Epilepsy with Generalized Tonic-Clonic Seizures: Causes & Reasons

Possible Causes for Epilepsy with Generalized Tonic-Clonic Seizures

Juvenile myoclonic epilepsy carries a high risk of generalized tonic-clonic seizures. [emedicine.medscape.com]

The idiopathic generalized epilepsies are a group of primary generalized epilepsies with absence, myoclonic, and tonic-clonic seizures. [emedicine.medscape.com]

(eg, febrile convulsions, generalized tonic-clonic seizures). [emedicine.medscape.com]

Focal-Onset Impaired-Awareness Seizure

Epilepsy EEG shows generalized spike-wave activity May have a range of seizure types including absence, myoclonic, atonic, tonic and tonic-clonic seizures Idiopathic/Genetic [specialty.mims.com]

epilepsy, marked by loss of consciousness and generalized tonic convulsions followed by clonic convulsions. [medical-dictionary.thefreedictionary.com]

Generalized or Unknown Onset Tonic-Clonic seizures can occur if someone has generalized onset epilepsy and the seizure is a generalized seizure from the very start. [epilepsymaritimes.org]

Epilepsy

The majority of SUDEP cases occur in intractable epilepsy, especially in the aftermath of a generalized tonic-clonic seizure. [ncbi.nlm.nih.gov]

[…] with generalized tonic–clonic seizures only, European Journal of Paediatric Neurology, 18, 1, (13), (2014). [doi.org]

Risk factors for SUDEP include generalized tonic-clonic seizures, increased seizure frequency, concomitant learning disability, and antiepileptic drug polypharmacy. [ncbi.nlm.nih.gov]

Rolandic Epilepsy

Glauser, Long-term outcomes of generalized tonic-clonic seizures in a childhood absence epilepsy trial, Neurology, 85, 13, (1108), (2015). Jeffrey R. Tenney and Sejal V. [doi.org]

The disorder is marked clinically by nocturnal generalized tonic-clonic seizures and diurnal seizures consisting of simple partial seizures consisting of brief unilateral [clinicaltrials.gov]

generalized tonic-clonic seizures. [emedicine.com]

Meningeal Tuberculosis

Generalized tonic-clonic seizure Hydrocephalus Inhalation anthrax Normal pressure hydrocephalus (NPH) Pituitary tumor Reye syndrome Risks of lumbar puncture include: Bleeding [nlm.nih.gov]

Additional conditions under which the test may be performed: Chronic inflammatory polyneuropathy Dementia due to metabolic causes Encephalitis Epilepsy Febrile seizure (children [nlm.nih.gov]

Febrile Seizures

epilepsy with generalized tonic-clonic seizures (ICE-GTC), myoclonic astatic epilepsy (Doose syndrome), malignant migrating partial seizures of infancy, and familial hemiplegic [hindawi.com]

Type of Epilepsy Different types of seizures (generalized tonic clonic, absence, complex partial) may occur in those children who develop epilepsy after previous febrile seizures [indianpediatrics.net]

Examples of these syndromes include early infantile epileptic encephalopathy (Ohtahara syndrome), severe myoclonic epilepsy of infancy (Dravet syndrome), intractable childhood [hindawi.com]

Pallister W Syndrome

Self Limited Late Onset Occipital Epilepsy Gastaut Syndrome Epilepsy Generalized Tonic Clonic Seizures Alone Genetic Epilepsy with Febrile Seizures Plus Juvenile Absence [epilepsy.com]

[…] in Infancy Ohtahara Syndrome Panayiotopoulos Syndrome Progressive Myoclonic Epilepsies Reflex Epilepsies Self Limited Familial and Non-Familial Neonatal Infantile Seizures [epilepsy.com]

Febrile Infection-Related Epilepsy Syndrome Infantile Spasms (West Syndrome) Juvenile Myoclonic Epilepsy Landau-Kleffner Syndrome Lennox-Gastaut Syndrome (LGS) Myoclonic Epilepsy [epilepsy.com]

Alcohol Withdrawal Seizures

Some patients have generalized tonic-clonic seizures, usually not more than two in short succession (alcoholic epilepsy or rum fits). 1, record 1, English, - alcoholic%20epilepsy [btb.termiumplus.gc.ca]

Right as you are having your 11th beer, your eyes roll up and you have a big generalized tonic-clonic convulsion (see my posts on epilepsy on my website http://braindiseases.info [braindiseases.blog]

This kind of seizure which occurs at the height of binging is what has been referred to as a “rum” fit. I guess it was first described with respect to rum. [braindiseases.blog]

