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11 Possible Causes for Generalized Spike-and-Slow-Waves, Mild Cerebellar Hypoplasia, Paroxysmal Activity - Spikes

  • Benign Adult Familial Myoclonic Epilepsy

    , high-amplitude spike and slow-wave complexes 3.5 Hz, typically 4 s duration.  Absence seizures in JAE are more sporadic.  EEG is slightly faster with generalized spike[slideshare.net] This was referred to as posterior paroxysmal activity by Holmes et al.[euroformhealthcare.biz] hypoplasia-hydranencephaly syndrome Multiple acyl-CoA dehydrogenase deficiency Multiple acyl-CoA dehydrogenase deficiency, mild type Multiple acyl-CoA dehydrogenase deficiency[orpha.net]

  • West Syndrome

    Lennox-Gastaut Syndrome: LGS is characterized by multiple types of seizures and an abnormal EEG with generalized slow spikewave discharges.[cdkl5.com] Magnetic resonance imaging of the brain revealed mild cerebral and cerebellar atrophy, high-signal-intensity areas in the white matter, and hypoplasia of the corpus callosum[ncbi.nlm.nih.gov] Interictal EEG displays diffuse and asynchronous high voltage spikes and slow waves suggesting the hypsarrhythmic pattern. B.[bmcneurol.biomedcentral.com]

  • Unverricht-Lundborg Syndrome

    Slow ( 2.5 Hz) electroencephalographic spike and wave discharges in atypical absence epilepsy (ie, Lennox-Gastaut syndrome). Spike, generalized.[emedicine.medscape.com] […] myoclonic jerks AND/OR generalized tonic-clonic seizures Photosensitive, generalized spike-and-wave and polyspike-and-wave paroxysms on EEG EEG is always abnormal, even before[ncbi.nlm.nih.gov] hypoplasia-hydranencephaly syndrome Multiple acyl-CoA dehydrogenase deficiency Multiple acyl-CoA dehydrogenase deficiency, mild type Multiple acyl-CoA dehydrogenase deficiency[orpha.net]

  • Neuronal Ceroid Lipofuscinosis

    EEG revealed frequent generalized spikes, polyspikes, and waves, prominent on awakening and during photic stimulation without significant change throughout the clinical course[ncbi.nlm.nih.gov] In later recordings, background activity became slower, and paroxysmal activity tended to increase with age.[dovepress.com] cerebellar ataxia and white matter edema Leukonychia totalis Leukotriene C4 synthase deficiency Levine-Critchley syndrome Levy-Hollister syndrome Lewandowsky-Lutz syndrome[csbg.cnb.csic.es]

  • Angelman Syndrome

    EEG demonstrates high-amplitude 2-3Hz delta activity with spike and slow-wave discharges and sleep-activated generalized epileptiform discharges.[ncbi.nlm.nih.gov] The third pattern, 3–6 Hz activity punctuated by spikes and sharp waves in occipital leads, is associated with eye closure (C).[medicalmarijuana.com] Cerebellar hypoplasia Seizures Pathophysiology [ edit ] Adenylosuccinate lyase deficiency is responsible for a range of symptoms that involve psychomotor retardation, often[en.wikipedia.org]

  • Infantile-Onset Autosomal Recessive Nonprogressive Cerebellar Ataxia

    slow spike-and-wave discharges Affected LGS patients have different degrees of developmental delay and they often develop autism and intellectual disability 43 Patients react[centogene.com] […] ataxia and mental retardation known as the disequilibrium syndrome. 36, 45 Imaging shows significant cerebellar hypoplasia and mild cerebral cortex thickening and gyral simplification[ajnr.org] […] of cerebellum and corpus callosum [ 63 , 64 ] AOA3 (1 family) PIK3R5 615217 Oculomotor apraxia, sensorimotor involvement, teenage onset, cerebellar atrophy [ 65 ] SCAR13[cerebellumandataxias.biomedcentral.com]

  • Partington Syndrome

    slow spike-and-wave discharges Affected LGS patients have different degrees of developmental delay and they often develop autism and intellectual disability 43 Patients react[centogene.com] A non conservative missense mutation near the C-terminal aristaless domain caused unusually severe XLAG with microcephaly and mild cerebellar hypoplasia.[neuroscienceandgenetics.it] Interestingly, a non-conservative missense mutation near the C-terminal aristaless domain (p.A521T) causes unusually severe XLAG with microcephaly and mild cerebellar hypoplasia[epilepsygenetics.net]

  • Pachygyria-Mental Retardation-Seizures

    […] hemispheres being pronounced at the posterior region, generalized spike-slow-waves, and synchronized spike and sharp wave discharges at the posterior of the right hemisphere[dusunenadamdergisi.org] Interictal electroencephalography (EEG) showed occipital spikes and diffuse polyspike-wave paroxysms predominantly in the posterior region.[pubmed.cn] Autosomal recessive LIS with cerebellar hypoplasia consists of mild frontal predominant LIS, plus severe hippocampal and cerebellar hypoplasia and dysplasia.[karger.com]

  • Bilateral Temporo-Occipital Polymicrogyria

    Few reports described ictal EEGs: during the seizure the EEG often shows a runs of high voltage slow waves and generalized spike and wave discharges [ 2 – 4, 8 ].[ijponline.biomedcentral.com] Autosomal recessive LIS with cerebellar hypoplasia consists of mild frontal predominant LIS, plus severe hippocampal and cerebellar hypoplasia and dysplasia.[karger.com] cerebellar ver-mis hypoplasia in some patients.[documents.tips]

  • Progressive Epilepsy-Intellectual Disability Syndrome, Type Finnish

    slow spike-and-wave discharges (1.5-2 Hz).[emedicine.medscape.com] Cerebral and cerebellar atrophy, dysmyelination, and corpus callosum hypoplasia are typical for all patients with SD [ 15 , 16 , 17 ].[link.springer.com] […] myoclonic jerks; (2) generalized tonic–clonic seizures; (3) mild neurologic signs in motor function or coordination; (4) photosensitivity, with generalized spike-and-wave[thieme-connect.com]

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