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33 Possible Causes for Generalized Spike-and-Slow-Waves, Global Hypotonia

  • West Syndrome

    Interictal EEG displays diffuse and asynchronous high voltage spikes and slow waves suggesting the hypsarrhythmic pattern. B.[bmcneurol.biomedcentral.com] A 5 year-old boy exhibited global hypotonia with generalized muscle weakness from birth.[ncbi.nlm.nih.gov] His MRI also picked up that his brain wasn't quite fully formed at the front and sides and this had resulted in him having global developmental delay and hypotonia (floppy[netmums.com]

  • Generalized Clonic or Tonic-Clonic Seizures

    , poly spike discharges." [2] The clonic phase EEG will show "high amplitude activity that is typically interrrupted by slow waves to create a spike-and-slow-wave pattern.[en.wikipedia.org] […] developmental delay Generalized hypotonia SOURCES: ORPHANET OMIM ICD10 NCIT MONDO More info about NIEMANN-PICK DISEASE, TYPE C1; NPC1 Top 5 symptoms//phenotypes associated[mendelian.co] According to "Harrisons Manual of Medicine," the EEG during the tonic phase will show a "progressive increase in low-voltage fast wave activity, followed by generalized high-amplitude[en.wikipedia.org]

  • Encephalopathy

    We describe a multiplex consanguineous family in which four affected members presented with severe neonatal hypotonia, profound global developmental delay, progressive microcephaly[ncbi.nlm.nih.gov] Global developmental delay can be evident by this age or the patients may present with encephalopathy or hypotonia. 2 , 7 , 8 Classification by age of onset into an early[pediatrics.aappublications.org]

  • Neonatal Seizures

    At that time, neurological examination showed severe global hypotonia with consequent developmental delay; however no focal deficits were detected.[scielo.br]

  • Panayiotopoulos Syndrome

    An outpatient EEG 6 months later showed abundant multifocal, predominantly posterior, as well as irregular generalized spike-and-slow-wave discharges on normal background[ncbi.nlm.nih.gov] […] developmental delay, hypotonia, progressive microcephaly EEG findings: Burst-suppression pattern Myoclonic jerks do not correlate with EEG changes Management considerations[emilytam.com] EEG showed right occipital high-amplitude sharp and slow-wave complexes followed by brief generalized discharges of slow waves.[ncbi.nlm.nih.gov]

  • Familial Infantile Myoclonic Epilepsy

    Ictal EEG Generalized polyspike or spike and slow-wave discharges.[epilepsy.com] […] developmental delay, hypotonia, progressive microcephaly EEG findings: Burst-suppression pattern Myoclonic jerks do not correlate with EEG changes Management considerations[emilytam.com] EEG studies show diffuse background slowing with slow generalized spike wave activity. All affected boys had moderate to profound intellectual disability.[neurology.org]

  • Benign Familial Infantile Epilepsy

    […] background Irregular generalized spike or polyspike and slow wave complexes Photosensitive, decreased during sleep Prognosis: Slow progression, may live to 60s Lafora Disease[emilytam.com] The abnormal EEG findings that are most likely to correlate with clinical seizures include spikes or sharp waves, with or without concomitant slow waves, that are generalized[aafp.org] […] developmental delay, hypotonia, progressive microcephaly EEG findings: Burst-suppression pattern Myoclonic jerks do not correlate with EEG changes Management considerations[emilytam.com]

  • Autistic Disorder

    Scalp video-EEG recordings revealed an epileptic encephalopathy with generalized slow spike-and-wave complexes alternating with electrodecremental periods, which generally[ncbi.nlm.nih.gov] […] and/or global developmental delay (GDD) and may develop seizures later.[web.archive.org] Both nonspecific changes, such as slowing or asymmetry, and epileptiform discharges, consisting of spikes or sharp wave discharges, sharp slow waves, generalized spike-wave[doi.org]

  • Early Infantile Epileptic Encephalopathy 13

    EEG at that time showed generalized high amplitude multi-spike and slow waves.[bmcmedgenet.biomedcentral.com] All reported individuals with this condition, including the present case manifest global developmental delay, seizures, progressive postnatal microcephaly, hypotonia, thin[readbyqxmd.com] , 6 m 3.5 m Focal seizure, secondary generalized seizure, status epilepticus Can’t control head at 1-year-old Severe ID Diffuse slow waves in the background, spike at right[bmcmedgenet.biomedcentral.com]

  • Ohtahara Syndrome

    ) discharges or generalized spike wave and polyspike wave activity.[dx.doi.org] Results: In all 6 patients, global developmental delay and hypotonia were present from infancy, with onset of chorea around age 3-4 years.[mdsabstracts.org] Results All patients had global delay, central hypotonia and MD noted in early life (see online supplementary table 1, patient synopsis, SI).[jnnp.bmj.com]

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