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2,020 Possible Causes for Genu Valgum, Osteopenia and Osteoporosis, Some Patients May Be Clinically Asymptomatic

  • Vitamin D Deficiency

    It is imperative to consider that some patients, such as our patient described in this report, may be previously asymptomatic clinically and on the basis of laboratory findings[ncbi.nlm.nih.gov] However, severe vitamin D deficiency may manifest as rickets with the below clinical features: Bony Signs - Swelling of wrists and ankles - Leg deformities (genu varum or[starship.org.nz] Severe, prolonged vitamin D deficiency causes growth retardation and rickets in children and osteomalacia, osteopenia, and osteoporosis in adults.[bestpractice.bmj.com]

  • Osteomalacia

    The absence of short stature and lower limb deformities in some of these patients suggest a not so intense hypophosphatemia during infancy and childhood (53).[scielo.br] Bowing of the legs (genu varum) is typical, but knock knees (genu valgum) can also occur.[patient.info] Its causes are the same as those for Osteopenia (milder form of bone loss that usually precedes Osteoporosis.)[osteopenia3.com]

  • Cooley's Anemia

    In uncomplicated cases, skeletal deformities include genu valgum, frontal bossing, malar bone prominence, depression of the nasal bridge, and maxillae hypertrophy.[symptoma.com] […] and osteoporosis.[pathophys.org] Untreated or poorly transfused patients show growth retardation, pallor, jaundice, poor musculature, genu valgum, leg ulcers, formation of masses due to extramedullary hematopoiesis[orpha.net]

    Missing: Some Patients May Be Clinically Asymptomatic
  • Mucopolysaccharidosis

    valgum, waddling gait, and laxity of joints.[ncbi.nlm.nih.gov] Abstract A 16-year-old boy with widening of the large joints of the extremities and bilateral genu valgum had been extensively treated with oral vitamin D, with little clinical[ncbi.nlm.nih.gov] valgum, short stature, spinal curvature, odontoid hypoplasia, ligamentous laxity, and atlantoaxial instability MPS IV (mild) – Much slower progression of skeletal dysplasia[emedicine.medscape.com]

    Missing: Some Patients May Be Clinically Asymptomatic
  • Marfan Syndrome

    The Marfan syndrome is an inherited disorder of the connective tissue which is mainly caused by a mutation in the fibrillin-1 gene. The defect in the connective tissue protein can lead to several organ dysfunctions. For the life expectancy, the cardiovascular aspect is of paramount importance. Patients with Marfan[…][ncbi.nlm.nih.gov]

    Missing: Some Patients May Be Clinically Asymptomatic
  • Familial Hypophosphatemia

    Chronic and more severe forms of hypophosphatemia present with bone pain, osteomalacia and pseudofractures, rachitis-like characteristics (genu valgum, frontal bossing, widening[symptoma.com] osteopenia (in 100 percent of patients with celiac disease) Dental enamel defects Short stature Arthritis or arthralgia (central arthritis-sacroiliitis in 63 percent of patients[aafp.org] In infants and children, the signs and symptoms include: Abnormal "waddling" walk due to knock-knees (genu valgum) or bowed legs (genu varum) Thick wrists Ribs of the chest[dovemed.com]

    Missing: Some Patients May Be Clinically Asymptomatic
  • Primary Hyperparathyroidism

    It is imperative to consider that some patients, such as our patient described in this report, may be previously asymptomatic clinically and on the basis of laboratory findings[ncbi.nlm.nih.gov] On examination she had bilateral genu valgum.[ncbi.nlm.nih.gov] This leads to porous, brittle bones known as osteopenia and osteoporosis.[healthcentral.com]

  • Aromatase Deficiency

    The pubertal growth spurt is absent, but linear growth continues due to incomplete epiphyseal closure and progressive genu valgum, eunuchoid proportion of the skeleton and[orpha.net] Estrogen deficiency can induce delayed epiphyseal closure, eunuchoid body habitus, osteopenia, and osteoporosis in both genders.[ncbi.nlm.nih.gov] valgum.[genedx.com]

    Missing: Some Patients May Be Clinically Asymptomatic
  • Mucopolysaccharidosis 4A

    MPS-IVA commonly manifests in form of kyphosis or gibbus, scoliosis, pectus carinatum, genu valgum, gait disturbances and frequent falls, but the clinical presentation varies[symptoma.com] In our study, according to BMD assessment by DXA, a half of MPS IVA patients had osteopenia or osteoporosis.[ojrd.biomedcentral.com] Skeletal deformities (platyspondyly, kyphosis, scoliosis, pectus carinatum , genu valgum , long bone deformities) become more pronounced as the child grows.[orpha.net]

    Missing: Some Patients May Be Clinically Asymptomatic
  • Pseudoachondroplasia

    Legs are malaligned with a variety of knee deformities noted, including bow-legs (genu varum), knock-knees (genu valgum), and windswept deformities (bow-leg on one side and[web.archive.org] […] syndrome with osteopenia 骨減少症を伴う高IgE症候群 Idiopathic juvenile osteoporosis 特発性若年性骨粗しょう症 24.Dysplasias with defective mineralization 24.骨石灰化障害を伴う骨異形成症 Hypophosphatasia-perinatal[normanet.ne.jp] […] varum, genu valgum, or genu recurvatum underwent surgical correction.[appliedradiology.com]

    Missing: Some Patients May Be Clinically Asymptomatic

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