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160 Possible Causes for Genetic Heterogeneity, Increased Ankle Reflex

  • Hereditary Spastic Paraplegia

    […] of deep tendon reflexes in the legs, loss of ankle flexibility, and decrease of sensation in the legs.[] HSP is a clinically and genetically heterogeneous neurodegenerative disorder characterized by degeneration of the corticospinal tract motor neurons and resulting in progressive[] Deep tendon reflexes are pathologically increased (3 to 4 ) in the lower extremities.[]

  • Spastic Paraplegia

    […] of deep tendon reflexes in the legs, loss of ankle flexibility, and decrease of sensation in the legs.[] Complex forms of spastic paraplegia (SPG) are rare and genetically heterogeneous.[] HSP is a clinically and genetically heterogeneous disorder of the upper motor neurons. Symptoms beginning in early childhood may resemble spastic cerebral palsy.[]

  • Stroke

    genetic model (GG   GT vs TT).[] Heterogeneity was assessed by using Q test and I test. Publication bias was evaluated by using Egger method.[] Four gene models were analyzed including, allele genetic model (G vs T), additive genetic model (GG vs TT, GT vs TT), recessive genetic model (GG vs GT   TT), and dominant[]

  • Upper Motor Neuron Disease

    […] tone bilaterally, pyramidal weakness bilaterally, increased knee reflexes, upgoing plantars and clonus) Absent ankle reflexes Tongue wasting and fasciculations Increased[] Turner and others 2013 ....with profound clinical, prognostic, neuropathological, and now genetic heterogeneity, the concept of ALS as one disease appears increasingly untenable[] Both disorders are genetically heterogeneous.[]

  • Hyperthyroidism

    Kallmann syndrome (KS) is a clinically and genetically heterogeneous disorder characterized by hypogonadotropic hypogonadism and olfactory dysfunction.[]

  • Primary Progressive Multiple Sclerosis

    Heterogeneity at the HLA-DRB1 locus and risk for multiple sclerosis.[] Hum Mol Genet (2006) 15(18):2813–24. doi:10.1093/hmg/ddl223 PubMed Abstract CrossRef Full Text Google Scholar 8.[]

  • Subacute Transverse Myelitis

    Muscle tone was slightly increased in the lower limbs. There was no clonus. Deep tendon reflexes were traced in the upper extremities, 2 at the knees, 2 at the ankles.[] Introduction Acute transverse myelitis (ATM) is a patho-genetically heterogeneous inflammatory disorder characterized by focal inflammation of spinal cord and resultant neuronal[] Our data suggested that the severity of motor impairment is greater in our population than that reported in western literature which might hint to different genetic or environmental[]

  • Cerebral Cortical Atrophy

    Learn more Other less relevant matches: Medium match CONGENITAL DISORDER OF GLYCOSYLATION, TYPE In; CDG1N Congenital disorders of glycosylation (CDGs) are a genetically heterogeneous[] Biochemical studies show deficiencies of multiple mitochondrial respiratory enzymes (summary by Garcia-Diaz et al., 2012 ).For a discussion of genetic heterogeneity of combined[] Genetic Heterogeneity of Mitochondrial Complex V DeficiencyOther nuclear types of mitochondrial complex V deficiency include MC5DN2 ( OMIM ), caused by mutation in the TMEM70[]

  • Myelopathy

    , Deep tendon reflexes in the knee and ankle will be accentuated (hyperreflexia), Forced extension of the ankle may cause the foot to beat up and down rapidly (clonus), Scratching[] Hereditary spastic paraplegia (also called familial spastic paraplegia or Strumpell-Lorrain disease) is not a single disease, but rather a heterogeneous group of genetic disorders[] […] retardation) – 1 Serious urination difficulty (residual urine, dysuria) – 0 Urine retention Additional findings associated with myelopathy: Muscular tone in the legs will be increased[]

  • Hypocalcemia

    ADH is genetically heterogeneous with ADH type 1 (ADH1), the predominant form, being caused by germline gain-of-function mutations of the G-protein coupled calcium-sensing[] Such “pseudohypoparathyroidism” is caused by failure of parathyroid hormone to activate its signalling pathways. 8 Pseudohypoparathyroidism is a genetically heterogeneous[]

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