Stroke

Generalized absence seizures and tonic-clonic seizures are more frequent in children with OIRDA, and its presence in children with typical absence seems to be a good prognostic [scielo.br]

However, OIRDA seems related to the presence of epilepsy, especially generalized, in children 7,9. [scielo.br]

Alpers Syndrome

Seizures (mainly partial, secondary generalized tonic-clonic, or myoclonic) are often the presenting feature, evolving into focal status epilepticus, epilepsia partialis continua [orpha.net]

and/or multifocal myoclonic epilepsy. [orpha.net]

Seizures may respond to treatment initially but usually become intractable. [orpha.net]

Angelman Syndrome

Epilepsy is a common feature of Angelman syndrome (~80-90%), with the most common seizure types including myoclonic, atonic, atypical absence, focal, and generalized tonic-clonic [ncbi.nlm.nih.gov]

The later starts before the 3rd year of age in form of atypical absences, myoclonic and generalized tonic-clonic seizures. [osti.gov]

Epilepsy is characterized by atypical absences, erratic myoclonus, and occasional tonic-clonic seizures. [ncbi.nlm.nih.gov]

Infantile Neuronal Ceroid Lipofuscinosis

The myoclonic seizures generally improve during adulthood while other types of seizures, such as generalized tonic-clonic seizures, generally worsen throughout adulthood. [verywellhealth.com]

Many people who have JME also experience generalized tonic-clonic seizures (formerly called grand mal seizures). [verywellhealth.com]

Epilepsy, Progressive Myoclonus 2 (EPM2A), Lafora Disease This is a rare hereditary metabolic condition characterized by myoclonic seizures, generalized tonic-clonic seizures [verywellhealth.com]

Eclampsia

[…] presented at 25 weeks of pregnancy with generalized tonic clonic seizures. [ncbi.nlm.nih.gov]

tonic-clonic seizures followed by altered consciousness and very high blood pressure (HBP) of 240/120 mmHg, all of which started about 12 hours following a normal delivery [ncbi.nlm.nih.gov]

Gynaecology, Northwick Park Hospital, Northwest London NHS Trust, HA1 3UJ London, UK. ensteps@doctors.org.uk Abstract A 36-year-old primigravida with a history of temporal lobe epilepsy [ncbi.nlm.nih.gov]

Subarachnoid Hemorrhage

Mattson RH, Cramer JA, Collins JF A comparison of valproate with carbamazepine for the treatment of complex partial seizures and secondarily generalized tonic-clonic seizures [doi.org]

The Department of Veterans Affairs Epilepsy Cooperative Study No. 264 Group. N Engl J Med 1992;327:765–71. PubMed CrossRef Google Scholar 48. [doi.org]

Subacute Sclerosing Panencephalitis

Epilepsy was diagnosed in 21 (43%) patients. Among epileptic seizures excluding myoclonic jerks, generalized tonic-clonic type constituted the majority (58%). [ncbi.nlm.nih.gov]

[…] developed atonic seizures consisting of head drops, myoclonic seizures, and then generalized tonic clonic seizures lasting approximately two minutes. [ncbi.nlm.nih.gov]

Clinical report 2 A 14-year-old boy born in Canada presented in late 1997, at seven years of age, with staring spells, diagnosed as absence epilepsy but over the next year [ncbi.nlm.nih.gov]

Temporal Lobe Tumor

[…] will go on to experience a generalized tonic-clonic (grand mal) seizure, which causes convulsions and a loss of consciousness. [healthline.com]

The most common risk factor for temporal lobe epilepsy is having had a seizure, especially an unusually long-lasting seizure, with a fever at some point in life. [healthline.com]

[…] temporal lobe seizure occurs, you may experience: trouble speaking confusion being unaware a seizure occurred intense fatigue Rarely, people who experience a temporal lobe seizure [healthline.com]

Binswanger Disease

(JME) primary generalized epilepsy syndrome usually beginning between ages 5 to 17 years, characterized by myoclonic (muscle-jerk), absence, and tonic-clonic seizures Kernig [strokecenter.org]

[…] variability of potentials of two muscle fibers innervated by an individual axon as measured by single fiber electromyography ; increased in myasthenia gravis juvenile myoclonic epilepsy [strokecenter.org]

Wolf-Hirschhorn Syndrome

Sixty out of 81 (74%) had generalized tonic-clonic seizures, which was the only seizure pattern in 32. [ncbi.nlm.nih.gov]

Seizure patterns were generalized tonic-clonic in 74%, tonic spasms in 18%, complex partial in 12%, and clonic in 7%. [pediatricneurologybriefs.com]

