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160 Possible Causes for Genetic Heterogeneity, Increased Ankle Reflex

  • Hereditary Spastic Paraplegia

    […] of deep tendon reflexes in the legs, loss of ankle flexibility, and decrease of sensation in the legs.[encyclopedia.com] HSP is a clinically and genetically heterogeneous neurodegenerative disorder characterized by degeneration of the corticospinal tract motor neurons and resulting in progressive[ncbi.nlm.nih.gov] Deep tendon reflexes are pathologically increased (3 to 4 ) in the lower extremities.[slideshare.net]

  • Spastic Paraplegia

    […] of deep tendon reflexes in the legs, loss of ankle flexibility, and decrease of sensation in the legs.[encyclopedia.com] Complex forms of spastic paraplegia (SPG) are rare and genetically heterogeneous.[ncbi.nlm.nih.gov] HSP is a clinically and genetically heterogeneous disorder of the upper motor neurons. Symptoms beginning in early childhood may resemble spastic cerebral palsy.[ncbi.nlm.nih.gov]

  • Stroke

    genetic model (GG   GT vs TT).[ncbi.nlm.nih.gov] Heterogeneity was assessed by using Q test and I test. Publication bias was evaluated by using Egger method.[ncbi.nlm.nih.gov] Four gene models were analyzed including, allele genetic model (G vs T), additive genetic model (GG vs TT, GT vs TT), recessive genetic model (GG vs GT   TT), and dominant[ncbi.nlm.nih.gov]

  • Upper Motor Neuron Disease

    […] tone bilaterally, pyramidal weakness bilaterally, increased knee reflexes, upgoing plantars and clonus) Absent ankle reflexes Tongue wasting and fasciculations Increased[medicaleducationleeds.com] Turner and others 2013 ....with profound clinical, prognostic, neuropathological, and now genetic heterogeneity, the concept of ALS as one disease appears increasingly untenable[mndcare.net.au] Both disorders are genetically heterogeneous.[emedicine.medscape.com]

  • Hyperthyroidism

    Kallmann syndrome (KS) is a clinically and genetically heterogeneous disorder characterized by hypogonadotropic hypogonadism and olfactory dysfunction.[ncbi.nlm.nih.gov]

  • Primary Progressive Multiple Sclerosis

    Heterogeneity at the HLA-DRB1 locus and risk for multiple sclerosis.[journal.frontiersin.org] Hum Mol Genet (2006) 15(18):2813–24. doi:10.1093/hmg/ddl223 PubMed Abstract CrossRef Full Text Google Scholar 8.[journal.frontiersin.org]

  • Subacute Transverse Myelitis

    Muscle tone was slightly increased in the lower limbs. There was no clonus. Deep tendon reflexes were traced in the upper extremities, 2 at the knees, 2 at the ankles.[egms.de] Introduction Acute transverse myelitis (ATM) is a patho-genetically heterogeneous inflammatory disorder characterized by focal inflammation of spinal cord and resultant neuronal[jpma.org.pk] Our data suggested that the severity of motor impairment is greater in our population than that reported in western literature which might hint to different genetic or environmental[jpma.org.pk]

  • Cerebral Cortical Atrophy

    Learn more Other less relevant matches: Medium match CONGENITAL DISORDER OF GLYCOSYLATION, TYPE In; CDG1N Congenital disorders of glycosylation (CDGs) are a genetically heterogeneous[mendelian.co] Biochemical studies show deficiencies of multiple mitochondrial respiratory enzymes (summary by Garcia-Diaz et al., 2012 ).For a discussion of genetic heterogeneity of combined[mendelian.co] Genetic Heterogeneity of Mitochondrial Complex V DeficiencyOther nuclear types of mitochondrial complex V deficiency include MC5DN2 ( OMIM ), caused by mutation in the TMEM70[mendelian.co]

  • Myelopathy

    , Deep tendon reflexes in the knee and ankle will be accentuated (hyperreflexia), Forced extension of the ankle may cause the foot to beat up and down rapidly (clonus), Scratching[necksolutions.com] Hereditary spastic paraplegia (also called familial spastic paraplegia or Strumpell-Lorrain disease) is not a single disease, but rather a heterogeneous group of genetic disorders[massagetoday.com] […] retardation) – 1 Serious urination difficulty (residual urine, dysuria) – 0 Urine retention Additional findings associated with myelopathy: Muscular tone in the legs will be increased[necksolutions.com]

  • Hypocalcemia

    ADH is genetically heterogeneous with ADH type 1 (ADH1), the predominant form, being caused by germline gain-of-function mutations of the G-protein coupled calcium-sensing[ncbi.nlm.nih.gov] Such “pseudohypoparathyroidism” is caused by failure of parathyroid hormone to activate its signalling pathways. 8 Pseudohypoparathyroidism is a genetically heterogeneous[doi.org]

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