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329 Possible Causes for Generalized Neonatal Hypotonia

  • Haddad Syndrome

    Results Upon the admission, the neonate patient presented with generalized muscular hypotonia and dysmorphic facial features, including downward-slanting palpebral fissures[omicsonline.org]

  • Lethal Infantile Mitochondrial Myopathy

    neonatal hypotonia 60 33 occasional (7.5%) Occasional (29-5%) HP:0008935 11 fatal liver failure in infancy 60 33 occasional (7.5%) Occasional (29-5%) HP:0006583 12 myopathy[malacards.org] 7.5%) Occasional (29-5%) HP:0002643 8 areflexia 60 33 occasional (7.5%) Occasional (29-5%) HP:0001284 9 lethargy 60 33 occasional (7.5%) Occasional (29-5%) HP:0001254 10 generalized[malacards.org]

  • Generalized Clonic or Tonic-Clonic Seizures

    ; pseudoadrenoleukodystrophy Related symptoms: Autosomal recessive inheritance Seizures Global developmental delay Generalized hypotonia Pica SOURCES: UMLS DOID SCTID MESH[mendelian.co] PEROXISOMAL ACYL-CoA OXIDASE DEFICIENCY Is also known as straight-chain acyl-coa oxidase deficiency, pseudoneonatal adrenoleukodystrophy;pseudo-nald; pseudo-neonatal adrenoleukodystrophy[mendelian.co]

  • Autism

    ., Van Kuilenburg AB, Janssens PM A neonate with recurrent vomiting and generalized hypotonia diagnosed with a deficiency of dihydropyrimidine dehydrogenase.[doi.org]

  • Neonatal Jaundice

    Physical Findings in Neonatal Jaundice Findings Timing of Jaundice Cause General examination Fever, tachycardia, respiratory distress First 24 h Accumulates 5 mg/dL/day ([merckmanuals.com] 86 mcmol/L/day) Pneumonia , TORCH infection, sepsis Lethargy, hypotonia May appear in the first 24–48 h Can be prolonged ( 2 wk) Hypothyroidism , metabolic disorder Macrosomia[merckmanuals.com] 86 mcmol/L/day) Pneumonia, TORCH infection, sepsis Lethargy, hypotonia May appear in the first 24–48 h Can be prolonged ( 2 wk) Hypothyroidism, metabolic disorder Macrosomia[merckmanuals.com]

  • Physiological Neonatal Jaundice

    Physical Findings in Neonatal Jaundice Findings Timing of Jaundice Cause General examination Fever, tachycardia, respiratory distress First 24 h Accumulates 5 mg/dL/day ([msdmanuals.com] 86 mcmol/L/day) Pneumonia, TORCH infection, sepsis Lethargy, hypotonia May appear in the first 24–48 h Can be prolonged ( 2 wk) Hypothyroidism, metabolic disorder Macrosomia[msdmanuals.com]

  • Early Infantile Epileptic Encephalopathy Type 2

    Our patient presented with neonatal hypotonia and feeding difficulties, then developed pharmacoresistant epileptic encephalopathy, characterized by multiple seizure types[ncbi.nlm.nih.gov] Neonates have poor suckling reflexes, hypotonia and manifest with generalized and symmetrical tonic spasms that can appear in clusters or singly and can last for up to 10[orpha.net] Electroencephalography demonstrated ictal generalized and interictal multifocal epileptiform abnormalities.[ncbi.nlm.nih.gov]

  • Arthrogryposis due to Muscular Dystrophy

    More about... 144 Myotubular Myopathy Neonates with myotubular myopathy present with facial weakness, ptosis, ophthalmoplegia, generalized weakness and hypotonia, and, at[pediatricneuro.com] Clinical findings are hypotonia, congenital hip dislocation, torticollis, contractures, arthrogryposis, distal laxity in the neonatal period, and generalized, slowly progressive[medlink.com] General features of all nemaline myopathies include minimally progressive or nonprogressive proximal limb, bulbar, and facial weakness starting in the neonatal or childhood[emedicine.medscape.com]

  • Arthrogryposis-Renal Dysfunction-Cholestasis Syndrome

    The neonate was admitted right after the birth with generalized hypotonia, poor feeding, and tachypnea.[ams.ac.ir] There was generalized hypotonia, hepatomegaly, and multiple contractures including talipes calcaneovalgus, dislocated hips, and radial deviation of the wrist (Figures 1 and[ams.ac.ir] The family had several consanguineous marriages and two cousins had died in the neonatal period of an unknown etiology.[ams.ac.ir]

  • Transient Familial Neonatal Hyperbilirubinemia

    Physical Findings in Neonatal Jaundice Findings Timing of Jaundice Cause General examination Fever, tachycardia, respiratory distress First 24 h Accumulates 5 mg/dL/day ([merckmanuals.com] 86 mcmol/L/day) Pneumonia, TORCH infection, sepsis Lethargy, hypotonia May appear in the first 24–48 h Can be prolonged ( 2 wk) Hypothyroidism, metabolic disorder Macrosomia[merckmanuals.com]

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