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1,645 Possible Causes for Genu Valgum, Parathyroid Hormone Increased, Some Patients May Be Clinically Asymptomatic

  • Vitamin D Deficiency

    It is imperative to consider that some patients, such as our patient described in this report, may be previously asymptomatic clinically and on the basis of laboratory findings[ncbi.nlm.nih.gov] Cross sectional studies demonstrated that prevalence of HF is increased in patients with Vitamin D deficiency or parathyroid hormone (PTH) plasma level increase, whereas longitudinal[ncbi.nlm.nih.gov] However, severe vitamin D deficiency may manifest as rickets with the below clinical features: Bony Signs - Swelling of wrists and ankles - Leg deformities (genu varum or[starship.org.nz]

  • Familial Hypophosphatemia

    Chronic and more severe forms of hypophosphatemia present with bone pain, osteomalacia and pseudofractures, rachitis-like characteristics (genu valgum, frontal bossing, widening[symptoma.com] Increased levels of parathyroid hormone further aggravate phosphorus loss.[consultant360.com] In infants and children, the signs and symptoms include: Abnormal "waddling" walk due to knock-knees (genu valgum) or bowed legs (genu varum) Thick wrists Ribs of the chest[dovemed.com]

    Missing: Some Patients May Be Clinically Asymptomatic
  • Primary Hyperparathyroidism

    It is imperative to consider that some patients, such as our patient described in this report, may be previously asymptomatic clinically and on the basis of laboratory findings[ncbi.nlm.nih.gov] When released, parathyroid hormone increases the release of calcium from the bone, reabsorption from the kidney, and secondarily stimulates absorption of calcium from the[en.wikibooks.org] On examination she had bilateral genu valgum.[ncbi.nlm.nih.gov]

  • Renal Osteodystrophy

    In advanced stages, blood tests will indicate decreased calcium and calcitriol (vitamin D) and increased phosphate, and parathyroid hormone levels.[en.wikipedia.org] , increased alkaline phosphatase, increased parathyroid hormone 3 Increased calcium, normal serum phosphate, increased alkaline phosphatase, normal parathyroid hormone 4 Decreased[orthobullets.com] In rats with chronic renal disease the plasma urea, phosphate and parathyroid hormone levels were significantly increased compared to rats with a uninephroctomy and none of[ncbi.nlm.nih.gov]

    Missing: Some Patients May Be Clinically Asymptomatic
  • Osteomalacia

    Bowing of the legs (genu varum) is typical, but knock knees (genu valgum) can also occur.[patient.info] The absence of short stature and lower limb deformities in some of these patients suggest a not so intense hypophosphatemia during infancy and childhood (53).[scielo.br] […] glands react to low calcium levels by secreting parathyroid hormone, which increases bone resorption to safeguard enough calcium in the blood.[aclr.com.es]

  • Rickets

    In the later course, levels are, slightly low because parathyroid hormone increases renal excretion. Very high or very low concentrations suggest renal rickets.[boneandspine.com] Abstract A 16-year-old boy with widening of the large joints of the extremities and bilateral genu valgum had been extensively treated with oral vitamin D, with little clinical[ncbi.nlm.nih.gov] Rickets was diagnosed in a 12-year-old girl presenting with short stature, genu valgum, eversion deformity at the ankle joints, and flat feet.[ncbi.nlm.nih.gov]

    Missing: Some Patients May Be Clinically Asymptomatic
  • X-Linked Hypophosphatemia

    Biochemical findings include elevated circulating levels of FGF-23 associated with hypophosphatemia, hyperphosphaturia, normal serum levels of calcium and parathyroid hormone[orpha.net] The author present 3 cases of medically treated x-linked hypophosphatemic rickets presenting with atypical genu valgum (knock knees).[austinpublishinggroup.com] Seventeen individuals had genu varum, 1 had genu valgum, and 4 had straight legs, attributable to successful osteotomies in 2.[ncbi.nlm.nih.gov]

    Missing: Some Patients May Be Clinically Asymptomatic
  • Parathyroid Adenoma

    She was found to have genu valgum at the knee joint, pectus carniatum, scoliosis and cystic changes in pelvis and calvarium.[ncbi.nlm.nih.gov] Laboratory tests will usually show increased calcium and parathyroid hormone levels.[symptoma.com] A parathyroid tumor is a growth inside a parathyroid gland which may cause increased levels of parathyroid hormones secreted by the parathyroid glands.[larianmd.com]

    Missing: Some Patients May Be Clinically Asymptomatic
  • Pseudohypoparathyroidism

    Abstract A22 month old boy with grand-mal seizures and hypocalcemia, had an elevated serum concentration of parathyroid hormone, increased urinary excretion of cyclic AMP,[nejm.org] valgum, coxa vara, cubitus valgus); and anomalies of the hands and feet, particularly short metacarpal and metatarsal bones of the …[pedsinreview.aappublications.org] […] glands and increased blood levels of parathyroid hormone.[medical-dictionary.thefreedictionary.com]

    Missing: Some Patients May Be Clinically Asymptomatic
  • Hypophosphatemia

    The absence of short stature and lower limb deformities in some of these patients suggest a not so intense hypophosphatemia during infancy and childhood (53).[scielo.br] Biochemical findings include elevated circulating levels of FGF-23 associated with hypophosphatemia, hyperphosphaturia, normal serum levels of calcium and parathyroid hormone[orpha.net] In infants and children, the signs and symptoms include: Abnormal "waddling" walk due to knock-knees (genu valgum) or bowed legs (genu varum) Thick wrists Ribs of the chest[dovemed.com]

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