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197 Possible Causes for Gilbert's Disease, Gynecomastia, Pruritus

  • Liver Cirrhosis

    Isolated elevation of unconjugated bilirubin level Consider Gilbert syndrome or hemolysis.[aafp.org] Cirrhosis signs, include jaundice, gynecomastia (up to one third of men), loss of axillary and pubic hair, ascites, and splenomegaly (due to portal hypertension), finger clubbing[symptoma.com] Severe pruritus may require treatment with ultraviolet light or plasmapheresis.[patient.info]

  • Hyperthyroidism

    Arthritis Rheum. 2007; 56 2715-2718 24 El Fassi D, Banga JP, Gilbert JA. et al.[oadoi.org] […] palpitations and abnormal heart rhythms (the notable ones being atrial fibrillation), shortness of breath (dyspnea), loss of libido, amenorrhea, nausea, vomiting, diarrhea, gynecomastia[en.wikipedia.org] In conclusion, the diagnosis of hyperthyroidism may be delayed in patients in whom the primary manifestations were pruritus and jaundice.[ncbi.nlm.nih.gov]

  • Alcoholic Liver Disease

    Wilson's disease may lead to cirrhosis and liver failure. Gilbert's disease. In Gilbert's disease, there is an abnormality in bilirubin metabolism in the liver.[medicinenet.com] […] gain malnutrition and wasting anorexia fatigue confusion pruritus fever nausea and vomiting finger clubbing Dupuytren contracture leg swelling parotid gland enlargement gynecomastia[online.epocrates.com] In men, chronic alcoholism causes signs of hypogonadism and feminization (eg, smooth skin, lack of male-pattern baldness, gynecomastia, testicular atrophy, changes in pubic[merckmanuals.com]

  • Graves Disease

    A 40-year-old man with reactive arthritis, Graves' disease, type 2 diabetes mellitus, mitral valve prolapse, and Gilbert's disease presented with a one month history of jaundice[casesjournal.biomedcentral.com] Lack of sleep Lack of concentration and inability to focus Women may have less menstrual bleeding or may have no periods at all Men may suffer from erectile dysfunction, gynecomastia[news-medical.net] A 39-year-old multigravida woman presented 3 weeks postpartum with worsening generalised pruritus without primary rash.[ncbi.nlm.nih.gov]

  • Paraneoplastic Syndrome

    Joly P, Thomine E, Gilbert D, et al. Overlapping distribution of autoantibody specificities in paraneoplastic pemphigus and pemphigus vulgaris.[doi.org] World J Urol 17:22 PubMed CrossRef Google Scholar Haas GP, Pittaluga S, Gomella L et al (1989) Clinically occult Leydig cell tumor presenting with gynecomastia.[link.springer.com] This 59-year-old man developed ophthalmoplegia, dysarthria, dysphagia, pruritus, ataxia, corticobulbar and corticospinal signs in association with prostate cancer.[ncbi.nlm.nih.gov]

  • Hepatitis C

    Bush, Recent Epidemiological Changes in Infectious Diseases, Comprehensive Medicinal Chemistry III, 10.1016/B978-0-12-409547-2.12405-9, (511-552), (2017).[doi.org] As cirrhosis develops, symptoms and signs increase and may include: Elevated liver enzymes in the blood Weakness Loss of appetite Weight loss Breast enlargement in men ( gynecomastia[medicinenet.com] These neuropeptides may mediate the cutaneous neurogenic inflammation and pruritus in prurigo nodularis.[dx.doi.org]

  • Jaundice

    In Gilbert's disease there is an increase in levels of unconjugated bilirubin.[gpnotebook.co.uk] Men are checked for testicular atrophy and gynecomastia. Neurologic examination includes mental status assessment and evaluation for asterixis.[msdmanuals.com] […] encephalopathy by testing for asterixis and mental status changes; evaluation of signs of chronic liver disease to include bruising, spider angiomas, palmar erythema, and gynecomastia[aafp.org]

  • Acne Vulgaris

    Gulcan Saylam Kurtipek, Nıhal Sarı and Fatma Tuncez Akyurek, Significant reduction in bilirubin levels in a patient with Gilbert's Syndrome under isotretinoin treatment for[doi.org] […] libido Hyperkalemia Headache Breast tenderness Menstrual irregularities Fluid retention Liver dysfunction Blood clotting disorders Hematological disorders Muscle cramps Gynecomastia[ncbi.nlm.nih.gov] , stinging Cream, gel (0.05%, 0.1%) NA ( 240) Tretinoin (Retin-A) C Local erythema, peeling, dryness, pruritus, stinging Cream (0.025%, 0.05%, 0.1%) 27 ( 130) Gel (0.01%,[aafp.org]

  • Hemochromatosis

    Gilbert's syndrome and hereditary hemochromatosis predominantly affect Caucasians with a low incidence in Asians.[ncbi.nlm.nih.gov] Men: Impotence, loss of libido, gynecomastia, testicular atrophy. Women: Amenorrhea and loss of libido.[pathwaymedicine.org] This reference provides food for thought for dermatologists with prurigo or generalized pruritus patients.[clinicaladvisor.com]

  • Liver Disease

    disease Gilbert-Lereboullet syndrome Gilbert's disease Gilbert's syndrome hyperbilirubinemia 1 Meulengracht syndrome unconjugated benign bilirubinemia Bosma PJ, Chowdhury[ghr.nlm.nih.gov] […] a star of David) Drowsiness and confusion Parotid gland enlargement Spider angiomas Icterus Bilateral parotid swelling ( Credit ) Diminished axillary hair Spider angioma Gynecomastia[stanfordmedicine25.stanford.edu] This is a case of severe hypercholesterolemia and liver disease in a 3- year old male that presented with pruritus, pale stool, scleral ictus, and abdominal distention.[ncbi.nlm.nih.gov]

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