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16 Possible Causes for Generalized Polyspikes, Variable Psychomotor Retardation

  • West Syndrome

    […] clinical manifestations such as hypotonia, psychomotor retardation, and feeding difficulties.[ncbi.nlm.nih.gov] The generalized tonic seizures began with bi-frontal polyspikes on EEG. Our diagnosis was lissencephaly presenting with West syndrome and generalized tonic seizures.[ncbi.nlm.nih.gov] Leigh syndrome (LS) (sub-acute necrotizing encephalomyelopathy) is characterized by symmetric brain lesions occurring mainly in the basal ganglia and associated with variable[ncbi.nlm.nih.gov]

  • Myoclonic-Astatic Epilepsy

    retardation mainly affecting speech.[ipfs.io] Analysis of the ictal EEGs showed that all attacks corresponded to the generalized spike or polyspikes-and-wave complexes.[ncbi.nlm.nih.gov] […] spikes or polyspike-wave discharges at 2-3 Hz with an absence of focal spikes; Exclusion of other syndromes, specifically, cryptogenic Lennox-Gastaut syndrome, benign or[symptoma.com]

  • Early Infantile Epileptic Encephalopathy Type 2

    […] degree of psychomotor delay and cognitive impairment, ranging from mild to severe mental retardation [23].[journals.plos.org] […] slowing MRI-normal C-VI-7 16 yrs 9 mths 10 yrs GTCS, abs, MJ, FS 9 mths Mild – 6 yrs: generalized slowing 15 yrs: generalized polyspike wave MRI-normal C-VI-8 12 yrs 6 mths[dx.doi.org] […] members of the same family: onset of seizures is between 6 and 36 months, the patients present with a combination of febrile and afebrile seizures of various types and a variable[journals.plos.org]

  • Coffin-Lowry Syndrome

    Based on the clinical association of growth and psychomotor retardation with hypotonia, progressive skeletal deformations, characteristic facial dysmorphism, and large soft[accessanesthesiology.mhmedical.com] Our patient presented with recurrent unprovoked NCSE with an EEG showing a peculiar generalized pattern (long runs of polyspikes), typically seen in symptomatic generalized[karger.com] It characterized by moderate to severe psychomotor and growth retardation, characteristic facial features, skeletal deformities and tapering fingers in males.[alliedacademies.org]

  • Lethal Infantile Mitochondrial Myopathy

    Encephalomyopathic MDS Encephalomyopathic MDS embraces phenotypes characterized by infantile onset of hypotonia with severe psychomotor retardation, high blood lactate levels[ijponline.biomedcentral.com] […] an encephalopathy. • The finding of polyspike and wave discharges may be seen in patients with MELAS and MERRF. • Some patients may have evidence of myopathy on EMG. • On[slideshare.net] , progressive hyperkinetic-dystonic disorder, external ophthalmoplegia, deafness, generalized seizures and variable renal tubular dysfunction.[ijponline.biomedcentral.com]

  • Mitochondrial Neurogastrointestinal Encephalomyopathy

    Encephalomyopathic MDS Encephalomyopathic MDS embraces phenotypes characterized by infantile onset of hypotonia with severe psychomotor retardation, high blood lactate levels[ijponline.biomedcentral.com] […] an encephalopathy. • The finding of polyspike and wave discharges may be seen in patients with MELAS and MERRF. • Some patients may have evidence of myopathy on EMG. • On[slideshare.net] , progressive hyperkinetic-dystonic disorder, external ophthalmoplegia, deafness, generalized seizures and variable renal tubular dysfunction.[ijponline.biomedcentral.com]

  • Pachygyria-Mental Retardation-Seizures

    In conclusion, in patients with mental retardation, mild motor deficit and epilepsy characterized by tonic or atonic generalized seizures, interictal EEG with diffuse polyspike-wave[pubmed.cn] A classic type lissencephaly associated with psychomotor retardation and seizures.[nectarmutation.org] […] disability of variable severity.[mendelian.co]

  • Progressive Epilepsy-Intellectual Disability Syndrome, Type Finnish

    […] tonic–clonic seizures; (3) mild neurologic signs in motor function or coordination; (4) photosensitivity, with generalized spike-and-wave and polyspike-and-wave paroxysms[thieme-connect.com] […] and ranging from seizures and moderate psychomotor retardation to mild autistic features with speech and language delay Treatment: Supportive care Congenital disorders of[merckmanuals.com] […] and more frequent, consisting of polyspikes and slow waves REM sleep – Decreased spike waves Ictal EEG may demonstrate the following characteristics: Tonic seizure – Diffuse[emedicine.medscape.com]

  • Early Infantile Epileptic Encephalopathy Type 28

    […] spikes and polyspikes.[thieme-connect.com] SCAR12 is additionally characterized by onset of generalized seizures in infancy, and delayed psychomotor development with mental retardation.[selfdecode.com] Developmental delay 37 (100.0) Tone abnormalities 18 (48.6) Microcephaly 10 (27.0) Hemiplegia 2 (5.4) Visual defects 4 (10.8) Hearing deficit 1 (2.7) Neuroimaging Normal 9 (24.3) Generalized[indianpediatrics.net]

  • Early Infantile Epileptic Encephalopathy with Suppression-Burst

    The majority of affected patients had mild to severe psychomotor retardation. Hypotonia, hypertonia and dystonia were common as well [ 9 ].[bmcmedgenet.biomedcentral.com] However, it may show polyspike activity or generalized spike wave pattern later on.[neurologyindia.com] The seizure semiology was variable, including focal seizures, clonic seizures, tonic-clonic seizures, epileptic spasms, myoclonic and absence seizures, etc. [ 9, 12 ].[bmcmedgenet.biomedcentral.com]

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