Epilepsy occurred in 81 patients (93%) within the first 3 years of life. [ncbi.nlm.nih.gov]

Menkes Disease

During the follow-up, patients showed multiple seizure types: 6 patients had generalized tonic clonic seizures (GCT), 6 patients presented IS, 10 children had FS, 11 had myoclonic [ncbi.nlm.nih.gov]

RESULTS: The large majority of our patients presented at the onset of epilepsy focal seizures (FS) and infantile spasms (IS). [ncbi.nlm.nih.gov]

Pseudohypoparathyroidism

The patient was diagnosed with epilepsy at 13 years of age after an episode of generalized tonic-clonic seizure and therapeutic failure with valproic acid, gabapentin and [revistas.unal.edu.co]

Acute Intermittent Porphyria

Teratoma-negative anti-NMDA receptor encephalitis presenting with a single generalized tonic–clonic seizure Abstract: Publication date: 2018Source: Epilepsy & Behavior Case [journaltocs.ac.uk]

tonic–clonic seizure and prominent psychiatric symptoms. [journaltocs.ac.uk]

MirsattariAbstractHerein, we describe a case report of anti-NMDA receptor encephalitis characterized by a single generalized tonic–clonic seizure and predominantly psychiatric [journaltocs.ac.uk]

Adams-Stokes Syndrome

Our patient presented with repetitive convulsions, loss of consciousness, generalized tonic and clonic spasms that mimic epileptic seizure. [egetipdergisi.com.tr]

However, if we begin treating patients who have cardiac syncope with a misdiagnosis of epilepsy, diphenylhydantoin can be a bad choice since diphenylhydantoin or lidocaine [egetipdergisi.com.tr]

Syndrome of Inappropriate Antidiuretic Hormone Secretion

He has had generalized tonic clonic seizures sometimes in a year, and often seizures like myoclonia. [ci.nii.ac.jp]

He has a severe mental retardation and eight years old on-set epilepsy. [ci.nii.ac.jp]

Tuberous Sclerosis

If they spread to involve a large enough area of the brain, partial seizures can turn into a generalized tonic-clonic seizure. [my.clevelandclinic.org]

Epilepsy, if poorly controlled, can have devastating consequences on the patient's and family's quality of life. [my.clevelandclinic.org]

Stevens-Johnson Syndrome

A comparison of valproate with carbamazepine for the treatment of complex partial seizures and secondarily generalized tonic-clonic seizures in adults. [nejm.org]

Mattson RH, Cramer JA, Collins JF, Department of Veterans Affairs Epilepsy Cooperative Study No. 264 Group. [nejm.org]

Neurocysticercosis

The epileptic seizures were classified as secondary generalized partial seizures (symptomatic partial epilepsy secondary to CC). [omicsonline.org]

The main symptoms were analyzed: the three most important, in order, were tonic-clonic convulsions, HA and motor deficit respectively. [omicsonline.org]

In Cuba, the correlation between disease and epilepsy (4 of 5 cases) was assessed. [omicsonline.org]

Anticonvulsant

Primary generalized tonic-clonic seizures in patients 6 years of age and older with idiopathic generalized epilepsy. [globalrph.com]

A comparison of valproate with carbamazepine for the treatment of complex partial seizures and secondarily generalized tonic-clonic seizures in adults. [doi.org]

[…] or without secondarily generalized seizures in patients with epilepsy 12 years of age and older (1.1) Primary Generalized Tonic-Clonic Seizures in patients with epilepsy [globalrph.com]

Alcohol Abuse

RATIONALE: Low-income Coloured Western Cape communities in South Africa display high rates of problematic drinking, especially binge-drinking over weekends. Alcohol abuse in these communities is linked to the prevalence of intimate partner violence (IPV), fetal alcohol syndrome and sexual violence against women. Few[…] [ncbi.nlm.nih.gov]

Hypoglycemia

A 71-year-old woman previously diagnosed with reactive hypoglycemia was transferred to our emergency unit because of loss of consciousness. Her plasma glucose level was 27 mg/dL, and continuous glucose monitoring (CGM) revealed postprandial asymptomatic hypoglycemia. A hypervascular tumor was identified via[…] [ncbi.nlm.nih.gov]

Chronic Alcoholism

Of five chronic alcoholics with acute skeletal muscle necrosis (rhabdomyolysis) three developed acute heart failure with disturbances of rhythm and conduction. Symptoms came on abruptly after a period of intensified drinking. Myocardial infarction, thiamine deficiency, and cobalt intoxication were excluded. Probably[…] [ncbi.nlm.nih.gov]