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351 Possible Causes for Giant Platelet

  • Autosomal Dominant Macrothrombocytopenia

    giant platelet disorders [Table 1].[] […] disorders characterized by a triad of giant platelets, thrombocytopenia, and characteristic Döhle body-like leukocyte inclusions.[] Abstract Macrothrombocytopenia with leukocyte inclusions is a rare autosomal dominant platelet disorder characterized by a triad of giant platelets, thrombocytopenia, and[]

  • Bernard-Soulier Syndrome

    Other inherited giant platelet disorders, eg grey platelet syndrome. Investigations FBC and film: platelet count is usually low but may be normal.[] It is characterized by, among other symptoms, the presence of giant platelets. Hence the disorder is also known as Giant Platelet syndrome.[] Giant platelets are seen on the blood film. Bleeding time is prolonged and may be longer than 20 minutes.[]

  • May-Hegglin Thrombocytopenia

    @article{Noris1998ThrombocytopeniaGP, title {Thrombocytopenia, giant platelets, and leukocyte inclusion bodies (May-Hegglin anomaly): clinical and laboratory findings.}, author[] PURPOSE: May-Hegglin anomaly is a rare hereditary condition characterized by the triad of thrombocytopenia, giant platelets, and inclusion bodies in leukocytes.[] Platelet studies in whole ... more Giant platelet disorders (GPD) refer to rare, usually inherited states characterized by abnormally large platelets, thrombocytopenia and[]

  • Severe Autosomal Recessive Macrothrombocytopenia

    Giant platelet disorders are rare disorders featuring abnormally large platelets, thrombocytopenia and a tendency to bleeding.[] Autosomal dominant macrothrombocytopenia characterized by thrombocytopenia, giant platelets and leukocyte inclusions that are small and poorly organized.[] We suggest that p.V528M is neither associated with BPNH nor with thrombocytopenia and giant platelets, and represents a functional polymorphism.[]

  • Inherited Platelet Disorder

    The differential diagnosis includes the other inherited giant platelet disorders, as well as von Willebrand disease and immune thrombocytopenia purpura.[] Giant platelet disorders are rare disorders featuring abnormally large platelets, thrombocytopenia and a tendency to bleeding.[] […] life span Dense body defect Drug induced platelet dysfunction Exhausted platelets Giant platelet syndrome Glanzmann's thrombasthenia Glycoprotein Ia defect Glycoprotein Ib[]

  • Platelet Storage Pool Deficiency

    Abstract Jacobsen syndrome and Paris-Trousseau Syndrome share similar congenital anomalies, thrombocytopenia, giant platelet alpha granules resulting from fusion of smaller[] We evaluated two patients with Jacobsen syndrome who were thrombocytopenic and observed giant alpha granules in 15% of their platelets (BLOOD 94:81b, 1999).[] In some cases, they are associated with thrombocytopenias, giant platelets, and various comorbidities.[]

  • Thrombocytopenia

    Patients with MYH9-RD have giant platelets and leukocyte inclusion bodies caused by mutations in the MYH9 gene encoding the non-muscle myosin heavy chain II-A.[] May-Hegglin anomaly: thrombocytopenia, giant platelets and leukocyte inclusions (Döhle leukocyte inclusions).[]

  • Hereditary Nephritis

    A fourth kindred displaying the triad of hereditary nephritis, deafness and thrombocytopenia with giant platelets is described.[] Abstract A 14-year-old boy with persistent proteinuria (1.6-4.0 g/day), microscopic haematuria, moderate hypertension, macrothrombocytopenia (giant platelets, platelet number[] Thrombocytopenia with giant platelets was observed in peripheral blood smears.[]

  • Benign Migratory Glossitis

    Giant platelet disorders in African-American children misdiagnosed as idiopathic thrombocytopenic purpura. J Pediatr Hematol Oncol 1999;21:231-6. 50.[] Inherited abnormalities of platelets. Thromb Haemost 1999;82:468-80. 49. Young G, Luban N, White JG.[]

  • Gray Platelet Syndrome

    A 14-year-old boy had bleeding diathesis, mild thrombocytopenia, giant platelets with severe defect of alpha-granule secretory proteins, myelofibrosis and splenomegaly.[] Esa Jantunen, Inherited giant platelet disorders, European Journal of Haematology, 53, 4, (191-196), (2009).[] This patient was initially classified as a sporadic case of GPS, as electron microscopy failed to identify giant platelets and/or alpha-granule deficiency in his relatives[]

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