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12 Possible Causes for Genu Valgum, Hemolysis, Some Patients May Be Clinically Asymptomatic

  • Hypophosphatemia

    23 pathway (such as hypophosphatemic rickets), hypophosphatemia is a frequent condition encountered in daily practice, and untreated critical hypophosphatemia can induce hemolysis[ncbi.nlm.nih.gov] The absence of short stature and lower limb deformities in some of these patients suggest a not so intense hypophosphatemia during infancy and childhood (53).[scielo.br] In infants and children, the signs and symptoms include: Abnormal "waddling" walk due to knock-knees (genu valgum) or bowed legs (genu varum) Thick wrists Ribs of the chest[dovemed.com]

  • Glycogen Storage Disease due to Glucose-6-Phosphat Transport Defect

    […] and a marker of hemolytic severity) Haptoglobin (decreased in hemolysis); A " direct antiglobulin test " (Coombs' test) – this should be negative, as hemolysis in G6PD is[ipfs.io] Related to Increased sarcoplasmic Ca Myalgia Myoglobinuria : Some patients; With intense exercise Strength: Normal Clinical course: Benign Treatment: Dantrolene may reduce[neuromuscular.wustl.edu] Mental retardation, ectopia lentis, sparse blond hair, genu valgum, failure to thrive, thromboembolic episodes, fatty changes of liver.[kumc.edu]

  • Glycogen Storage Disease due to Phosphoglycerate Mutase Deficiency

    GSD VII (Tarui disease; 232800) Phosphofructokinase PFKM (12q13.3)* Onset: Middle childhood Clinical features: Exercise intolerance due to muscle cramps, rhabdomyolysis, hemolysis[msdmanuals.com] valgum Situs inversus totalis Developmental regression Corneal opacity Joint hyperflexibility Attention deficit hyperactivity disorder Broad forehead Small for gestational[mendelian.co] Related to Increased sarcoplasmic Ca Myalgia Myoglobinuria : Some patients; With intense exercise Strength: Normal Clinical course: Benign Treatment: Dantrolene may reduce[neuromuscular.wustl.edu]

  • Glycogen Storage Disease due to GLUT2 Deficiency

    "Hereditary nonspherocytic hemolysis with erythrocyte phosphofructokinase deficiency". Blood. 39 (3): 415–25. PMID 4258222.[wikidoc.org] Related to Increased sarcoplasmic Ca Myalgia Myoglobinuria : Some patients; With intense exercise Strength: Normal Clinical course: Benign Treatment: Dantrolene may reduce[neuromuscular.wustl.edu] Genu valgum, st. Helena familial[?] Genu varum[?] Genuphobia[?] Geographic tongue[?] German syndrome[?] Germinal cell aplasia[?] Gerodermia osteodysplastica[?][encyclopedia.kids.net.au]

  • Glycogen Storage Disease

    Compensated hemolysis (increased bilirubin and reticulocytes) and hyperuricemia are associated. A rapidly fatal infant form has also been observed in 6 families.[orpha.net] Intervention with custom-molded foot orthoses may improve distal alignment at feet and ankles and secondarily decrease genu valgum, leading to improved weight-bearing alignment[nature.com] Related to Increased sarcoplasmic Ca Myalgia Myoglobinuria : Some patients; With intense exercise Strength: Normal Clinical course: Benign Treatment: Dantrolene may reduce[neuromuscular.wustl.edu]

  • Glycogen Storage Disease Type 2

    Kreuder J, Borkhardt A, Repp R, Pekrun A, Gottsche B, Gottschalk U, Reichmann H, Schachenmayr W, Schlegel K, Lampert F Title Brief report: inherited metabolic myopathy and hemolysis[genome.jp] Related to Increased sarcoplasmic Ca Myalgia Myoglobinuria : Some patients; With intense exercise Strength: Normal Clinical course: Benign Treatment: Dantrolene may reduce[neuromuscular.wustl.edu] Intervention with custom-molded foot orthoses may improve distal alignment at feet and ankles and secondarily decrease genu valgum, leading to improved weight-bearing alignment[nature.com]

  • Congenital Absence of Ductus Arteriosus

    Complications include distortion of flow in the proximal part of the left pulmonary artery, hemolysis resulting from high –speed residual shunting, vein thrombosis, and infection[lecturio.com] , some of these anomalies may lead to various clinical symptoms such as recurrent abdominal pain, nausea and vomiting.[synapse.koreamed.org] : valgum varum Rudimentary patella Excl.: congenital: dislocation of knee (Q68.2) genu recurvatum (Q68.2) nail patella syndrome (Q87.2) Q74.2 Other congenital malformations[embryology.med.unsw.edu.au]

  • Hereditary Cryohydrocytosis with Normal Stomatin

    Heterozygotes have little or no hemolysis or anemia except in the neonatal period when jaundice and mild hemolysis and anemia are common.[cancertherapyadvisor.com] The vast majority of patients with HE are asymptomatic, and only about 10% have moderate to severe anemia. 11 Some may have a mild compensated hemolytic anemia as evidenced[doctorlib.info] valgum 2946 Brachydactyly - long thumb 2865 Short stature - webbed neck - heart disease 4 Cases 4 Cases 94095 2919 Orofaciodigital syndrome type 5 2820 Spastic paraplegia[slidex.tips]

  • Beta-Ureidopropionase Deficiency

    It produces partial hemolysis of sheep and cattle erythrocytes. It appears to have little pathogenic effect.[medical-dictionary.thefreedictionary.com] The clinical phenotypes of this condition are variable; some patients were asymptomatic while some may present with developmental delay or autistic features.[ncbi.nlm.nih.gov] valgum Spondylometaphyseal dysplasia, 'corner fracture' type Spondylometaphyseal dysplasia, Algerian type Spondylometaphyseal dysplasia, Kozlowski type Spondylometaphyseal[csbg.cnb.csic.es]

  • Glycogen Storage Disease due to Aldolase A Deficiency

    "Brief Report: Inherited Metabolic Myopathy and Hemolysis Due to a Mutation in Aldolase A".[en.wikipedia.org] Related to Increased sarcoplasmic Ca Myalgia Myoglobinuria : Some patients; With intense exercise Strength: Normal Clinical course: Benign Treatment: Dantrolene may reduce[neuromuscular.wustl.edu] Mental retardation, ectopia lentis, sparse blond hair, genu valgum, failure to thrive, thromboembolic episodes, fatty changes of liver.[kumc.edu]

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