards.org]

muscle weakness 0003324 Hypocalciuria Low urine calcium levels 0003127 Hypokalemia Low blood potassium levels 0002900 Hypomagnesemia Low blood magnesium levels 0002917 Renal [rarediseases.info.nih.gov]

Other manifestations include the following: Convulsions Apathy Muscle cramps Hyperreflexia Acute organic brain syndromes Depression Generalized weakness Anorexia Vomiting [emedicine.medscape.com]

Juvenile Myasthenia Gravis

/fever 4/5 (80) Proliferative GN 3/5 (60) Skin involvement 2/5 (40) Cytopenias 2/5 (40) Presenting features of the 5 patients attributable to JMG Generalized muscle weakness [academic.oup.com]

The patients present with a wide range of symptoms-from isolated intermittent ocular symptoms to general muscle weakness with or without respiratory insufficiency. [ncbi.nlm.nih.gov]

[…] proximal symmetrical muscle weakness. [lupinepublishers.com]

Odontomatosis - Aortae Esophagus Stenosis Syndrome

Skeletal muscle atrophy Infantile onset Gait disturbance Tremor Cerebellar atrophy Generalized muscle weakness Limb muscle weakness Paralysis Abnormal cerebellum morphology [mendelian.co]

[…] cramps Intellectual disability Seizures Global developmental delay Generalized hypotonia Pica Ataxia Muscle weakness Spasticity Peripheral neuropathy Dysarthria Optic atrophy [mendelian.co]

[…] horn cell morphology Therapeutic abortion Internuclear ophthalmoplegia GM2-ganglioside accumulation Zebra bodies Autosomal dominant inheritance Neoplasm Memory impairment Muscle [mendelian.co]