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11 Possible Causes for Genetic Heterogeneity, Series of Focal Spikes

  • Benign Adult Familial Myoclonic Epilepsy

    Abstract Benign adult familial myoclonic epilepsy (BAFME) has been mapped to chromosome 8q24; however, genetic heterogeneity has been recently suggested.[ncbi.nlm.nih.gov] This observation would confirm that BAFME is a worldwide, genetically heterogeneous condition, probably with Japanese families linked to 8q24 and European families to 2p11.1[ncbi.nlm.nih.gov] April 22, 2003 ; 60 (8) Brief Communications Genetic heterogeneity and allelism with ADCME F.A. de Falco , P. Striano , A. de Falco , S. Striano , R. Santangelo , A.[neurology.org]

  • Juvenile Myoclonic Epilepsy

    BACKGROUND: Juvenile myoclonic epilepsy (JME), is an early-onset inherited generalized epilepsy which displays genetic heterogeneity, with at least 10 known loci.[ncbi.nlm.nih.gov] Abstract Juvenile myoclonic epilepsy (JME) is a clinically and genetically heterogenous, generalized epilepsy syndrome usually starting in adolescence.[ncbi.nlm.nih.gov] heterogeneity is suspected.[pmj.bmj.com]

  • Epilepsy

    Progressive myoclonic epilepsies (PME) are a clinically and genetically heterogeneous group of rare diseases characterized by myoclonic seizures, tonic-clonic seizures, and[ncbi.nlm.nih.gov] This observation along with our previous findings of hot water genetic loci at 10q21.3-q22.3 (OMIM: 613339) and 4q24-q28 (OMIM: 613340), indicates unanticipated genetic heterogeneity[ncbi.nlm.nih.gov] Due to clinical and genetic heterogeneity of PMEs, it is difficult to decide which genes are affected.[ncbi.nlm.nih.gov]

  • Idiopathic Generalized Epilepsy

    The lack of significant association evidence of single variants with disease in this two-stage approach emphasizes the high genetic heterogeneity of epilepsy disorders, suggests[ncbi.nlm.nih.gov] Genetic Heterogeneity of Idiopathic Generalized Epilepsy EIG1 has been mapped to chromosome 8q24.[diseaseinfosearch.org] Molecular genetic analyses have led to important breakthroughs in the identification of candidate genes and loci; genetic heterogeneity is common.[epilepsy.com]

  • Generalized Clonic or Tonic-Clonic Seizures

    Genetic Heterogeneity of Progressive Myoclonic EpilepsyProgressive myoclonic epilepsy refers to a clinically and genetically heterogeneous group of neurodegenerative disorders[mendelian.co] […] description and a discussion of genetic heterogeneity of early infantile epileptic encephalopathy, see EIEE1 ( OMIM ).[mendelian.co] Genetic Heterogeneity of Familial Adult Myoclonic EpilepsyFAME1 maps to chromosome 8q24; FAME2 ( OMIM ) is caused by mutation in the ADRA2B gene ( OMIM ) on chromosome 2q11[mendelian.co]

  • West Syndrome

    West syndrome is genetically heterogeneous, and its genetic causes have not been fully elucidated.[ncbi.nlm.nih.gov] This disorder is genetically heterogeneous, with up to a fifth of cases resulting from mutations in the CDKL5 gene.[genedx.com] Identification of genetic associations of IS, a rapidly developing area, suggests IS is a genetically heterogeneous condition involving abnormalities in key developmental[ncbi.nlm.nih.gov]

  • Juvenile Absence Epilepsy

    Página 112 - JC (1998) Autosomal dominant nocturnal frontal-lobe epilepsy: genetic heterogeneity and evidence for a second locus at 15q24. Am. J. Hum.[books.google.es] heterogeneous.[onlinelibrary.wiley.com] Although JME cases are genetically heterogeneous, patients within those various groups are not clinically distinguished by the current diagnostic methods 11.[scielo.br]

  • Neonatal Seizures

    We thus conclude that benign familial neonatal seizures is a genetically heterogeneous type of epilepsy.[ncbi.nlm.nih.gov] Genetic heterogeneity in benign familial neonatal convulsions: identification of a new locus on chromosome 8q.[ncbi.nlm.nih.gov] Benign familial neonatal convulsions: evidence for clinical and genetic heterogeneity. Ann Neurol. 1991; 29 :469–73. [ PubMed : 1859177 ] 85.[ncbi.nlm.nih.gov]

  • Early Myoclonic Encephalopathy

    For a general phenotypic description and a discussion of genetic heterogeneity of EIEE, see EIEE1 ({308350}).[diseaseinfosearch.org] This syndrome is likely to be the earliest age-related specific epileptic reaction of the developing brain to heterogeneous insults Neonatal epileptic seizures - Genetic testing[brainscape.com]

  • Lennox-Gastaut Syndrome

    On the contrary, he found that spike-wave complexes appeared in bursts, in isolated form or even focal, with a gradual tendency to the normalization of EEG basic rhythms [[omicsonline.org] There is no single gene for IS or LGS, but the genetic architecture is heterogeneous.[epilepsygenetics.net] Evaluation of the clinical phenotypes among patients revealed significant genetic heterogeneity underlying IS and LGS, and begins to provide information about the range of[ncbi.nlm.nih.gov]

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