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14 Possible Causes for Genu Valgum, Hypomagnesemia, Some Patients May Be Clinically Asymptomatic

  • Vitamin D Deficiency

    However, severe vitamin D deficiency may manifest as rickets with the below clinical features: Bony Signs - Swelling of wrists and ankles - Leg deformities (genu varum or[starship.org.nz] It is imperative to consider that some patients, such as our patient described in this report, may be previously asymptomatic clinically and on the basis of laboratory findings[ncbi.nlm.nih.gov] Electrolyte Imbalance [2] Often associated with hypomagnesemia Hyperparathyroidism Parathyroid hormone (PTH) is a key hormone that regulates renal synthesis of calcidiol or[physio-pedia.com]

  • Primary Hyperparathyroidism

    On examination she had bilateral genu valgum.[ncbi.nlm.nih.gov] It is imperative to consider that some patients, such as our patient described in this report, may be previously asymptomatic clinically and on the basis of laboratory findings[ncbi.nlm.nih.gov] Even asymptomatic PHPT patients display clinical improvement in some symptoms a year following PTx, particularly patients with higher preoperative calcium levels ( 2.6 mmol[link.springer.com]

  • Hypophosphatemia

    In infants and children, the signs and symptoms include: Abnormal "waddling" walk due to knock-knees (genu valgum) or bowed legs (genu varum) Thick wrists Ribs of the chest[dovemed.com] The absence of short stature and lower limb deformities in some of these patients suggest a not so intense hypophosphatemia during infancy and childhood (53).[scielo.br] Hypokalemia and hypomagnesemia commonly complicate refeeding syndrome as well; however, this report briefly reviews the clinical manifestations of refeeding-induced hypophosphatemia[ncbi.nlm.nih.gov]

  • Osteomalacia

    Bowing of the legs (genu varum) is typical, but knock knees (genu valgum) can also occur.[patient.info] The absence of short stature and lower limb deformities in some of these patients suggest a not so intense hypophosphatemia during infancy and childhood (53).[scielo.br] Additional assessments of the patient revealed not only hypocalcemia, but also hypophosphatemia, hypomagnesemia, osteomalacia, and a high concentration of fibroblast growth[ncbi.nlm.nih.gov]

  • Autosomal Dominant Hypocalcemia Type 1

    Some adult patients with the disorder may have elevated aldosterone levels, but no history of clinical disease.[diseaseinfosearch.org] Hypomagnesemia Magnesium is essential for PTH release.[clinicaladvisor.com] Genu valgum (knock knees) may occur as well as the more typical genu varum (bow legged) appearance.[adc.bmj.com]

  • Glycogen Storage Disease due to Glucose-6-Phosphat Transport Defect

    Related to Increased sarcoplasmic Ca Myalgia Myoglobinuria : Some patients; With intense exercise Strength: Normal Clinical course: Benign Treatment: Dantrolene may reduce[neuromuscular.wustl.edu] hypomagnesemia with normocalciuria and normocalcemia Familial primary hypomagnesemia with normocalcuria Familial renal glucosuria Farber disease Fatal infantile cytochrome[se-atlas.de] Mental retardation, ectopia lentis, sparse blond hair, genu valgum, failure to thrive, thromboembolic episodes, fatty changes of liver.[kumc.edu]

  • Glycogen Storage Disease due to GLUT2 Deficiency

    Genu valgum, st. Helena familial[?] Genu varum[?] Genuphobia[?] Geographic tongue[?] German syndrome[?] Germinal cell aplasia[?] Gerodermia osteodysplastica[?][encyclopedia.kids.net.au] Related to Increased sarcoplasmic Ca Myalgia Myoglobinuria : Some patients; With intense exercise Strength: Normal Clinical course: Benign Treatment: Dantrolene may reduce[neuromuscular.wustl.edu] Familial primary hypomagnesemia with hypocalcuria Gitelman syndrome Familial primary hypomagnesemia with normocalcuria Familial primary hypomagnesemia with normocalcuria[repository.innermed.eu]

  • Glycogen Storage Disease due to Phosphoglycerate Mutase Deficiency

    Related to Increased sarcoplasmic Ca Myalgia Myoglobinuria : Some patients; With intense exercise Strength: Normal Clinical course: Benign Treatment: Dantrolene may reduce[neuromuscular.wustl.edu] […] type 1 TRPM6 Hypomagnesemia type 2 FXYD2 Hypomagnesemia type 3 CLDN16 Hypomagnesemia type 4 EGF Hypomagnesemia type 5 CLDN19 Hypomagnesemia type 6 CNNM2 Hypophosphatasia,[centogene.com] valgum Situs inversus totalis Developmental regression Corneal opacity Joint hyperflexibility Attention deficit hyperactivity disorder Broad forehead Small for gestational[mendelian.co]

  • Glycogen Storage Disease Type 2

    Intervention with custom-molded foot orthoses may improve distal alignment at feet and ankles and secondarily decrease genu valgum, leading to improved weight-bearing alignment[nature.com] Related to Increased sarcoplasmic Ca Myalgia Myoglobinuria : Some patients; With intense exercise Strength: Normal Clinical course: Benign Treatment: Dantrolene may reduce[neuromuscular.wustl.edu] Thoracic vertebral fracture was reported in the case study of an adult patient with late onset disease who had osteopenia, hypomagnesemia, hypocalcemia, and hypocalciuria.[dx.doi.org]

  • Beta-Ureidopropionase Deficiency

    valgum Spondylometaphyseal dysplasia, 'corner fracture' type Spondylometaphyseal dysplasia, Algerian type Spondylometaphyseal dysplasia, Kozlowski type Spondylometaphyseal[csbg.cnb.csic.es] The clinical phenotypes of this condition are variable; some patients were asymptomatic while some may present with developmental delay or autistic features.[ncbi.nlm.nih.gov] Familial primary hypomagnesemia with hypocalcuria Gitelman syndrome Familial primary hypomagnesemia with normocalcuria Familial primary hypomagnesemia with normocalcuria[repository.innermed.eu]

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